Inappropriate gonadotropin secretion in polycystic ovary syndrome
Objective To evaluate inappropriate gonadotropin secretion in women with polycystic ovary syndrome (PCOS). Design Retrospective study. Setting Academic tertiary center. Patient(s) A total of 373 women were classified into three groups: [1] healthy control women (n = 48); [2] women who were positive...
Gespeichert in:
| Veröffentlicht in: | Fertility and sterility 2009-04, Vol.91 (4), p.1168-1174 |
|---|---|
| Hauptverfasser: | , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 1174 |
|---|---|
| container_issue | 4 |
| container_start_page | 1168 |
| container_title | Fertility and sterility |
| container_volume | 91 |
| creator | Hsu, Ming-I, M.D Liou, Tsan-Hon, M.D Liang, So-Jung, M.D Su, Hung-Wen, M.D Wu, Chien-Hua, Ph.D Hsu, Chun-Sen, M.D |
| description | Objective To evaluate inappropriate gonadotropin secretion in women with polycystic ovary syndrome (PCOS). Design Retrospective study. Setting Academic tertiary center. Patient(s) A total of 373 women were classified into three groups: [1] healthy control women (n = 48); [2] women who were positive for PCOS risk factor; and [3] women with PCOS (n = 251). Intervention(s) None. Main Outcome Measure(s) Gonadotropin levels, LH-FSH ratio, body mass index, and clinical and/or biochemical presentations of PCOS. Result(s) The area under the receiver operating characteristic curve, used to predict PCOS for the LH-FSH ratio, showed similar diagnostic performance to total T and average ovarian volume. The LH-FSH ratio exhibits greater observed accuracy than total T and average ovarian volume for evaluation of women with oligomenorrhea or anovulation. An LH-FSH ratio of >1 presented the best combination of sensitivity and specificity. Body mass index was positively correlated with total T in non-PCOS and PCOS groups; however, body mass index was negatively correlated with LH in PCOS but showed no correlation in non-PCOS subjects. Conclusion(s) The LH-FSH ratio is a valuable diagnostic tool in evaluating women with PCOS and oligomenorrhea or anovulation, and an LH-FSH ratio of >1 may be used as a decision threshold. The link between body mass index and LH may provide clues for further understanding the pathological milieu of PCOS. |
| doi_str_mv | 10.1016/j.fertnstert.2008.01.036 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_67081224</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>S0015028208000435</els_id><sourcerecordid>67081224</sourcerecordid><originalsourceid>FETCH-LOGICAL-c507t-54f981ae62bd05a51f9da5d0a50d637f57d9f42ee47e1d4d739e30dc5b2890093</originalsourceid><addsrcrecordid>eNqNkc9rFDEUgIModlv9F2QuepvxJZlkMhehLbUtFDyo55BN3kjW2WRNsoX575tlFws99ZLw4Hu_vkdIQ6GjQOXXTTdhKiGX-nYMQHVAO-DyDVlRIWQrpOBvyQqAihaYYmfkPOcNAEg6sPfkjCrOhAC1Ipf3wex2Ke6SNwWbPzEYF0uNfWgy2oTFx9DUYBfnxS65eNvER5OWJi_BpbjFD-TdZOaMH0__Bfn9_ebX9V378OP2_vryobUChtKKfhoVNSjZ2oEwgk6jM8KBEeAkHyYxuHHqGWI_IHW9G_iIHJwVa6ZGgJFfkC_HunXaf3vMRW99tjjPJmDcZy0HUJSxvoLqCNoUc0446brcto6sKeiDPr3Rz_r0QZ8Gqqu-mvrp1GO_3qJ7Tjz5qsDnE2CyNfOUTLA-_-cY5UoMklbu6shhNfLoMelsPQaLzie0RbvoXzPNtxdF7OyDr33_4oJ5E_cpVOOa6sw06J-Hcx-uDapeuueCPwFaYqlU</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>67081224</pqid></control><display><type>article</type><title>Inappropriate gonadotropin secretion in polycystic ovary syndrome</title><source>MEDLINE</source><source>Elsevier ScienceDirect Journals</source><source>EZB-FREE-00999 freely available EZB journals</source><source>Alma/SFX Local Collection</source><creator>Hsu, Ming-I, M.D ; Liou, Tsan-Hon, M.D ; Liang, So-Jung, M.D ; Su, Hung-Wen, M.D ; Wu, Chien-Hua, Ph.D ; Hsu, Chun-Sen, M.D</creator><creatorcontrib>Hsu, Ming-I, M.D ; Liou, Tsan-Hon, M.D ; Liang, So-Jung, M.D ; Su, Hung-Wen, M.D ; Wu, Chien-Hua, Ph.D ; Hsu, Chun-Sen, M.D</creatorcontrib><description>Objective To evaluate inappropriate gonadotropin secretion in women with polycystic ovary syndrome (PCOS). Design Retrospective study. Setting Academic tertiary center. Patient(s) A total of 373 women were classified into three groups: [1] healthy control women (n = 48); [2] women who were positive for PCOS risk factor; and [3] women with PCOS (n = 251). Intervention(s) None. Main Outcome Measure(s) Gonadotropin levels, LH-FSH ratio, body mass index, and clinical and/or biochemical presentations of PCOS. Result(s) The area under the receiver operating characteristic curve, used to predict PCOS for the LH-FSH ratio, showed similar diagnostic performance to total T and average ovarian volume. The LH-FSH ratio exhibits greater observed accuracy than total T and average ovarian volume for evaluation of women with oligomenorrhea or anovulation. An LH-FSH ratio of >1 presented the best combination of sensitivity and specificity. Body mass index was positively correlated with total T in non-PCOS and PCOS groups; however, body mass index was negatively correlated with LH in PCOS but showed no correlation in non-PCOS subjects. Conclusion(s) The LH-FSH ratio is a valuable diagnostic tool in evaluating women with PCOS and oligomenorrhea or anovulation, and an LH-FSH ratio of >1 may be used as a decision threshold. The link between body mass index and LH may provide clues for further understanding the pathological milieu of PCOS.</description><identifier>ISSN: 0015-0282</identifier><identifier>EISSN: 1556-5653</identifier><identifier>DOI: 10.1016/j.fertnstert.2008.01.036</identifier><identifier>PMID: 18325508</identifier><identifier>CODEN: FESTAS</identifier><language>eng</language><publisher>New York, NY: Elsevier Inc</publisher><subject>Adolescent ; Adult ; Biological and medical sciences ; Body Mass Index ; Case-Control Studies ; diagnosis ; Female ; Female genital diseases ; Follicle Stimulating Hormone - blood ; gonadotropin ; Gonadotropins - blood ; Gonadotropins - secretion ; Gynecology. Andrology. Obstetrics ; Humans ; Internal Medicine ; LH to FSH ratio ; Luteinizing Hormone - blood ; Medical sciences ; Menstrual Cycle - blood ; Menstrual Cycle - metabolism ; Metabolic diseases ; Non tumoral diseases ; Obesity ; Obesity - blood ; Obesity - epidemiology ; Obstetrics and Gynecology ; oligomenorrhea ; PCOS ; Polycystic Ovary Syndrome - blood ; Polycystic Ovary Syndrome - diagnosis ; Polycystic Ovary Syndrome - epidemiology ; Polycystic Ovary Syndrome - secretion ; Prolactin - blood ; Retrospective Studies ; Sensitivity and Specificity ; Young Adult</subject><ispartof>Fertility and sterility, 2009-04, Vol.91 (4), p.1168-1174</ispartof><rights>American Society for Reproductive Medicine</rights><rights>2009 American Society for Reproductive Medicine</rights><rights>2009 INIST-CNRS</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c507t-54f981ae62bd05a51f9da5d0a50d637f57d9f42ee47e1d4d739e30dc5b2890093</citedby><cites>FETCH-LOGICAL-c507t-54f981ae62bd05a51f9da5d0a50d637f57d9f42ee47e1d4d739e30dc5b2890093</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0015028208000435$$EHTML$$P50$$Gelsevier$$Hfree_for_read</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65306</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=21385761$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/18325508$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Hsu, Ming-I, M.D</creatorcontrib><creatorcontrib>Liou, Tsan-Hon, M.D</creatorcontrib><creatorcontrib>Liang, So-Jung, M.D</creatorcontrib><creatorcontrib>Su, Hung-Wen, M.D</creatorcontrib><creatorcontrib>Wu, Chien-Hua, Ph.D</creatorcontrib><creatorcontrib>Hsu, Chun-Sen, M.D</creatorcontrib><title>Inappropriate