Blood lymphocyte chimerism associated with IVF and monochorionic dizygous twinning: Case report
We report on dizygotic (DZ) twins, conceived by IVF and ICSI with assisted hatching, who each had a mixture of 46,XX and 46,XY cells in blood lymphocytes. The female twin had mild genitalia abnormalities but further study revealed anatomically normal reproductive anatomy. Chromosome and fluorescence...
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| Veröffentlicht in: | Human reproduction (Oxford) 2004-12, Vol.19 (12), p.2816-2821 |
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| creator | Williams, C.A. Wallace, M.R. Drury, K.C. Kipersztok, S. Edwards, R.K. Williams, R.S. Haller, M.J. Schatz, D.A. Silverstein, J.H. Gray, B.A. Zori, R.T. |
| description | We report on dizygotic (DZ) twins, conceived by IVF and ICSI with assisted hatching, who each had a mixture of 46,XX and 46,XY cells in blood lymphocytes. The female twin had mild genitalia abnormalities but further study revealed anatomically normal reproductive anatomy. Chromosome and fluorescence in situ hybridization studies of buccal, skin and ovarian tissue were normal, as were buccal tissue DNA studies. Fetal ultrasound and fetal membrane pathology were consistent with a monochorionic, diamniotic placenta (MCDAP). These twins thus have blood chimerism but are not chimeric in the other tissues studied. The mechanism for the chimerism could be due to either placental vascular anastamoses (after the development of the haematoblast stem cells) or due to an admixture of trophoblast cells during early blastocyst development. Such trophoblast cell admixtures would be restricted to the extraembryonic tissues so that general physical development in the fetus is normal and without somatic cell chimerism. This case in combination with others previously reported suggests that in IVF conceptions, the prevalence of blood chimerism associated with twinning, and the occurrence of DZ twinning associated with MCDAP, may be higher than previously thought. |
| doi_str_mv | 10.1093/humrep/deh533 |
| format | Article |
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The female twin had mild genitalia abnormalities but further study revealed anatomically normal reproductive anatomy. Chromosome and fluorescence in situ hybridization studies of buccal, skin and ovarian tissue were normal, as were buccal tissue DNA studies. Fetal ultrasound and fetal membrane pathology were consistent with a monochorionic, diamniotic placenta (MCDAP). These twins thus have blood chimerism but are not chimeric in the other tissues studied. The mechanism for the chimerism could be due to either placental vascular anastamoses (after the development of the haematoblast stem cells) or due to an admixture of trophoblast cells during early blastocyst development. Such trophoblast cell admixtures would be restricted to the extraembryonic tissues so that general physical development in the fetus is normal and without somatic cell chimerism. This case in combination with others previously reported suggests that in IVF conceptions, the prevalence of blood chimerism associated with twinning, and the occurrence of DZ twinning associated with MCDAP, may be higher than previously thought.