Computational modeling and surface plasmon resonance analyses in the assessment of peptide ligands interacting with fibrin γ(312–324) epitope

Fibrin represents a suitable target for addressing delivery systems loaded by fibrinolytic drugs. Selective ligands capable to recognize fibrin could be used as targeting moieties for such systems. In this study the interactions between the γ(312–324) epitope of human fibrin and peptidic ligands wer...

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Veröffentlicht in:	European journal of medicinal chemistry 2009-05, Vol.44 (5), p.2128-2134
Hauptverfasser:	Massarelli, Ilaria, Bianucci, Anna M., Chiellini, Federica, Eidelman, Chaim, Chiellini, Emo
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Computer Simulation Epitopes Fibrin Fibrin - metabolism GBSA Humans Ligands Peptides - metabolism Protein Binding Solvents SPR (surface plasmon resonance) Surface Plasmon Resonance Thermodynamics
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