DNA Complexing Lipopolythiourea

We present a neutral lipopolythiourea (DTTU) as a potential DNA-binding agent. Light scattering experiments showed that mixing a lipopolythiourea with dipalmitoylphosphatidylcholine (DPPC/DTTU) led to small particles with sizes ranging from 100 to 150 nm at optimum conditions. Setting a fixed DNA am...

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Veröffentlicht in:	Bioconjugate chemistry 2004-11, Vol.15 (6), p.1342-1348
Hauptverfasser:	Tranchant, Isabelle, Mignet, Nathalie, Crozat, Estelle, Leblond, Jeanne, Girard, Christian, Scherman, Daniel, Herscovici, Jean
Format:	Artikel
Sprache:	eng
Schlagworte:	1,2-Dipalmitoylphosphatidylcholine - chemistry 1,2-Dipalmitoylphosphatidylcholine - metabolism Animals Biological Availability Carcinoma, Lewis Lung - drug therapy Carcinoma, Lewis Lung - metabolism Deoxyribonucleic acid DNA DNA - administration & dosage DNA - chemistry DNA - metabolism Female Lipids Liposomes Mice Mice, Inbred C57BL Neoplasm Transplantation Pharmacology Thiourea - administration & dosage Thiourea - chemical synthesis Thiourea - metabolism
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