Isolated Flavonoids against Mammary Tumour Cells LM2
The purpose of the present study was to investigate antitumour and anti-inflammatory activities of flavonoids isolated from Byrsonima crassa, Davilla elliptica and Mouriri pusa. The antitumour activity was measured by the MTT assay in murine mammary tumour cells (LM2) and the IC values of the fl avo...
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| Veröffentlicht in: | Zeitschrift für Naturforschung C. A journal of biosciences 2009-01, Vol.64 (1), p.32-36 |
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| creator | Carli, Camila B. de A. Matos, Djamile C. de Lopes, Flávia C. M. Maia, Danielle C. G. Dias, Maristela B. Sannomiya, Miriam Rodrigues, Clenilson M. Andreo, Marcio A. Vilegas, Wagner Colombo, Lucas L. Carlos, Iracilda Z. |
| description | The purpose of the present study was to investigate antitumour and anti-inflammatory activities of flavonoids isolated from Byrsonima crassa, Davilla elliptica and Mouriri pusa. The antitumour activity was measured by the MTT assay in murine mammary tumour cells (LM2) and the IC
values of the fl avonoids tested ranged from (31.5 ± 2.97) to (203.1 ± 5.9) μg/ml. The fl avonoids (myricetin-3-O-α-L-rhamnopyranoside) and
(quercetin-3-Ogalactopyranoside) from D. elliptica were the most active ones against the tumour cells. The same samples were tested to determine the inhibition of the release of nitric oxide (NO) and of the tumour necrosis factor-alpha (TNF-α) in murine macrophages by the Griess and ELISA sandwich assay, respectively. Almost all the samples showed inhibitory activity to the release of NO but not of TNF-α. Of all substances tested, flavonoids
(quercetin) and
(myricetin) may show promising activity in the treatment of murine breast cancer by immunomodulatory and antiproliferative activities. |
| doi_str_mv | 10.1515/znc-2009-1-206 |
| format | Article |
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values of the fl avonoids tested ranged from (31.5 ± 2.97) to (203.1 ± 5.9) μg/ml. The fl avonoids (myricetin-3-O-α-L-rhamnopyranoside) and
(quercetin-3-Ogalactopyranoside) from D. elliptica were the most active ones against the tumour cells. The same samples were tested to determine the inhibition of the release of nitric oxide (NO) and of the tumour necrosis factor-alpha (TNF-α) in murine macrophages by the Griess and ELISA sandwich assay, respectively. Almost all the samples showed inhibitory activity to the release of NO but not of TNF-α. Of all substances tested, flavonoids
(quercetin) and
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(quercetin-3-Ogalactopyranoside) from D. elliptica were the most active ones against the tumour cells. The same samples were tested to determine the inhibition of the release of nitric oxide (NO) and of the tumour necrosis factor-alpha (TNF-α) in murine macrophages by the Griess and ELISA sandwich assay, respectively. Almost all the samples showed inhibitory activity to the release of NO but not of TNF-α. Of all substances tested, flavonoids
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values of the fl avonoids tested ranged from (31.5 ± 2.97) to (203.1 ± 5.9) μg/ml. The fl avonoids (myricetin-3-O-α-L-rhamnopyranoside) and
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| subjects | Animals Antineoplastic Agents - isolation & purification Antineoplastic Agents - pharmacology Antitumour Activity Cell Line, Tumor Cell Survival - drug effects Cisplatin - pharmacology Cytokine Female Flavonoids Flavonoids - isolation & purification Flavonoids - pharmacology Malpighiaceae Mammary Neoplasms, Experimental - drug therapy Mammary Neoplasms, Experimental - pathology Mice Mice, Inbred BALB C Myrtaceae |
| title | Isolated Flavonoids against Mammary Tumour Cells LM2 |
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