The International Prognostic Index predicts outcome in aggressive adult T-cell leukemia/lymphoma: analysis of 126 patients from the International Peripheral T-cell Lymphoma Project
Background: The International Peripheral T-cell Lymphoma Project was organized to better understand the T-cell and natural killer (NK) cell lymphomas, and our task is to present the clinicopathologic correlations and therapeutic results for adult T-cell leukemia/lymphoma (ATL). Patients and methods:...
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| Veröffentlicht in: | Annals of oncology 2009-04, Vol.20 (4), p.715-721 |
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| creator | Suzumiya, J. Ohshima, K. Tamura, K. Karube, K. Uike, N. Tobinai, K. Gascoyne, R. D. Vose, J. M. Armitage, J. O. Weisenburger, D. D. |
| description | Background: The International Peripheral T-cell Lymphoma Project was organized to better understand the T-cell and natural killer (NK) cell lymphomas, and our task is to present the clinicopathologic correlations and therapeutic results for adult T-cell leukemia/lymphoma (ATL). Patients and methods: Among 1153 patients with T-cell or NK cell lymphomas, 126 patients (9.6%) with ATL were represented in this project. All were categorized as aggressive ATL, i.e. acute or lymphoma type, and 87% fell into the lymphoma type. Results: The median age was 62 years and the male to female ratio was 1.2 : 1. Significant prognostic factors for overall survival (OS) by univariate analysis were the presence of B symptoms (P = 0.018), platelet count |
| doi_str_mv | 10.1093/annonc/mdn696 |
| format | Article |
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D. ; Vose, J. M. ; Armitage, J. O. ; Weisenburger, D. D.</creator><creatorcontrib>Suzumiya, J. ; Ohshima, K. ; Tamura, K. ; Karube, K. ; Uike, N. ; Tobinai, K. ; Gascoyne, R. D. ; Vose, J. M. ; Armitage, J. O. ; Weisenburger, D. D. ; International Peripheral T-Cell Lymphoma Project</creatorcontrib><description>Background: The International Peripheral T-cell Lymphoma Project was organized to better understand the T-cell and natural killer (NK) cell lymphomas, and our task is to present the clinicopathologic correlations and therapeutic results for adult T-cell leukemia/lymphoma (ATL). Patients and methods: Among 1153 patients with T-cell or NK cell lymphomas, 126 patients (9.6%) with ATL were represented in this project. All were categorized as aggressive ATL, i.e. acute or lymphoma type, and 87% fell into the lymphoma type. Results: The median age was 62 years and the male to female ratio was 1.2 : 1. Significant prognostic factors for overall survival (OS) by univariate analysis were the presence of B symptoms (P = 0.018), platelet count <150 × 109/l (P = 0.065), and the International Prognostic Index (IPI; P = 0.019). However, multivariate analysis indicated that only the IPI was an independent predictor of OS. Combination chemotherapy including anthracyclines was given as the initial therapy in 109 of the 116 patients (94%) who received treatment, and the overall and complete response rates were 70% and 34%, respectively. However, there was no survival benefit for those receiving an anthracycline-containing regimen. Conclusion: Patients with aggressive ATL have a poor clinical outcome and the IPI is a useful model for predicting outcome in ATL of the lymphoma type.</description><identifier>ISSN: 0923-7534</identifier><identifier>EISSN: 1569-8041</identifier><identifier>DOI: 10.1093/annonc/mdn696</identifier><identifier>PMID: 19150954</identifier><language>eng</language><publisher>Oxford: Oxford University Press</publisher><subject>Adult ; Aged ; Aged, 80 and over ; Antineoplastic agents ; ATL ; Biological and medical sciences ; Female ; Hematologic and hematopoietic diseases ; Human viral diseases ; Humans ; Infectious diseases ; international ; leukemia ; Leukemia-Lymphoma, Adult T-Cell - pathology ; Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis ; lymphoma ; Male ; Medical sciences ; Middle Aged ; Pharmacology. Drug treatments ; Prognosis ; prognostic index ; T-cell ; Viral diseases ; Viral diseases of the lymphoid tissue and the blood. Aids</subject><ispartof>Annals of oncology, 2009-04, Vol.20 (4), p.715-721</ispartof><rights>The Author 2009. Published by Oxford University Press on behalf of the European Society for Medical Oncology. All rights reserved. For permissions, please email: journals.permissions@oxfordjournals.org 2009</rights><rights>2009 INIST-CNRS</rights><rights>The Author 2009. Published by Oxford University Press on behalf of the European Society for Medical Oncology. All rights reserved. For permissions, please email: journals.permissions@oxfordjournals.org</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c458t-c5d022405b6f0243109ee661a3ce44d0825df333c877eae42b76e18aba9c97b53</citedby><cites>FETCH-LOGICAL-c458t-c5d022405b6f0243109ee661a3ce44d0825df333c877eae42b76e18aba9c97b53</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27901,27902</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=21310235$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/19150954$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Suzumiya, J.