Conversion of human-selective PPARalpha agonists to human/mouse dual agonists: a molecular modeling analysis

To understand the species selectivity in a series of alpha-methyl-alpha-phenoxy carboxylic acid PPARalpha/gamma dual agonists (1-11), structure-based molecular modeling was carried out in the ligand binding pockets of both human and mouse PPARalpha. This study suggested that interaction of both 4-ph...

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Veröffentlicht in:	Bioorganic & medicinal chemistry letters 2004-12, Vol.14 (24), p.6113-6116
Hauptverfasser:	Wang, Minmin, Winneroski, Leonard L, Ardecky, Robert J, Babine, Robert E, Brooks, Dawn A, Etgen, Garret J, Hutchison, Darrell R, Kauffman, Raymond F, Kunkel, Aaron, Mais, Dale E, Montrose-Rafizadeh, Chahrzad, Ogilvie, Kathleen M, Oldham, Brian A, Peters, Mary K, Rito, Christopher J, Rungta, Deepa K, Tripp, Allie E, Wilson, Sarah B, Xu, Yanping, Zink, Richard W, McCarthy, James R
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Cinnamates - chemical synthesis Cinnamates - chemistry Cinnamates - pharmacology Drug Design Humans Ligands Mice Models, Molecular Molecular Structure PPAR alpha - agonists Species Specificity Structure-Activity Relationship
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