</description><identifier>ISSN: 0268-1161</identifier><identifier>EISSN: 1460-2350</identifier><identifier>DOI: 10.1093/humrep/deh533</identifier><identifier>PMID: 15375077</identifier><identifier>CODEN: HUREEE</identifier><language>eng</language><publisher>Oxford: Oxford University Press</publisher><subject>Adult ; assisted hatching ; assisted reproduction techniques ; Biological and medical sciences ; Birth control ; blood chimerism ; Chimera ; Chorion ; Diseases in Twins - genetics ; Endocrine System - metabolism ; Female ; Fertilization in Vitro ; Fibroblasts - physiology ; Genitalia - abnormalities ; Gynecology. Andrology. Obstetrics ; Humans ; In Situ Hybridization, Fluorescence ; Infant ; Infant, Newborn ; IVF ; Lymphocytes - physiology ; Male ; Medical sciences ; Microsatellite Repeats ; monochorionic placenta ; Mosaicism ; Ovary - abnormalities ; Pregnancy ; Skin - cytology ; Sterility. Assisted procreation ; Twins, Dizygotic - genetics ; Ultrasonography, Prenatal</subject><ispartof>Human reproduction (Oxford), 2004-12, Vol.19 (12), p.2816-2821</ispartof><rights>Human Reproduction vol. 19 no. 12 © European Society of Human Reproduction and Embryology 2004; all rights reserved 2004</rights><rights>2005 INIST-CNRS</rights><rights>Copyright Oxford University Press(England) Dec 2004</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c450t-a3b46a8f3be36b18f3e0fb9cf91486aa8bf70e9956d924724d478298f349e1f83</citedby><cites>FETCH-LOGICAL-c450t-a3b46a8f3be36b18f3e0fb9cf91486aa8bf70e9956d924724d478298f349e1f83</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,1578,27901,27902</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=16372765$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/15375077$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Williams, C.A.</creatorcontrib><creatorcontrib>Wallace, M.R.</creatorcontrib><creatorcontrib>Drury, K.C.</creatorcontrib><creatorcontrib>Kipersztok, S.</creatorcontrib><creatorcontrib>Edwards, R.K.</creatorcontrib><creatorcontrib>Williams, R.S.</creatorcontrib><creatorcontrib>Haller, M.J.</creatorcontrib><creatorcontrib>Schatz, D.A.</creatorcontrib><creatorcontrib>Silverstein, J.H.</creatorcontrib><creatorcontrib>Gray, B.A.</creatorcontrib><creatorcontrib>Zori, R.T.</creatorcontrib><title>Blood lymphocyte chimerism associated with IVF and monochorionic dizygous twinning: Case report</title><title>Human reproduction (Oxford)</title><addtitle>Hum. Reprod</addtitle><addtitle>Hum. Reprod</addtitle><description>We report on dizygotic (DZ) twins, conceived by IVF and ICSI with assisted hatching, who each had a mixture of 46,XX and 46,XY cells in blood lymphocytes. The female twin had mild genitalia abnormalities but further study revealed anatomically normal reproductive anatomy. Chromosome and fluorescence in situ hybridization studies of buccal, skin and ovarian tissue were normal, as were buccal tissue DNA studies. Fetal ultrasound and fetal membrane pathology were consistent with a monochorionic, diamniotic placenta (MCDAP). These twins thus have blood chimerism but are not chimeric in the other tissues studied. The mechanism for the chimerism could be due to either placental vascular anastamoses (after the development of the haematoblast stem cells) or due to an admixture of trophoblast cells during early blastocyst development. Such trophoblast cell admixtures would be restricted to the extraembryonic tissues so that general physical development in the fetus is normal and without somatic cell chimerism. This case in combination with others previously reported suggests that in IVF conceptions, the prevalence of blood chimerism associated with twinning, and the occurrence of DZ twinning associated with MCDAP, may be higher than previously thought.