White matter impairments in autism, evidence from voxel-based morphometry and diffusion tensor imaging
Abstract This study explored white matter abnormalities in a group of Chinese children with high functioning autism (HFA). Twelve male children with HFA and ten matched typically developing children underwent diffusion tensor imaging (DTI) as well three-dimensional T1-weighted MRI for voxel-based mo...
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| Veröffentlicht in: | Brain research 2009-04, Vol.1265, p.171-177 |
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| creator | Ke, Xiaoyan Tang, Tianyu Hong, Shanshan Hang, Yueyue Zou, Bing Li, Huiguo Zhou, Zhenyu Ruan, Zongcai Lu, Zuhong Tao, Guotai Liu, Yijun |
| description | Abstract This study explored white matter abnormalities in a group of Chinese children with high functioning autism (HFA). Twelve male children with HFA and ten matched typically developing children underwent diffusion tensor imaging (DTI) as well three-dimensional T1-weighted MRI for voxel-based morphometry (VBM). We found a significant decrease of the white matter density in the right frontal lobe, left parietal lobe and right anterior cingulate and a significant increase in the right frontal lobe, left parietal lobe and left cingulate gyrus in the HFA group compared with the control group. The HFA group also had decreased FA in the frontal lobe and left temporal lobe. By combining DT-MRI FA and MRI volumetric analyses based on the VBM model, the results showed consistent white matter abnormalities in a group of Chinese children with HFA. |
| doi_str_mv | 10.1016/j.brainres.2009.02.013 |
| format | Article |
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Twelve male children with HFA and ten matched typically developing children underwent diffusion tensor imaging (DTI) as well three-dimensional T1-weighted MRI for voxel-based morphometry (VBM). We found a significant decrease of the white matter density in the right frontal lobe, left parietal lobe and right anterior cingulate and a significant increase in the right frontal lobe, left parietal lobe and left cingulate gyrus in the HFA group compared with the control group. The HFA group also had decreased FA in the frontal lobe and left temporal lobe. By combining DT-MRI FA and MRI volumetric analyses based on the VBM model, the results showed consistent white matter abnormalities in a group of Chinese children with HFA.</description><identifier>ISSN: 0006-8993</identifier><identifier>EISSN: 1872-6240</identifier><identifier>DOI: 10.1016/j.brainres.2009.02.013</identifier><identifier>PMID: 19233148</identifier><identifier>CODEN: BRREAP</identifier><language>eng</language><publisher>Amsterdam: Elsevier B.V</publisher><subject>Autistic disorder ; Autistic Disorder - pathology ; Autistic Disorder - physiopathology ; Biological and medical sciences ; Case-Control Studies ; Child ; Child clinical studies ; China ; Developmental disorders ; Diffusion Magnetic Resonance Imaging ; Diffusion tensor imaging ; Frontal Lobe - pathology ; Frontal Lobe - physiopathology ; Functional Laterality ; Gyrus Cinguli - pathology ; Gyrus Cinguli - physiopathology ; Humans ; Image Processing, Computer-Assisted ; Imaging, Three-Dimensional ; Infantile autism ; Male ; Medical sciences ; Neurology ; Parietal Lobe - pathology ; Parietal Lobe - physiopathology ; Psychology. Psychoanalysis. Psychiatry ; Psychopathology. Psychiatry ; Voxel-based morphometry ; White matter</subject><ispartof>Brain research, 2009-04, Vol.1265, p.171-177</ispartof><rights>Elsevier B.V.</rights><rights>2009 Elsevier B.V.</rights><rights>2009 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c548t-73a7e9cd5255275486e55dbc6d0d70847ada04011b86296e7d01cf3afbec05993</citedby><cites>FETCH-LOGICAL-c548t-73a7e9cd5255275486e55dbc6d0d70847ada04011b86296e7d01cf3afbec05993</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.brainres.2009.02.013$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>315,781,785,3551,27929,27930,46000</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=21374452$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/19233148$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Ke, Xiaoyan</creatorcontrib><creatorcontrib>Tang, Tianyu</creatorcontrib><creatorcontrib>Hong, Shanshan</creatorcontrib><creatorcontrib>Hang, Yueyue</creatorcontrib><creatorcontrib>Zou, Bing</creatorcontrib><creatorcontrib>Li, Huiguo</creatorcontrib><creatorcontrib>Zhou, Zhenyu</creatorcontrib><creatorcontrib>Ruan, Zongcai</creatorcontrib><creatorcontrib>Lu, Zuhong</creatorcontrib><creatorcontrib>Tao, Guotai</creatorcontrib><creatorcontrib>Liu, Yijun</creatorcontrib><title>White