P-Cadherin is up-regulated by the antiestrogen ICI 182,780 and promotes invasion of human breast cancer cells
P-cadherin expression in breast carcinomas has been associated with tumors of high histologic grade and lacking estrogen receptor-alpha, suggesting a link between these proteins. In the MCF-7/AZ breast cancer cell line, blocking estrogen receptor-alpha signaling with the antiestrogen ICI 182,780 ind...
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| Veröffentlicht in: | Cancer research (Chicago, Ill.) Ill.), 2004-11, Vol.64 (22), p.8309-8317 |
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| container_title | Cancer research (Chicago, Ill.) |
| container_volume | 64 |
| creator | PAREDES, Joana STOVE, Christophe STOVE, Veronique MILANEZI, Fernanda VAN MARCK, Veerle DERYCKE, Lara MAREEL, Marc BRACKE, Marc SCHMITT, Fernando |
| description | P-cadherin expression in breast carcinomas has been associated with tumors of high histologic grade and lacking estrogen receptor-alpha, suggesting a link between these proteins. In the MCF-7/AZ breast cancer cell line, blocking estrogen receptor-alpha signaling with the antiestrogen ICI 182,780 induced an increase of P-cadherin, which coincided with induction of in vitro invasion. Retroviral transduction of MCF-7/AZ cells, as well as HEK 293T cells, showed the proinvasive activity of P-cadherin, which requires the juxtamembrane domain of its cytoplasmic tail. This study establishes a direct link between P-cadherin expression and the lack of estrogen receptor-alpha signaling in breast cancer cells and suggests a role for P-cadherin in invasion, through its interaction with proteins bound to the juxtamembrane domain. |
| doi_str_mv | 10.1158/0008-5472.can-04-0795 |
| format | Article |
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In the MCF-7/AZ breast cancer cell line, blocking estrogen receptor-alpha signaling with the antiestrogen ICI 182,780 induced an increase of P-cadherin, which coincided with induction of in vitro invasion. Retroviral transduction of MCF-7/AZ cells, as well as HEK 293T cells, showed the proinvasive activity of P-cadherin, which requires the juxtamembrane domain of its cytoplasmic tail. 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Andrology. Obstetrics ; Humans ; Mammary gland diseases ; Medical sciences ; Neoplasm Invasiveness ; Pharmacology. 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In the MCF-7/AZ breast cancer cell line, blocking estrogen receptor-alpha signaling with the antiestrogen ICI 182,780 induced an increase of P-cadherin, which coincided with induction of in vitro invasion. Retroviral transduction of MCF-7/AZ cells, as well as HEK 293T cells, showed the proinvasive activity of P-cadherin, which requires the juxtamembrane domain of its cytoplasmic tail. This study establishes a direct link between P-cadherin expression and the lack of estrogen receptor-alpha signaling in breast cancer cells and suggests a role for P-cadherin in invasion, through its interaction with proteins bound to the juxtamembrane domain.</description><subject>Antineoplastic agents</subject><subject>Base Sequence</subject><subject>Biological and medical sciences</subject><subject>Breast Neoplasms - metabolism</subject><subject>Breast Neoplasms - pathology</subject><subject>Cadherins - metabolism</subject><subject>Cell Adhesion - drug effects</subject><subject>DNA Primers</subject><subject>DNA, Complementary</subject><subject>Estradiol - analogs & derivatives</subject><subject>Estradiol - pharmacology</subject><subject>Estrogen Receptor alpha - metabolism</subject><subject>Estrogen Receptor Modulators - pharmacology</subject><subject>Gynecology. Andrology. Obstetrics</subject><subject>Humans</subject><subject>Mammary gland diseases</subject><subject>Medical sciences</subject><subject>Neoplasm Invasiveness</subject><subject>Pharmacology. Drug treatments</subject><subject>Reverse Transcriptase Polymerase Chain Reaction</subject><subject>Tumors</subject><subject>Up-Regulation - drug