Mechanistic population pharmacokinetics of total and unbound paclitaxel for a new nanodroplet formulation versus Taxol in cancer patients

Purpose Our objectives were (1) to compare the disposition and in vivo release of paclitaxel between a tocopherol-based Cremophor-free formulation (Tocosol Paclitaxel ® ) and Cremophor ® EL-formulated paclitaxel (Taxol ® ) in human subjects, and (2) to develop a mechanistic model for unbound and tot...

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