gonadotropin secretion in polycystic ovary syndrome</title><title>Fertility and sterility</title><addtitle>Fertil Steril</addtitle><description>Objective To evaluate inappropriate gonadotropin secretion in women with polycystic ovary syndrome (PCOS). Design Retrospective study. Setting Academic tertiary center. Patient(s) A total of 373 women were classified into three groups: [1] healthy control women (n = 48); [2] women who were positive for PCOS risk factor; and [3] women with PCOS (n = 251). Intervention(s) None. Main Outcome Measure(s) Gonadotropin levels, LH-FSH ratio, body mass index, and clinical and/or biochemical presentations of PCOS. Result(s) The area under the receiver operating characteristic curve, used to predict PCOS for the LH-FSH ratio, showed similar diagnostic performance to total T and average ovarian volume. The LH-FSH ratio exhibits greater observed accuracy than total T and average ovarian volume for evaluation of women with oligomenorrhea or anovulation. An LH-FSH ratio of >1 presented the best combination of sensitivity and specificity. Body mass index was positively correlated with total T in non-PCOS and PCOS groups; however, body mass index was negatively correlated with LH in PCOS but showed no correlation in non-PCOS subjects. Conclusion(s) The LH-FSH ratio is a valuable diagnostic tool in evaluating women with PCOS and oligomenorrhea or anovulation, and an LH-FSH ratio of >1 may be used as a decision threshold. The link between body mass index and LH may provide clues for further understanding the pathological milieu of PCOS.</description><subject>Adolescent</subject><subject>Adult</subject><subject>Biological and medical sciences</subject><subject>Body Mass Index</subject><subject>Case-Control Studies</subject><subject>diagnosis</subject><subject>Female</subject><subject>Female genital diseases</subject><subject>Follicle Stimulating Hormone - blood</subject><subject>gonadotropin</subject><subject>Gonadotropins - blood</subject><subject>Gonadotropins - secretion</subject><subject>Gynecology. Andrology. Obstetrics</subject><subject>Humans</subject><subject>Internal Medicine</subject><subject>LH to FSH ratio</subject><subject>Luteinizing Hormone - blood</subject><subject>Medical sciences</subject><subject>Menstrual Cycle - blood</subject><subject>Menstrual Cycle - metabolism</subject><subject>Metabolic diseases</subject><subject>Non tumoral diseases</subject><subject>Obesity</subject><subject>Obesity - blood</subject><subject>Obesity - epidemiology</subject><subject>Obstetrics and Gynecology</subject><subject>oligomenorrhea</subject><subject>PCOS</subject><subject>Polycystic Ovary Syndrome - blood</subject><subject>Polycystic Ovary Syndrome - diagnosis</subject><subject>Polycystic Ovary Syndrome - epidemiology</subject><subject>Polycystic Ovary Syndrome - secretion</subject><subject>Prolactin - blood</subject><subject>Retrospective Studies</subject><subject>Sensitivity and Specificity</subject><subject>Young