</creatorcontrib><creatorcontrib>Ohshima, K.</creatorcontrib><creatorcontrib>Tamura, K.</creatorcontrib><creatorcontrib>Karube, K.</creatorcontrib><creatorcontrib>Uike, N.</creatorcontrib><creatorcontrib>Tobinai, K.</creatorcontrib><creatorcontrib>Gascoyne, R. D.</creatorcontrib><creatorcontrib>Vose, J. M.</creatorcontrib><creatorcontrib>Armitage, J. O.</creatorcontrib><creatorcontrib>Weisenburger, D. D.</creatorcontrib><creatorcontrib>International Peripheral T-Cell Lymphoma Project</creatorcontrib><title>The International Prognostic Index predicts outcome in aggressive adult T-cell leukemia/lymphoma: analysis of 126 patients from the International Peripheral T-cell Lymphoma Project</title><title>Annals of oncology</title><addtitle>Ann Oncol</addtitle><description>Background: The International Peripheral T-cell Lymphoma Project was organized to better understand the T-cell and natural killer (NK) cell lymphomas, and our task is to present the clinicopathologic correlations and therapeutic results for adult T-cell leukemia/lymphoma (ATL). Patients and methods: Among 1153 patients with T-cell or NK cell lymphomas, 126 patients (9.6%) with ATL were represented in this project. All were categorized as aggressive ATL, i.e. acute or lymphoma type, and 87% fell into the lymphoma type. Results: The median age was 62 years and the male to female ratio was 1.2 : 1. Significant prognostic factors for overall survival (OS) by univariate analysis were the presence of B symptoms (P = 0.018), platelet count <150 × 109/l (P = 0.065), and the International Prognostic Index (IPI; P = 0.019). However, multivariate analysis indicated that only the IPI was an independent predictor of OS. Combination chemotherapy including anthracyclines was given as the initial therapy in 109 of the 116 patients (94%) who received treatment, and the overall and complete response rates were 70% and 34%, respectively. However, there was no survival benefit for those receiving an anthracycline-containing regimen. Conclusion: Patients with aggressive ATL have a poor clinical outcome and the IPI is a useful model for predicting outcome in ATL of the lymphoma type.</description><subject>Adult</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Antineoplastic agents</subject><subject>ATL</subject><subject>Biological and medical sciences</subject><subject>Female</subject><subject>Hematologic and hematopoietic diseases</subject><subject>Human viral diseases</subject><subject>Humans</subject><subject>Infectious diseases</subject><subject>international</subject><subject>leukemia</subject><subject>Leukemia-Lymphoma, Adult T-Cell - pathology</subject><subject>Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis</subject><subject>lymphoma</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Pharmacology. Drug treatments</subject><subject>Prognosis</subject><subject>prognostic index</subject><subject>T-cell</subject><subject>Viral diseases</subject><subject>Viral diseases of the lymphoid tissue and the blood. Aids</subject><issn>0923-7534</issn><issn>1569-8041</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2009</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkV-L1DAUxYso7rj66KsEQfGlTtI0abNvsuj-YURhRxFfQia9nclsm9QklZ3v5Qc0Q8sK-uBTAvnl3HPuybLnBL8lWNClstZZvewbywV_kC0I4yKvcUkeZgssCppXjJYn2ZMQ9hhjLgrxODshgjAsWLnIfq13gK5sBG9VNM6qDn32bmtdiEanhwbu0OChMToG5MaoXQ_IWKS2Ww8hmJ-AVDN2Ea1zDV2HOhhvoTdq2R36Yed6dYZUEj0Ek763iBQcDWkQ2CTXetej-O988GbYgU_XWXQ1ax2t7UHHp9mjVnUBns3nafblw_v1-WW--nRxdf5uleuS1THXrMFFUWK24S0uSpr2BcA5UVRDWTa4LljTUkp1XVWgoCw2FQdSq40SWlQbRk-z15Pu4N2PEUKUvQlHR8qCG4PkFa6qmpUJfPkXuHdjStQFSQTnnFFGEpRPkPYuBA-tHLzplT9IguWxSzl1KacuE_9iFh03PTR_6Lm8BLyaARW06lqvrDbhnitISlzQY4w3E-fG4b8zZ48mRLi7h5W_TWFpxeTlt-_y6w2-qa-vP8oL-hvITsmH</recordid><startdate>20090401</startdate><enddate>20090401</enddate><creator>Suzumiya, J.</creator><creator>Ohshima, K.</creator><creator>Tamura, K.</creator><creator>Karube, K.</creator><creator>Uike, N.</creator><creator>Tobinai, K.</creator><creator>Gascoyne, R. D.</creator><creator>Vose, J. M.</creator><creator>Armitage, J. O.</creator><creator>Weisenburger, D. D.</creator><general>Oxford University Press</general><general>Oxford Publishing Limited (England)</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7T5</scope><scope>7TM</scope><scope>7TO</scope><scope>H94</scope><scope>K9.</scope><scope>7X8</scope></search><sort><creationdate>20090401</creationdate><title>The International Prognostic Index predicts outcome in aggressive adult T-cell leukemia/lymphoma: analysis of 126 patients from the International Peripheral T-cell Lymphoma Project</title><author>Suzumiya, J. ; Ohshima, K. ; Tamura, K. ; Karube, K. ; Uike, N. ; Tobinai, K. ; Gascoyne, R. D. ; Vose, J. M. ; Armitage, J. O. ; Weisenburger, D. D.