Amphiregulin is much more abundantly expressed than transforming growth factor-alpha and epidermal growth factor in human follicular fluid obtained from patients undergoing in vitro fertilization–embryo transfer
Objective To identify the most important epidermal growth factor (EGF) receptor ligand in the LH or hCG signal pathway in human ovary. Design A retrospective clinical study. Setting Tertiary university hospital. Patient(s) Ninety-eight infertile patients who underwent IVF–embryo transfer. Interventi...
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| Veröffentlicht in: | Fertility and sterility 2009-04, Vol.91 (4), p.1035-1041 |
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| creator | Inoue, Yoshihito, M.D., Ph.D Miyamoto, Shingo, M.D., Ph.D Fukami, Tatsuya, M.D Shirota, Kyoko, M.D., Ph.D Yotsumoto, Fusanori, M.D Kawarabayashi, Tatsuhiko, M.D., Ph.D |
| description | Objective To identify the most important epidermal growth factor (EGF) receptor ligand in the LH or hCG signal pathway in human ovary. Design A retrospective clinical study. Setting Tertiary university hospital. Patient(s) Ninety-eight infertile patients who underwent IVF–embryo transfer. Intervention(s) Sera and follicular fluid were collected at the time of oocyte retrieval. The levels of EGF, transforming growth factor-alpha (TGFα), and amphiregulin (AR) were measured in follicular fluid and sera by using ELISA. Main Outcome Measure(s) The relationships between the level of AR and level of hCG, fertilization rate, and embryo quality. Result(s) Amphiregulin was abundantly expressed in follicular fluid after hCG stimulation. Although large differences were found between AR and both EGF and TGFα in follicular fluid, no significant difference was detected in the levels of the three EGF receptor ligands in sera. The level of AR was inversely correlated with the fertilization rate and hCG level, whereas little significant association was observed between the level of AR and embryo quality. Conclusion(s) Amphiregulin was expressed most dominantly among EGF receptor ligands tested and may mediate the hCG signal in human oocyte maturation. Elaborate interaction between AR and hCG may be required for an optimal oocyte maturation. |
| doi_str_mv | 10.1016/j.fertnstert.2008.01.014 |
| format | Article |
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Design A retrospective clinical study. Setting Tertiary university hospital. Patient(s) Ninety-eight infertile patients who underwent IVF–embryo transfer. Intervention(s) Sera and follicular fluid were collected at the time of oocyte retrieval. The levels of EGF, transforming growth factor-alpha (TGFα), and amphiregulin (AR) were measured in follicular fluid and sera by using ELISA. Main Outcome Measure(s) The relationships between the level of AR and level of hCG, fertilization rate, and embryo quality. Result(s) Amphiregulin was abundantly expressed in follicular fluid after hCG stimulation. Although large differences were found between AR and both EGF and TGFα in follicular fluid, no significant difference was detected in the levels of the three EGF receptor ligands in sera. The level of AR was inversely correlated with the fertilization rate and hCG level, whereas little significant association was observed between the level of AR and embryo quality. Conclusion(s) Amphiregulin was expressed most dominantly among EGF receptor ligands tested and may mediate the hCG signal in human oocyte maturation. Elaborate interaction between AR and hCG may be required for an optimal oocyte maturation.</description><identifier>ISSN: 0015-0282</identifier><identifier>EISSN: 1556-5653</identifier><identifier>DOI: 10.1016/j.fertnstert.2008.01.014</identifier><identifier>PMID: 18325497</identifier><identifier>CODEN: FESTAS</identifier><language>eng</language><publisher>New York, NY: Elsevier Inc</publisher><subject>Adult ; Amphiregulin ; Biological and medical sciences ; Blastocyst - chemistry ; Blastocyst - metabolism ; EGF Family of Proteins ; Embryo Implantation - physiology ; Embryo Transfer - methods ; epidermal growth factor ; Epidermal Growth Factor - analysis ; Epidermal Growth Factor - blood ; Epidermal Growth Factor - metabolism ; Female ; Fertilization in Vitro - methods ; Follicular Fluid - chemistry ; Follicular Fluid - metabolism ; Glycoproteins - analysis ; Glycoproteins - blood ; Glycoproteins - metabolism ; Gynecology. Andrology. Obstetrics ; human follicular fluid ; Humans ; Intercellular Signaling Peptides and Proteins - analysis ; Intercellular Signaling Peptides and Proteins - blood ; Intercellular Signaling Peptides and Proteins - metabolism ; Internal Medicine ; IVF-ET ; Medical sciences ; Obstetrics and Gynecology ; Pregnancy ; Quality Control ; Receptor, Epidermal Growth Factor - metabolism ; Retrospective Studies ; Transforming Growth Factor alpha - analysis ; Transforming Growth Factor alpha - blood ; Transforming Growth Factor alpha - metabolism ; transforming growth factor-alpha ; Young Adult</subject><ispartof>Fertility and sterility, 2009-04, Vol.91 (4), p.1035-1041</ispartof><rights>American Society for Reproductive Medicine</rights><rights>2009 American Society for Reproductive Medicine</rights><rights>2009 INIST-CNRS</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c507t-73a5db5c6e88c75701eb14b35cce57e5084131925c2c6fabedd2f3d074fc791d3</citedby><cites>FETCH-LOGICAL-c507t-73a5db5c6e88c75701eb14b35cce57e5084131925c2c6fabedd2f3d074fc791d3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0015028208000289$$EHTML$$P50$$Gelsevier$$Hfree_for_read</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65306</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=21385741$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/18325497$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Inoue, Yoshihito, M.D., Ph.D</creatorcontrib><creatorcontrib>Miyamoto, Shingo, M.D., Ph.D</creatorcontrib><creatorcontrib>Fukami, Tatsuya, M.D</creatorcontrib><creatorcontrib>Shirota, Kyoko, M.D., Ph.D</creatorcontrib><creatorcontrib>Yotsumoto, Fusanori, M.D</creatorcontrib><creatorcontrib>Kawarabayashi, Tatsuhiko, M.D., Ph.D</creatorcontrib><title>Amphiregulin is much more abundantly expressed than transforming growth factor-alpha and epidermal growth factor in human follicular fluid obtained from patients undergoing in vitro fertilization–embryo transfer</title><title>Fertility and sterility</title><addtitle>Fertil Steril</addtitle><description>Objective To identify the most important epidermal growth factor (EGF) receptor ligand in the LH or hCG signal pathway in human ovary. Design A retrospective clinical study. Setting Tertiary university hospital. Patient(s) Ninety-eight infertile patients who underwent IVF–embryo transfer. Intervention(s) Sera and follicular fluid were collected at the time of oocyte retrieval. The levels of EGF, transforming growth factor-alpha (TGFα), and amphiregulin (AR) were measured in follicular fluid and sera by using ELISA. Main Outcome Measure(s) The relationships between the level of AR and level of hCG, fertilization rate, and embryo quality. Result(s) Amphiregulin was abundantly expressed in follicular fluid after hCG stimulation. Although large differences were found between AR and both EGF and TGFα in follicular fluid, no significant difference was detected in the levels of the three EGF receptor ligands in sera. The level of AR was inversely correlated with the fertilization rate and hCG level, whereas little significant association was observed between the level of AR and embryo quality. Conclusion(s) Amphiregulin was expressed most dominantly among EGF receptor ligands tested and may mediate the hCG signal in human oocyte maturation. Elaborate interaction between AR and hCG may be required for an optimal oocyte maturation.</description><subject>Adult</subject><subject>Amphiregulin</subject><subject>Biological and medical sciences</subject><subject>Blastocyst - chemistry</subject><subject>Blastocyst - metabolism</subject><subject>EGF Family of Proteins</subject><subject>Embryo Implantation - physiology</subject><subject>Embryo Transfer - methods</subject><subject>epidermal growth factor</subject><subject>Epidermal Growth Factor - analysis</subject><subject>Epidermal Growth Factor - blood</subject><subject>Epidermal Growth Factor - metabolism</subject><subject>Female</subject><subject>Fertilization in Vitro - methods</subject><subject>Follicular Fluid - chemistry</subject><subject>Follicular Fluid - metabolism</subject><subject>Glycoproteins - analysis</subject><subject>Glycoproteins - blood</subject><subject>Glycoproteins - metabolism</subject><subject>Gynecology. Andrology. Obstetrics</subject><subject>human follicular fluid</subject><subject>Humans</subject><subject>Intercellular