matter impairments in autism, evidence from voxel-based morphometry and diffusion tensor imaging</title><title>Brain research</title><addtitle>Brain Res</addtitle><description>Abstract This study explored white matter abnormalities in a group of Chinese children with high functioning autism (HFA). Twelve male children with HFA and ten matched typically developing children underwent diffusion tensor imaging (DTI) as well three-dimensional T1-weighted MRI for voxel-based morphometry (VBM). We found a significant decrease of the white matter density in the right frontal lobe, left parietal lobe and right anterior cingulate and a significant increase in the right frontal lobe, left parietal lobe and left cingulate gyrus in the HFA group compared with the control group. The HFA group also had decreased FA in the frontal lobe and left temporal lobe. By combining DT-MRI FA and MRI volumetric analyses based on the VBM model, the results showed consistent white matter abnormalities in a group of Chinese children with HFA.</description><subject>Autistic disorder</subject><subject>Autistic Disorder - pathology</subject><subject>Autistic Disorder - physiopathology</subject><subject>Biological and medical sciences</subject><subject>Case-Control Studies</subject><subject>Child</subject><subject>Child clinical studies</subject><subject>China</subject><subject>Developmental disorders</subject><subject>Diffusion Magnetic Resonance Imaging</subject><subject>Diffusion tensor imaging</subject><subject>Frontal Lobe - pathology</subject><subject>Frontal Lobe - physiopathology</subject><subject>Functional Laterality</subject><subject>Gyrus Cinguli - pathology</subject><subject>Gyrus Cinguli - physiopathology</subject><subject>Humans</subject><subject>Image Processing, Computer-Assisted</subject><subject>Imaging, Three-Dimensional</subject><subject>Infantile autism</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Neurology</subject><subject>Parietal Lobe - pathology</subject><subject>Parietal Lobe - physiopathology</subject><subject>Psychology. Psychoanalysis. Psychiatry</subject><subject>Psychopathology. Psychiatry</subject><subject>Voxel-based morphometry</subject><subject>White matter</subject><issn>0006-8993</issn><issn>1872-6240</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2009</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkk1v1DAQhi0EokvhL1S-wIksYyeOkwsCVXxJlTgA4mg59qT1ktiL7azYf4-jXUDi0pM11jPvfLxDyBWDLQPWvtpth6idj5i2HKDfAt8Cqx-QDeskr1rewEOyAYC26vq-viBPUtqVsK57eEwuWM_rmjXdhozf71xGOuucMVI377WLM_qcqPNUL9ml-SXFg7PoDdIxhpkewi-cqkEntHQOcX8XZszxSLW31LpxXJILnmb0KayK-tb526fk0ainhM_O7yX59v7d1-uP1c3nD5-u395URjRdrmStJfbGCi4El-WrRSHsYFoLVkLXSG01NMDY0LW8b1FaYGas9TigAVEGvSQvTrr7GH4umLKaXTI4TdpjWJJqiwpnorsX5ND0UkhewPYEmhhSijiqfSxDxaNioFYr1E79sUKtVijgqlhREq_OFZZhRvsv7bz7Ajw_AzoZPY1Re-PSX46zWjaNWDt4c-KwLO7gMKpk3GqHdRFNVja4-3t5_Z-EmZx3peoPPGLahSX6YotiKpUE9WU9nPVuoAfgZVv1b93TwMo</recordid><startdate>20090410</startdate><enddate>20090410</enddate><creator>Ke, Xiaoyan</creator><creator>Tang, Tianyu</creator><creator>Hong, Shanshan</creator><creator>Hang, Yueyue</creator><creator>Zou, Bing</creator><creator>Li, Huiguo</creator><creator>Zhou, Zhenyu</creator><creator>Ruan, Zongcai</creator><creator>Lu, Zuhong</creator><creator>Tao, Guotai</creator><creator>Liu, Yijun</creator><general>Elsevier B.V</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TK</scope><scope>7X8</scope></search><sort><creationdate>20090410</creationdate><title>White matter impairments in autism, evidence from voxel-based morphometry and diffusion tensor imaging</title><author>Ke, Xiaoyan ; Tang, Tianyu ; Hong, Shanshan ; Hang, Yueyue ; Zou, Bing ; Li, Huiguo ; Zhou, Zhenyu ; Ruan, Zongcai ; Lu, Zuhong ; Tao, Guotai ; Liu, Yijun</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c548t-73a7e9cd5255275486e55dbc6d0d70847ada04011b86296e7d01cf3afbec05993</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2009</creationdate><topic>Autistic