Synthesis and DNA-binding studies of two ruthenium(II) complexes of an intercalating ligand
Two new ruthenium(II) complexes [Ru(bpy) 2(HBT)] 2+ ( 1) and [Ru(phen) 2(HBT)] 2+ ( 2) (bpy = 2,2′-bipyridine; phen = 1,10-phenanthroline; HBT = 11 H, 13 H-4, 5,9,10,12,14-hexaaza-benzo [ b] triphenylene) have been synthesized and characterized by elemental analysis, mass spectra, 1H NMR and cyclic...
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| Veröffentlicht in: | European journal of medicinal chemistry 2009-05, Vol.44 (5), p.2044-2051 |
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| container_title | European journal of medicinal chemistry |
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| creator | Lawrence Arockiasamy, D. Radhika, S. Parthasarathi, R. Nair, Balachandran Unni |
| description | Two new ruthenium(II) complexes [Ru(bpy)
2(HBT)]
2+ (
1) and [Ru(phen)
2(HBT)]
2+ (
2) (bpy
=
2,2′-bipyridine; phen
=
1,10-phenanthroline; HBT
=
11
H, 13
H-4, 5,9,10,12,14-hexaaza-benzo [
b] triphenylene) have been synthesized and characterized by elemental analysis, mass spectra,
1H NMR and cyclic voltammetry. The DNA binding property of the two complexes has been investigated employing absorption spectroscopy, fluorescence spectroscopy and viscosity measurements. Both complexes
1 and
2 have been found to prefer intercalative binding to DNA. The DNA binding constants for the two complexes have been measured to be 5.71
±
0.20
×
10
7 and 4.65
±
0.20
×
10
7
M
−1 through ethidium bromide displacement method. Molecular modeling studies too indicate that both complexes
1 and
2 prefer intercalative binding to DNA and both these complexes exhibit similar DNA binding energies. Both complexes
1 and
2 bring about photocleavage of plasmid DNA when irradiated at 440
nm.
▪ |
| doi_str_mv | 10.1016/j.ejmech.2008.10.013 |
| format | Article |
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2(HBT)]
2+ (
1) and [Ru(phen)
2(HBT)]
2+ (
2) (bpy
=
2,2′-bipyridine; phen
=
1,10-phenanthroline; HBT
=
11
H, 13
H-4, 5,9,10,12,14-hexaaza-benzo [
b] triphenylene) have been synthesized and characterized by elemental analysis, mass spectra,
1H NMR and cyclic voltammetry. The DNA binding property of the two complexes has been investigated employing absorption spectroscopy, fluorescence spectroscopy and viscosity measurements. Both complexes
1 and
2 have been found to prefer intercalative binding to DNA. The DNA binding constants for the two complexes have been measured to be 5.71
±
0.20
×
10
7 and 4.65
±
0.20
×
10
7
M
−1 through ethidium bromide displacement method. Molecular modeling studies too indicate that both complexes
1 and
2 prefer intercalative binding to DNA and both these complexes exhibit similar DNA binding energies. Both complexes
1 and
2 bring about photocleavage of plasmid DNA when irradiated at 440
nm.
