Involvement of SR Proteins in mRNA Surveillance

Nonsense mutations influence several aspects of gene expression, including mRNA stability and splicing fidelity, but the mechanism by which premature termination codons (PTCs) can apparently affect splice-site selection remains elusive. We used a model human β-globin gene with duplicated 5′ splice s...

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Veröffentlicht in:	Molecular cell 2004-11, Vol.16 (4), p.597-607
Hauptverfasser:	Zhang, Zuo, Krainer, Adrian R.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Blotting, Western Cercopithecus aethiops Codon, Nonsense Codon, Terminator COS Cells Exons Gene Expression Regulation Globins - genetics HeLa Cells Humans Introns Nuclear Proteins - genetics Nuclear Proteins - metabolism Point Mutation RNA Interference RNA Precursors - metabolism RNA Splicing RNA Stability RNA, Messenger - genetics RNA, Messenger - metabolism RNA-Binding Proteins Serine-Arginine Splicing Factors
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