Adult</subject><issn>0015-0282</issn><issn>1556-5653</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2009</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkc9rFDEUgIModlv9F2QuepvxJZlkMhehLbUtFDyo55BN3kjW2WRNsoX575tlFws99ZLw4Hu_vkdIQ6GjQOXXTTdhKiGX-nYMQHVAO-DyDVlRIWQrpOBvyQqAihaYYmfkPOcNAEg6sPfkjCrOhAC1Ipf3wex2Ke6SNwWbPzEYF0uNfWgy2oTFx9DUYBfnxS65eNvER5OWJi_BpbjFD-TdZOaMH0__Bfn9_ebX9V378OP2_vryobUChtKKfhoVNSjZ2oEwgk6jM8KBEeAkHyYxuHHqGWI_IHW9G_iIHJwVa6ZGgJFfkC_HunXaf3vMRW99tjjPJmDcZy0HUJSxvoLqCNoUc0446brcto6sKeiDPr3Rz_r0QZ8Gqqu-mvrp1GO_3qJ7Tjz5qsDnE2CyNfOUTLA-_-cY5UoMklbu6shhNfLoMelsPQaLzie0RbvoXzPNtxdF7OyDr33_4oJ5E_cpVOOa6sw06J-Hcx-uDapeuueCPwFaYqlU</recordid><startdate>20090401</startdate><enddate>20090401</enddate><creator>Hsu, Ming-I, M.D</creator><creator>Liou, Tsan-Hon, M.D</creator><creator>Liang, So-Jung, M.D</creator><creator>Su, Hung-Wen, M.D</creator><creator>Wu, Chien-Hua, Ph.D</creator><creator>Hsu, Chun-Sen, M.D</creator><general>Elsevier Inc</general><general>Elsevier</general><scope>6I.</scope><scope>AAFTH</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20090401</creationdate><title>Inappropriate gonadotropin secretion in polycystic ovary syndrome</title><author>Hsu, Ming-I, M.D ; Liou, Tsan-Hon, M.D ; Liang, So-Jung, M.D ; Su, Hung-Wen, M.D ; Wu, Chien-Hua, Ph.D ; Hsu, Chun-Sen, M.D</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c507t-54f981ae62bd05a51f9da5d0a50d637f57d9f42ee47e1d4d739e30dc5b2890093</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2009</creationdate><topic>Adolescent</topic><topic>Adult</topic><topic>Biological and medical sciences</topic><topic>Body Mass Index</topic><topic>Case-Control Studies</topic><topic>diagnosis</topic><topic>Female</topic><topic>Female genital diseases</topic><topic>Follicle Stimulating Hormone - blood</topic><topic>gonadotropin</topic><topic>Gonadotropins - blood</topic><topic>Gonadotropins - secretion</topic><topic>Gynecology. Andrology. Obstetrics</topic><topic>Humans</topic><topic>Internal Medicine</topic><topic>LH to FSH ratio</topic><topic>Luteinizing Hormone - blood</topic><topic>Medical sciences</topic><topic>Menstrual Cycle - blood</topic><topic>Menstrual Cycle - metabolism</topic><topic>Metabolic diseases</topic><topic>Non tumoral diseases</topic><topic>Obesity</topic><topic>Obesity - blood</topic><topic>Obesity - epidemiology</topic><topic>Obstetrics and Gynecology</topic><topic>oligomenorrhea</topic><topic>PCOS</topic><topic>Polycystic Ovary Syndrome - blood</topic><topic>Polycystic Ovary Syndrome - diagnosis</topic><topic>Polycystic Ovary Syndrome - epidemiology</topic><topic>Polycystic Ovary Syndrome - secretion</topic><topic>Prolactin - blood</topic><topic>Retrospective Studies</topic><topic>Sensitivity and Specificity</topic><topic>Young Adult</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Hsu, Ming-I, M.D</creatorcontrib><creatorcontrib>Liou, Tsan-Hon, M.D</creatorcontrib><creatorcontrib>Liang, So-Jung, M.D</creatorcontrib><creatorcontrib>Su, Hung-Wen, M.D</creatorcontrib><creatorcontrib>Wu, Chien-Hua, Ph.D</creatorcontrib><creatorcontrib>Hsu, Chun-Sen, M.D</creatorcontrib><collection>ScienceDirect Open Access Titles</collection><collection>Elsevier:ScienceDirect:Open Access</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Fertility and sterility</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Hsu, Ming-I, M.D</au><au>Liou, Tsan-Hon, M.D</au><au>Liang, So-Jung, M.D</au><au>Su, Hung-Wen, M.D</au><au>Wu, Chien-Hua, Ph.D</au><au>Hsu, Chun-Sen, M.D</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Inappropriate gonadotropin secretion in polycystic ovary syndrome</atitle><jtitle>Fertility and sterility</jtitle><addtitle>Fertil