▪</description><identifier>ISSN: 0223-5234</identifier><identifier>EISSN: 1768-3254</identifier><identifier>DOI: 10.1016/j.ejmech.2008.10.013</identifier><identifier>PMID: 19026470</identifier><identifier>CODEN: EJMCA5</identifier><language>eng</language><publisher>Kidlington: Elsevier Masson SAS</publisher><subject>2,2'-Dipyridyl ; Antineoplastic agents ; Binding Sites ; Biological and medical sciences ; DNA ; DNA - chemistry ; DNA - metabolism ; DNA - radiation effects ; Ethidium bromide ; General aspects ; Intercalating Agents - chemistry ; Ligands ; Medical sciences ; Pharmacology. Drug treatments ; Phenanthrolines ; Photocleavage ; Photolysis ; Plasmids - radiation effects ; Polypyridyl ; Ruthenium ; Ruthenium(II) complexes</subject><ispartof>European journal of medicinal chemistry, 2009-05, Vol.44 (5), p.2044-2051</ispartof><rights>2008 Elsevier Masson SAS</rights><rights>2009 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c390t-489793bafe3dc84f677433d3501049115a64d08f6caea561099c9b048dd10c9c3</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.ejmech.2008.10.013$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3550,27924,27925,45995</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=21398877$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/19026470$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Lawrence Arockiasamy, D.</creatorcontrib><creatorcontrib>Radhika, S.</creatorcontrib><creatorcontrib>Parthasarathi, R.</creatorcontrib><creatorcontrib>Nair, Balachandran Unni</creatorcontrib><title>Synthesis and DNA-binding studies of two ruthenium(II) complexes of an intercalating ligand</title><title>European journal of medicinal chemistry</title><addtitle>Eur J Med Chem</addtitle><description>Two new ruthenium(II) complexes [Ru(bpy)
2(HBT)]
2+ (
1) and [Ru(phen)
2(HBT)]
2+ (
2) (bpy
=
2,2′-bipyridine; phen
=
1,10-phenanthroline; HBT
=
11
H, 13
H-4, 5,9,10,12,14-hexaaza-benzo [
b] triphenylene) have been synthesized and characterized by elemental analysis, mass spectra,
1H NMR and cyclic voltammetry. The DNA binding property of the two complexes has been investigated employing absorption spectroscopy, fluorescence spectroscopy and viscosity measurements. Both complexes
1 and
2 have been found to prefer intercalative binding to DNA. The DNA binding constants for the two complexes have been measured to be 5.71
±
0.20
×
10
7 and 4.65
±
0.20
×
10
7
M
−1 through ethidium bromide displacement method. Molecular modeling studies too indicate that both complexes
1 and
2 prefer intercalative binding to DNA and both these complexes exhibit similar DNA binding energies. Both complexes
1 and
2 bring about photocleavage of plasmid DNA when irradiated at 440
nm.
▪</description><subject>2,2'-Dipyridyl</subject><subject>Antineoplastic agents</subject><subject>Binding Sites</subject><subject>Biological and medical sciences</subject><subject>DNA</subject><subject>DNA - chemistry</subject><subject>DNA - metabolism</subject><subject>DNA - radiation effects</subject><subject>Ethidium bromide</subject><subject>General aspects</subject><subject>Intercalating Agents - chemistry</subject><subject>Ligands</subject><subject>Medical sciences</subject><subject>Pharmacology. Drug treatments</subject><subject>Phenanthrolines</subject><subject>Photocleavage</subject><subject>Photolysis</subject><subject>Plasmids - radiation effects</subject><subject>Polypyridyl</subject><subject>Ruthenium</subject><subject>Ruthenium(II) complexes</subject><issn>0223-5234</issn><issn>1768-3254</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2009</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kMFu1DAQhq0K1G5L36CqcgHBIdtx7Dj2BakqBVaq6AE49WB57UnrVeIsdgL07XGUFdw4WRp__z-jj5ALCmsKVFzt1rjr0T6tKwCZR2ug7IisaCNkyaqavyArqCpW1hXjJ-Q0pR0A1ALgmJxQBZXgDazIw9fnMD5h8qkwwRUfvlyXWx-cD49FGifnMRVDW4y_hiJOmQt-6t9uNu8KO_T7Dn8v3yYUPowYrenMOEc7_5jbXpGXrekSnh_eM_L94-23m8_l3f2nzc31XWmZgrHkUjWKbU2LzFnJW9E0nDHHaqDAFaW1EdyBbIU1aGpBQSmrtsClcxSssuyMvFl693H4MWEade-Txa4zAYcpadGAFDVrMsgX0MYhpYit3kffm_isKehZqt7pRaqepc7TLDXHLg_907ZH9y90sJiB1wfApOygjSZYn_5yFWVKymbe_37hMNv46THqZD0Gi85HtKN2g___JX8A72WWMw</recordid><startdate>20090501</startdate><enddate>20090501</enddate><creator>Lawrence Arockiasamy, D.