disorder</topic><topic>Autistic Disorder - pathology</topic><topic>Autistic Disorder - physiopathology</topic><topic>Biological and medical sciences</topic><topic>Case-Control Studies</topic><topic>Child</topic><topic>Child clinical studies</topic><topic>China</topic><topic>Developmental disorders</topic><topic>Diffusion Magnetic Resonance Imaging</topic><topic>Diffusion tensor imaging</topic><topic>Frontal Lobe - pathology</topic><topic>Frontal Lobe - physiopathology</topic><topic>Functional Laterality</topic><topic>Gyrus Cinguli - pathology</topic><topic>Gyrus Cinguli - physiopathology</topic><topic>Humans</topic><topic>Image Processing, Computer-Assisted</topic><topic>Imaging, Three-Dimensional</topic><topic>Infantile autism</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Neurology</topic><topic>Parietal Lobe - pathology</topic><topic>Parietal Lobe - physiopathology</topic><topic>Psychology. Psychoanalysis. Psychiatry</topic><topic>Psychopathology. Psychiatry</topic><topic>Voxel-based morphometry</topic><topic>White matter</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Ke, Xiaoyan</creatorcontrib><creatorcontrib>Tang, Tianyu</creatorcontrib><creatorcontrib>Hong, Shanshan</creatorcontrib><creatorcontrib>Hang, Yueyue</creatorcontrib><creatorcontrib>Zou, Bing</creatorcontrib><creatorcontrib>Li, Huiguo</creatorcontrib><creatorcontrib>Zhou, Zhenyu</creatorcontrib><creatorcontrib>Ruan, Zongcai</creatorcontrib><creatorcontrib>Lu, Zuhong</creatorcontrib><creatorcontrib>Tao, Guotai</creatorcontrib><creatorcontrib>Liu, Yijun</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Neurosciences Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Brain research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Ke, Xiaoyan</au><au>Tang, Tianyu</au><au>Hong, Shanshan</au><au>Hang, Yueyue</au><au>Zou, Bing</au><au>Li, Huiguo</au><au>Zhou, Zhenyu</au><au>Ruan, Zongcai</au><au>Lu, Zuhong</au><au>Tao, Guotai</au><au>Liu, Yijun</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>White matter impairments in autism, evidence from voxel-based morphometry and diffusion tensor imaging</atitle><jtitle>Brain research</jtitle><addtitle>Brain Res</addtitle><date>2009-04-10</date><risdate>2009</risdate><volume>1265</volume><spage>171</spage><epage>177</epage><pages>171-177</pages><issn>0006-8993</issn><eissn>1872-6240</eissn><coden>BRREAP</coden><abstract>Abstract This study explored white matter abnormalities in a group of Chinese children with high functioning autism (HFA). Twelve male children with HFA and ten matched typically developing children underwent diffusion tensor imaging (DTI) as well three-dimensional T1-weighted MRI for voxel-based morphometry (VBM). We found a significant decrease of the white matter density in the right frontal lobe, left parietal lobe and right anterior cingulate and a significant increase in the right frontal lobe, left parietal lobe and left cingulate gyrus in the HFA group compared with the control group. The HFA group also had decreased FA in the frontal lobe and left temporal lobe. By combining DT-MRI FA and MRI volumetric analyses based on the VBM model, the results showed consistent white matter abnormalities in a group of Chinese children with HFA.</abstract><cop>Amsterdam</cop><pub>Elsevier B.V</pub><pmid>19233148</pmid><doi>10.1016/j.brainres.2009.02.013</doi><tpages>7</tpages></addata></record> |
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| subjects | Autistic disorder Autistic Disorder - pathology Autistic Disorder - physiopathology Biological and medical sciences Case-Control Studies Child Child clinical studies China Developmental disorders Diffusion Magnetic Resonance Imaging Diffusion tensor imaging Frontal Lobe - pathology Frontal Lobe - physiopathology Functional Laterality Gyrus Cinguli - pathology Gyrus Cinguli - physiopathology Humans Image Processing, Computer-Assisted Imaging, Three-Dimensional Infantile autism Male Medical sciences Neurology Parietal Lobe - pathology Parietal Lobe - physiopathology Psychology. Psychoanalysis. Psychiatry Psychopathology. Psychiatry Voxel-based morphometry White matter |
| title | White matter impairments in autism, evidence from voxel-based morphometry and diffusion tensor imaging |
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