Signaling Peptides and Proteins - analysis</subject><subject>Intercellular Signaling Peptides and Proteins - blood</subject><subject>Intercellular Signaling Peptides and Proteins - metabolism</subject><subject>Internal Medicine</subject><subject>IVF-ET</subject><subject>Medical sciences</subject><subject>Obstetrics and Gynecology</subject><subject>Pregnancy</subject><subject>Quality Control</subject><subject>Receptor, Epidermal Growth Factor - metabolism</subject><subject>Retrospective Studies</subject><subject>Transforming Growth Factor alpha - analysis</subject><subject>Transforming Growth Factor alpha - blood</subject><subject>Transforming Growth Factor alpha - metabolism</subject><subject>transforming growth factor-alpha</subject><subject>Young Adult</subject><issn>0015-0282</issn><issn>1556-5653</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2009</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNUsuO1DAQjBCIHQZ-AfkCtwx2EieeC9Ky4iWtxAE4W47dnnhw7GA7C8OJf-Db-AG-BEcTsYITUsu-VHd1V1VRIIJ3BJP22XGnISQXU353FcZsh0mu5k6xIZS2JW1pfbfYYExoiStWXRQPYjxijFvSVfeLC8Lqijb7blP8vBynwQQ4zNY4ZCIaZzmg0QdAop-dEi7ZE4KvU4AYQaE0CIdSEC5qH0bjDugQ_Jc0IC1k8qEUdhoEEk4hmIyCMAr7NwJlmmEe8xTtrTVytiIgbWejkO-TMC6T6OBHNIlkwKWI8hYQDn7hyr03JgWPlvONNd8yxrtf33_A2IeTXxeD8LC4p4WN8Gj9t8XHVy8_XL0pr9-9fnt1eV1KirtUdrWgqqeyBcZkRztMoCdNX1MpgXZAMWtITfYVlZVstehBqUrXCneNlt2eqHpbPD3PnYL_PENMfDRRgrXCgZ8jbzvMSENZBrIzUAYfYwDNp2BGEU6cYL5Yyo_81lK-WMoxydXk1scrx9yPoG4bVw8z4MkKEFEKq7MG0sQ_uIrUjHb5kG3x4oyDrMiNgcCjzApLUNl_mbjy5n-2ef7PEJmDYzLvJzhBPPo5uKw4JzxWHPP3SwSXBGKW01exff0bDfrjFw</recordid><startdate>20090401</startdate><enddate>20090401</enddate><creator>Inoue, Yoshihito, M.D., Ph.D</creator><creator>Miyamoto, Shingo, M.D., Ph.D</creator><creator>Fukami, Tatsuya, M.D</creator><creator>Shirota, Kyoko, M.D., Ph.D</creator><creator>Yotsumoto, Fusanori, M.D</creator><creator>Kawarabayashi, Tatsuhiko, M.D., Ph.D</creator><general>Elsevier Inc</general><general>Elsevier</general><scope>6I.</scope><scope>AAFTH</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20090401</creationdate><title>Amphiregulin is much more abundantly expressed than transforming growth factor-alpha and epidermal growth factor in human follicular fluid obtained from patients undergoing in vitro fertilization–embryo transfer</title><author>Inoue, Yoshihito, M.D., Ph.D ; Miyamoto, Shingo, M.D., Ph.D ; Fukami, Tatsuya, M.D ; Shirota, Kyoko, M.D., Ph.D ; Yotsumoto, Fusanori, M.D ; Kawarabayashi, Tatsuhiko, M.D., Ph.D</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c507t-73a5db5c6e88c75701eb14b35cce57e5084131925c2c6fabedd2f3d074fc791d3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2009</creationdate><topic>Adult</topic><topic>Amphiregulin</topic><topic>Biological and medical sciences</topic><topic>Blastocyst - chemistry</topic><topic>Blastocyst - metabolism</topic><topic>EGF Family of Proteins</topic><topic>Embryo Implantation - physiology</topic><topic>Embryo Transfer - methods</topic><topic>epidermal growth factor</topic><topic>Epidermal Growth Factor - analysis</topic><topic>Epidermal Growth Factor - blood</topic><topic>Epidermal Growth Factor - metabolism</topic><topic>Female</topic><topic>Fertilization in Vitro - methods</topic><topic>Follicular Fluid - chemistry</topic><topic>Follicular Fluid - metabolism</topic><topic>Glycoproteins - analysis</topic><topic>Glycoproteins - blood</topic><topic>Glycoproteins - metabolism</topic><topic>Gynecology. Andrology. Obstetrics</topic><topic>human follicular fluid</topic><topic>Humans</topic><topic>Intercellular Signaling Peptides and Proteins - analysis</topic><topic>Intercellular Signaling Peptides and Proteins - blood</topic><topic>Intercellular Signaling Peptides and Proteins - metabolism</topic><topic>Internal Medicine</topic><topic>IVF-ET</topic><topic>Medical sciences</topic><topic>Obstetrics and Gynecology</topic><topic>Pregnancy</topic><topic>Quality Control</topic><topic>Receptor, Epidermal Growth Factor - metabolism</topic><topic>Retrospective Studies</topic><topic>Transforming Growth Factor alpha - analysis</topic><topic>Transforming Growth Factor alpha - blood</topic><topic>Transforming Growth Factor alpha - metabolism</topic><topic>transforming growth factor-alpha</topic><topic>Young