</creator><creator>Radhika, S.</creator><creator>Parthasarathi, R.</creator><creator>Nair, Balachandran Unni</creator><general>Elsevier Masson SAS</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20090501</creationdate><title>Synthesis and DNA-binding studies of two ruthenium(II) complexes of an intercalating ligand</title><author>Lawrence Arockiasamy, D. ; Radhika, S. ; Parthasarathi, R. ; Nair, Balachandran Unni</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c390t-489793bafe3dc84f677433d3501049115a64d08f6caea561099c9b048dd10c9c3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2009</creationdate><topic>2,2'-Dipyridyl</topic><topic>Antineoplastic agents</topic><topic>Binding Sites</topic><topic>Biological and medical sciences</topic><topic>DNA</topic><topic>DNA - chemistry</topic><topic>DNA - metabolism</topic><topic>DNA - radiation effects</topic><topic>Ethidium bromide</topic><topic>General aspects</topic><topic>Intercalating Agents - chemistry</topic><topic>Ligands</topic><topic>Medical sciences</topic><topic>Pharmacology. Drug treatments</topic><topic>Phenanthrolines</topic><topic>Photocleavage</topic><topic>Photolysis</topic><topic>Plasmids - radiation effects</topic><topic>Polypyridyl</topic><topic>Ruthenium</topic><topic>Ruthenium(II) complexes</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Lawrence Arockiasamy, D.</creatorcontrib><creatorcontrib>Radhika, S.</creatorcontrib><creatorcontrib>Parthasarathi, R.</creatorcontrib><creatorcontrib>Nair, Balachandran Unni</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>European journal of medicinal chemistry</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Lawrence Arockiasamy, D.</au><au>Radhika, S.</au><au>Parthasarathi, R.</au><au>Nair, Balachandran Unni</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Synthesis and DNA-binding studies of two ruthenium(II) complexes of an intercalating ligand</atitle><jtitle>European journal of medicinal chemistry</jtitle><addtitle>Eur J Med Chem</addtitle><date>2009-05-01</date><risdate>2009</risdate><volume>44</volume><issue>5</issue><spage>2044</spage><epage>2051</epage><pages>2044-2051</pages><issn>0223-5234</issn><eissn>1768-3254</eissn><coden>EJMCA5</coden><abstract>Two new ruthenium(II) complexes [Ru(bpy)
2(HBT)]
2+ (
1) and [Ru(phen)
2(HBT)]
2+ (
2) (bpy
=
2,2′-bipyridine; phen
=
1,10-phenanthroline; HBT
=
11
H, 13
H-4, 5,9,10,12,14-hexaaza-benzo [
b] triphenylene) have been synthesized and characterized by elemental analysis, mass spectra,
1H NMR and cyclic voltammetry. The DNA binding property of the two complexes has been investigated employing absorption spectroscopy, fluorescence spectroscopy and viscosity measurements. Both complexes
1 and
2 have been found to prefer intercalative binding to DNA. The DNA binding constants for the two complexes have been measured to be 5.71
±
0.20
×
10
7 and 4.65
±
0.20
×
10
7
M
−1 through ethidium bromide displacement method. Molecular modeling studies too indicate that both complexes
1 and
2 prefer intercalative binding to DNA and both these complexes exhibit similar DNA binding energies. Both complexes
1 and
2 bring about photocleavage of plasmid DNA when irradiated at 440
nm.
▪</abstract><cop>Kidlington</cop><pub>Elsevier Masson SAS</pub><pmid>19026470</pmid><doi>10.1016/j.ejmech.2008.10.013</doi><tpages>8</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0223-5234 |
| ispartof | European journal of medicinal chemistry, 2009-05, Vol.44 (5), p.2044-2051 |
| issn | 0223-5234 1768-3254 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_67086537 |
| source | MEDLINE; Access via ScienceDirect (Elsevier) |
| subjects | 2,2'-Dipyridyl Antineoplastic agents Binding Sites Biological and medical sciences DNA DNA - chemistry DNA - metabolism DNA - radiation effects Ethidium bromide General aspects Intercalating Agents - chemistry Ligands Medical sciences Pharmacology. Drug treatments Phenanthrolines Photocleavage Photolysis Plasmids - radiation effects Polypyridyl Ruthenium Ruthenium(II) complexes |
| title | Synthesis and DNA-binding studies of two ruthenium(II) complexes of an intercalating ligand |
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