effects</subject><issn>0008-5472</issn><issn>1538-7445</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2004</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkctuFDEQRS0EIpPAJ4C8gRUOdvu9jFpARoqABaytGrs606gfg92NlL_HrYzIklWpVKeqru4l5I3g10Jo95Fz7phWtrmOMDGuGLdePyM7oaVjVin9nOz-MRfkspRftdWC65fkQmitnPF-R8bvrIV0xNxPtC90PbGM9-sACyZ6eKDLESlMS49lyfM9TnTf7qlwzQfreB0kesrzOC9YaD_9gdLPE507elxHmOghI5SFVnkRM404DOUVedHBUPD1uV6Rn58__Whv2d23L_v25o5FLeTCAIRxSSUXpUENSqVoOBcWhTo0pgGU2ibpO5WMh85zixG8TNZjlI0EKa_I-8e7Vd7vtYoPY182BTDhvJZgLHfKG_FfUFjJVeUqqB_BmOdSMnbhlPsR8kMQPGyBhM3ssJkd2puvgauwBVL33p4frIcR09PWOYEKvDsDUCIMXa529eWJM40Vygv5Fwwiku8</recordid><startdate>20041115</startdate><enddate>20041115</enddate><creator>PAREDES, Joana</creator><creator>STOVE, Christophe</creator><creator>STOVE, Veronique</creator><creator>MILANEZI, Fernanda</creator><creator>VAN MARCK, Veerle</creator><creator>DERYCKE, Lara</creator><creator>MAREEL, Marc</creator><creator>BRACKE, Marc</creator><creator>SCHMITT, Fernando</creator><general>American Association for Cancer Research</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TO</scope><scope>H94</scope><scope>7X8</scope></search><sort><creationdate>20041115</creationdate><title>P-Cadherin is up-regulated by the antiestrogen ICI 182,780 and promotes invasion of human breast cancer cells</title><author>PAREDES, Joana ; STOVE, Christophe ; STOVE, Veronique ; MILANEZI, Fernanda ; VAN MARCK, Veerle ; DERYCKE, Lara ; MAREEL, Marc ; BRACKE, Marc ; SCHMITT, Fernando</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c513t-aa168d4d8c36e5a44dc60017e14b262ae357d39f4d69af907eca93d79ec323a33</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2004</creationdate><topic>Antineoplastic agents</topic><topic>Base Sequence</topic><topic>Biological and medical sciences</topic><topic>Breast Neoplasms - metabolism</topic><topic>Breast Neoplasms - pathology</topic><topic>Cadherins - metabolism</topic><topic>Cell Adhesion - drug effects</topic><topic>DNA Primers</topic><topic>DNA, Complementary</topic><topic>Estradiol - analogs & derivatives</topic><topic>Estradiol - pharmacology</topic><topic>Estrogen Receptor alpha - metabolism</topic><topic>Estrogen Receptor Modulators - pharmacology</topic><topic>Gynecology. Andrology. Obstetrics</topic><topic>Humans</topic><topic>Mammary gland diseases</topic><topic>Medical sciences</topic><topic>Neoplasm Invasiveness</topic><topic>Pharmacology. 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In the MCF-7/AZ breast cancer cell line, blocking estrogen receptor-alpha signaling with the antiestrogen ICI 182,780 induced an increase of P-cadherin, which coincided with induction of in vitro invasion. Retroviral transduction of MCF-7/AZ cells, as well as HEK 293T cells, showed the proinvasive activity of P-cadherin, which requires the juxtamembrane domain of its cytoplasmic tail. This study establishes a direct link between P-cadherin expression and the lack of estrogen receptor-alpha signaling in breast cancer cells and suggests a role for P-cadherin in invasion, through its interaction with proteins bound to the juxtamembrane domain.</abstract><cop>Philadelphia, PA</cop><pub>American Association for Cancer Research</pub><pmid>15548699</pmid><doi>10.1158/0008-5472.can-04-0795</doi><tpages>9</tpages><oa>free_for_read</oa></addata></record> |
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| source | MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; American Association for Cancer Research |
| subjects | Antineoplastic agents Base Sequence Biological and medical sciences Breast Neoplasms - metabolism Breast Neoplasms - pathology Cadherins - metabolism Cell Adhesion - drug effects DNA Primers DNA, Complementary Estradiol - analogs & derivatives Estradiol - pharmacology Estrogen Receptor alpha - metabolism Estrogen Receptor Modulators - pharmacology Gynecology. Andrology. Obstetrics Humans Mammary gland diseases Medical sciences Neoplasm Invasiveness Pharmacology. Drug treatments Reverse Transcriptase Polymerase Chain Reaction Tumors Up-Regulation - drug effects |
| title | P-Cadherin is up-regulated by the antiestrogen ICI 182,780 and promotes invasion of human breast cancer cells |
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