</description><subject>Adult</subject><subject>assisted hatching</subject><subject>assisted reproduction techniques</subject><subject>Biological and medical sciences</subject><subject>Birth control</subject><subject>blood chimerism</subject><subject>Chimera</subject><subject>Chorion</subject><subject>Diseases in Twins - genetics</subject><subject>Endocrine System - metabolism</subject><subject>Female</subject><subject>Fertilization in Vitro</subject><subject>Fibroblasts - physiology</subject><subject>Genitalia - abnormalities</subject><subject>Gynecology. Andrology. Obstetrics</subject><subject>Humans</subject><subject>In Situ Hybridization, Fluorescence</subject><subject>Infant</subject><subject>Infant, Newborn</subject><subject>IVF</subject><subject>Lymphocytes - physiology</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Microsatellite Repeats</subject><subject>monochorionic placenta</subject><subject>Mosaicism</subject><subject>Ovary - abnormalities</subject><subject>Pregnancy</subject><subject>Skin - cytology</subject><subject>Sterility. Assisted procreation</subject><subject>Twins, Dizygotic - genetics</subject><subject>Ultrasonography, Prenatal</subject><issn>0268-1161</issn><issn>1460-2350</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2004</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqF0T1v1TAUBmALgeilMLIiC6mIJa0dO_5ga69aWqmIgQ9VLJbjOI1LYgc7UXv59bhKRKUunXyGR-ccnxeAtxgdYiTJUTcP0Y5Hje0qQp6BDaYMFSWp0HOwQSUTBcYM74FXKd0glEvBXoI9XBFeIc43QJ30ITSw3w1jF8xustB0brDRpQHqlIJxerINvHVTBy9-nkHtGzgEH0wXogveGdi4v7vrMCc43Trvnb_-BLc6WZi3CnF6DV60uk_2zfrugx9np9-358Xl188X2-PLwtAKTYUmNWVatKS2hNU4Fxa1tTStxFQwrUXdcmSlrFgjS8pL2lAuSpkdlRa3guyDD0vfMYY_s02TGlwytu-1t3k5xTjKnqInYYm4kKK87_j-EbwJc_T5E6rEWFSYSplRsSATQ0rRtmqMbtBxpzBS9_moJR-15JP9u7XpXA-2edBrIBkcrEAno_s2am9cenCM8JKzKruPiwvz-OTMdUeXJnv3H-v4O18lj1XnV7_UCeIYf_l2pRj5B77Ft5U</recordid><startdate>20041201</startdate><enddate>20041201</enddate><creator>Williams, C.A.</creator><creator>Wallace, M.R.</creator><creator>Drury, K.C.</creator><creator>Kipersztok, S.</creator><creator>Edwards, R.K.</creator><creator>Williams, R.S.</creator><creator>Haller, M.J.</creator><creator>Schatz, D.A.</creator><creator>Silverstein, J.H.</creator><creator>Gray, B.A.</creator><creator>Zori, R.T.</creator><general>Oxford University Press</general><general>Oxford Publishing Limited (England)</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TM</scope><scope>8FD</scope><scope>FR3</scope><scope>K9.</scope><scope>P64</scope><scope>RC3</scope><scope>7T5</scope><scope>H94</scope><scope>7X8</scope></search><sort><creationdate>20041201</creationdate><title>Blood lymphocyte chimerism associated with IVF and monochorionic dizygous twinning: Case report</title><author>Williams, C.A. ; Wallace, M.R. ; Drury, K.C. ; Kipersztok, S. ; Edwards, R.K. ; Williams, R.S. ; Haller, M.J. ; Schatz, D.A. ; Silverstein, J.H. ; Gray, B.A. ; Zori, R.T.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c450t-a3b46a8f3be36b18f3e0fb9cf91486aa8bf70e9956d924724d478298f349e1f83</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2004</creationdate><topic>Adult</topic><topic>assisted hatching</topic><topic>assisted reproduction techniques</topic><topic>Biological and medical sciences</topic><topic>Birth control</topic><topic>blood chimerism</topic><topic>Chimera</topic><topic>Chorion</topic><topic>Diseases in Twins - genetics</topic><topic>Endocrine System - metabolism</topic><topic>Female</topic><topic>Fertilization in Vitro</topic><topic>Fibroblasts - physiology</topic><topic>Genitalia - abnormalities</topic><topic>Gynecology. Andrology. Obstetrics</topic><topic>Humans</topic><topic>In Situ Hybridization, Fluorescence</topic><topic>Infant</topic><topic>Infant, Newborn</topic><topic>IVF</topic><topic>Lymphocytes - physiology</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Microsatellite Repeats</topic><topic>monochorionic placenta</topic><topic>Mosaicism</topic><topic>Ovary - abnormalities</topic><topic>Pregnancy</topic><topic>Skin - cytology</topic><topic>Sterility. Assisted procreation</topic><topic>Twins, Dizygotic - genetics</topic><topic>Ultrasonography, Prenatal</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Williams, C.A.</creatorcontrib><creatorcontrib>Wallace, M.R.</creatorcontrib><creatorcontrib>Drury, K.C.