Steril</addtitle><date>2009-04-01</date><risdate>2009</risdate><volume>91</volume><issue>4</issue><spage>1168</spage><epage>1174</epage><pages>1168-1174</pages><issn>0015-0282</issn><eissn>1556-5653</eissn><coden>FESTAS</coden><abstract>Objective To evaluate inappropriate gonadotropin secretion in women with polycystic ovary syndrome (PCOS). Design Retrospective study. Setting Academic tertiary center. Patient(s) A total of 373 women were classified into three groups: [1] healthy control women (n = 48); [2] women who were positive for PCOS risk factor; and [3] women with PCOS (n = 251). Intervention(s) None. Main Outcome Measure(s) Gonadotropin levels, LH-FSH ratio, body mass index, and clinical and/or biochemical presentations of PCOS. Result(s) The area under the receiver operating characteristic curve, used to predict PCOS for the LH-FSH ratio, showed similar diagnostic performance to total T and average ovarian volume. The LH-FSH ratio exhibits greater observed accuracy than total T and average ovarian volume for evaluation of women with oligomenorrhea or anovulation. An LH-FSH ratio of >1 presented the best combination of sensitivity and specificity. Body mass index was positively correlated with total T in non-PCOS and PCOS groups; however, body mass index was negatively correlated with LH in PCOS but showed no correlation in non-PCOS subjects. Conclusion(s) The LH-FSH ratio is a valuable diagnostic tool in evaluating women with PCOS and oligomenorrhea or anovulation, and an LH-FSH ratio of >1 may be used as a decision threshold. The link between body mass index and LH may provide clues for further understanding the pathological milieu of PCOS.</abstract><cop>New York, NY</cop><pub>Elsevier Inc</pub><pmid>18325508</pmid><doi>10.1016/j.fertnstert.2008.01.036</doi><tpages>7</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0015-0282 |
| ispartof | Fertility and sterility, 2009-04, Vol.91 (4), p.1168-1174 |
| issn | 0015-0282 1556-5653 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_67081224 |
| source | MEDLINE; Elsevier ScienceDirect Journals; EZB-FREE-00999 freely available EZB journals; Alma/SFX Local Collection |
| subjects | Adolescent Adult Biological and medical sciences Body Mass Index Case-Control Studies diagnosis Female Female genital diseases Follicle Stimulating Hormone - blood gonadotropin Gonadotropins - blood Gonadotropins - secretion Gynecology. Andrology. Obstetrics Humans Internal Medicine LH to FSH ratio Luteinizing Hormone - blood Medical sciences Menstrual Cycle - blood Menstrual Cycle - metabolism Metabolic diseases Non tumoral diseases Obesity Obesity - blood Obesity - epidemiology Obstetrics and Gynecology oligomenorrhea PCOS Polycystic Ovary Syndrome - blood Polycystic Ovary Syndrome - diagnosis Polycystic Ovary Syndrome - epidemiology Polycystic Ovary Syndrome - secretion Prolactin - blood Retrospective Studies Sensitivity and Specificity Young Adult |
| title | Inappropriate gonadotropin secretion in polycystic ovary syndrome |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-06T21%3A23%3A02IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Inappropriate%20gonadotropin%20secretion%20in%20polycystic%20ovary%20syndrome&rft.jtitle=Fertility%20and%20sterility&rft.au=Hsu,%20Ming-I,%20M.D&rft.date=2009-04-01&rft.volume=91&rft.issue=4&rft.spage=1168&rft.epage=1174&rft.pages=1168-1174&rft.issn=0015-0282&rft.eissn=1556-5653&rft.coden=FESTAS&rft_id=info:doi/10.1016/j.fertnstert.2008.01.036&rft_dat=%3Cproquest_cross%3E67081224%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=67081224&rft_id=info:pmid/18325508&rft_els_id=S0015028208000435&rfr_iscdi=true |