Adult</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Inoue, Yoshihito, M.D., Ph.D</creatorcontrib><creatorcontrib>Miyamoto, Shingo, M.D., Ph.D</creatorcontrib><creatorcontrib>Fukami, Tatsuya, M.D</creatorcontrib><creatorcontrib>Shirota, Kyoko, M.D., Ph.D</creatorcontrib><creatorcontrib>Yotsumoto, Fusanori, M.D</creatorcontrib><creatorcontrib>Kawarabayashi, Tatsuhiko, M.D., Ph.D</creatorcontrib><collection>ScienceDirect Open Access Titles</collection><collection>Elsevier:ScienceDirect:Open Access</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Fertility and sterility</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Inoue, Yoshihito, M.D., Ph.D</au><au>Miyamoto, Shingo, M.D., Ph.D</au><au>Fukami, Tatsuya, M.D</au><au>Shirota, Kyoko, M.D., Ph.D</au><au>Yotsumoto, Fusanori, M.D</au><au>Kawarabayashi, Tatsuhiko, M.D., Ph.D</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Amphiregulin is much more abundantly expressed than transforming growth factor-alpha and epidermal growth factor in human follicular fluid obtained from patients undergoing in vitro fertilization–embryo transfer</atitle><jtitle>Fertility and sterility</jtitle><addtitle>Fertil Steril</addtitle><date>2009-04-01</date><risdate>2009</risdate><volume>91</volume><issue>4</issue><spage>1035</spage><epage>1041</epage><pages>1035-1041</pages><issn>0015-0282</issn><eissn>1556-5653</eissn><coden>FESTAS</coden><abstract>Objective To identify the most important epidermal growth factor (EGF) receptor ligand in the LH or hCG signal pathway in human ovary. Design A retrospective clinical study. Setting Tertiary university hospital. Patient(s) Ninety-eight infertile patients who underwent IVF–embryo transfer. Intervention(s) Sera and follicular fluid were collected at the time of oocyte retrieval. The levels of EGF, transforming growth factor-alpha (TGFα), and amphiregulin (AR) were measured in follicular fluid and sera by using ELISA. Main Outcome Measure(s) The relationships between the level of AR and level of hCG, fertilization rate, and embryo quality. Result(s) Amphiregulin was abundantly expressed in follicular fluid after hCG stimulation. Although large differences were found between AR and both EGF and TGFα in follicular fluid, no significant difference was detected in the levels of the three EGF receptor ligands in sera. The level of AR was inversely correlated with the fertilization rate and hCG level, whereas little significant association was observed between the level of AR and embryo quality. Conclusion(s) Amphiregulin was expressed most dominantly among EGF receptor ligands tested and may mediate the hCG signal in human oocyte maturation. Elaborate interaction between AR and hCG may be required for an optimal oocyte maturation.</abstract><cop>New York, NY</cop><pub>Elsevier Inc</pub><pmid>18325497</pmid><doi>10.1016/j.fertnstert.2008.01.014</doi><tpages>7</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | Fertility and sterility, 2009-04, Vol.91 (4), p.1035-1041 |
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| source | MEDLINE; Elsevier ScienceDirect Journals; EZB-FREE-00999 freely available EZB journals; Alma/SFX Local Collection |
| subjects | Adult Amphiregulin Biological and medical sciences Blastocyst - chemistry Blastocyst - metabolism EGF Family of Proteins Embryo Implantation - physiology Embryo Transfer - methods epidermal growth factor Epidermal Growth Factor - analysis Epidermal Growth Factor - blood Epidermal Growth Factor - metabolism Female Fertilization in Vitro - methods Follicular Fluid - chemistry Follicular Fluid - metabolism Glycoproteins - analysis Glycoproteins - blood Glycoproteins - metabolism Gynecology. Andrology. Obstetrics human follicular fluid Humans Intercellular Signaling Peptides and Proteins - analysis Intercellular Signaling Peptides and Proteins - blood Intercellular Signaling Peptides and Proteins - metabolism Internal Medicine IVF-ET Medical sciences Obstetrics and Gynecology Pregnancy Quality Control Receptor, Epidermal Growth Factor - metabolism Retrospective Studies Transforming Growth Factor alpha - analysis Transforming Growth Factor alpha - blood Transforming Growth Factor alpha - metabolism transforming growth factor-alpha Young Adult |
| title | Amphiregulin is much more abundantly expressed than transforming growth factor-alpha and epidermal growth factor in human follicular fluid obtained from patients undergoing in vitro fertilization–embryo transfer |
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