</creatorcontrib><creatorcontrib>Kipersztok, S.</creatorcontrib><creatorcontrib>Edwards, R.K.</creatorcontrib><creatorcontrib>Williams, R.S.</creatorcontrib><creatorcontrib>Haller, M.J.</creatorcontrib><creatorcontrib>Schatz, D.A.</creatorcontrib><creatorcontrib>Silverstein, J.H.</creatorcontrib><creatorcontrib>Gray, B.A.</creatorcontrib><creatorcontrib>Zori, R.T.</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Nucleic Acids Abstracts</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Genetics Abstracts</collection><collection>Immunology Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Human reproduction (Oxford)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Williams, C.A.</au><au>Wallace, M.R.</au><au>Drury, K.C.</au><au>Kipersztok, S.</au><au>Edwards, R.K.</au><au>Williams, R.S.</au><au>Haller, M.J.</au><au>Schatz, D.A.</au><au>Silverstein, J.H.</au><au>Gray, B.A.</au><au>Zori, R.T.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Blood lymphocyte chimerism associated with IVF and monochorionic dizygous twinning: Case report</atitle><jtitle>Human reproduction (Oxford)</jtitle><stitle>Hum. Reprod</stitle><addtitle>Hum. Reprod</addtitle><date>2004-12-01</date><risdate>2004</risdate><volume>19</volume><issue>12</issue><spage>2816</spage><epage>2821</epage><pages>2816-2821</pages><issn>0268-1161</issn><eissn>1460-2350</eissn><coden>HUREEE</coden><abstract>We report on dizygotic (DZ) twins, conceived by IVF and ICSI with assisted hatching, who each had a mixture of 46,XX and 46,XY cells in blood lymphocytes. The female twin had mild genitalia abnormalities but further study revealed anatomically normal reproductive anatomy. Chromosome and fluorescence in situ hybridization studies of buccal, skin and ovarian tissue were normal, as were buccal tissue DNA studies. Fetal ultrasound and fetal membrane pathology were consistent with a monochorionic, diamniotic placenta (MCDAP). These twins thus have blood chimerism but are not chimeric in the other tissues studied. The mechanism for the chimerism could be due to either placental vascular anastamoses (after the development of the haematoblast stem cells) or due to an admixture of trophoblast cells during early blastocyst development. Such trophoblast cell admixtures would be restricted to the extraembryonic tissues so that general physical development in the fetus is normal and without somatic cell chimerism. This case in combination with others previously reported suggests that in IVF conceptions, the prevalence of blood chimerism associated with twinning, and the occurrence of DZ twinning associated with MCDAP, may be higher than previously thought.</abstract><cop>Oxford</cop><pub>Oxford University Press</pub><pmid>15375077</pmid><doi>10.1093/humrep/deh533</doi><tpages>6</tpages></addata></record> |
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| source | Oxford University Press Journals All Titles (1996-Current); MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals |
| subjects | Adult assisted hatching assisted reproduction techniques Biological and medical sciences Birth control blood chimerism Chimera Chorion Diseases in Twins - genetics Endocrine System - metabolism Female Fertilization in Vitro Fibroblasts - physiology Genitalia - abnormalities Gynecology. Andrology. Obstetrics Humans In Situ Hybridization, Fluorescence Infant Infant, Newborn IVF Lymphocytes - physiology Male Medical sciences Microsatellite Repeats monochorionic placenta Mosaicism Ovary - abnormalities Pregnancy Skin - cytology Sterility. Assisted procreation Twins, Dizygotic - genetics Ultrasonography, Prenatal |
| title | Blood lymphocyte chimerism associated with IVF and monochorionic dizygous twinning: Case report |
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