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c458t-c5d022405b6f0243109ee661a3ce44d0825df333c877eae42b76e18aba9c97b53</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2009</creationdate><topic>Adult</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Antineoplastic agents</topic><topic>ATL</topic><topic>Biological and medical sciences</topic><topic>Female</topic><topic>Hematologic and hematopoietic diseases</topic><topic>Human viral diseases</topic><topic>Humans</topic><topic>Infectious diseases</topic><topic>international</topic><topic>leukemia</topic><topic>Leukemia-Lymphoma, Adult T-Cell - pathology</topic><topic>Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis</topic><topic>lymphoma</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Pharmacology. Drug treatments</topic><topic>Prognosis</topic><topic>prognostic index</topic><topic>T-cell</topic><topic>Viral diseases</topic><topic>Viral diseases of the lymphoid tissue and the blood. Aids</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Suzumiya, J.</creatorcontrib><creatorcontrib>Ohshima, K.</creatorcontrib><creatorcontrib>Tamura, K.</creatorcontrib><creatorcontrib>Karube, K.</creatorcontrib><creatorcontrib>Uike, N.</creatorcontrib><creatorcontrib>Tobinai, K.</creatorcontrib><creatorcontrib>Gascoyne, R. D.</creatorcontrib><creatorcontrib>Vose, J. M.</creatorcontrib><creatorcontrib>Armitage, J. O.</creatorcontrib><creatorcontrib>Weisenburger, D. D.</creatorcontrib><creatorcontrib>International Peripheral T-Cell Lymphoma Project</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Immunology Abstracts</collection><collection>Nucleic Acids Abstracts</collection><collection>Oncogenes and Growth Factors Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>MEDLINE - Academic</collection><jtitle>Annals of oncology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Suzumiya, J.</au><au>Ohshima, K.</au><au>Tamura, K.</au><au>Karube, K.</au><au>Uike, N.</au><au>Tobinai, K.</au><au>Gascoyne, R. D.</au><au>Vose, J. M.</au><au>Armitage, J. O.</au><au>Weisenburger, D. D.</au><aucorp>International Peripheral T-Cell Lymphoma Project</aucorp><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The International Prognostic Index predicts outcome in aggressive adult T-cell leukemia/lymphoma: analysis of 126 patients from the International Peripheral T-cell Lymphoma Project</atitle><jtitle>Annals of oncology</jtitle><addtitle>Ann Oncol</addtitle><date>2009-04-01</date><risdate>2009</risdate><volume>20</volume><issue>4</issue><spage>715</spage><epage>721</epage><pages>715-721</pages><issn>0923-7534</issn><eissn>1569-8041</eissn><abstract>Background: The International Peripheral T-cell Lymphoma Project was organized to better understand the T-cell and natural killer (NK) cell lymphomas, and our task is to present the clinicopathologic correlations and therapeutic results for adult T-cell leukemia/lymphoma (ATL). Patients and methods: Among 1153 patients with T-cell or NK cell lymphomas, 126 patients (9.6%) with ATL were represented in this project. All were categorized as aggressive ATL, i.e. acute or lymphoma type, and 87% fell into the lymphoma type. Results: The median age was 62 years and the male to female ratio was 1.2 : 1. Significant prognostic factors for overall survival (OS) by univariate analysis were the presence of B symptoms (P = 0.018), platelet count <150 × 109/l (P = 0.065), and the International Prognostic Index (IPI; P = 0.019). However, multivariate analysis indicated that only the IPI was an independent predictor of OS. Combination chemotherapy including anthracyclines was given as the initial therapy in 109 of the 116 patients (94%) who received treatment, and the overall and complete response rates were 70% and 34%, respectively. However, there was no survival benefit for those receiving an anthracycline-containing regimen. Conclusion: Patients with aggressive ATL have a poor clinical outcome and the IPI is a useful model for predicting outcome in ATL of the lymphoma type.</abstract><cop>Oxford</cop><pub>Oxford University Press</pub><pmid>19150954</pmid><doi>10.1093/annonc/mdn696</doi><tpages>7</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Adult Aged Aged, 80 and over Antineoplastic agents ATL Biological and medical sciences Female Hematologic and hematopoietic diseases Human viral diseases Humans Infectious diseases international leukemia Leukemia-Lymphoma, Adult T-Cell - pathology Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis lymphoma Male Medical sciences Middle Aged Pharmacology. Drug treatments Prognosis prognostic index T-cell Viral diseases Viral diseases of the lymphoid tissue and the blood. Aids |
| title | The International Prognostic Index predicts outcome in aggressive adult T-cell leukemia/lymphoma: analysis of 126 patients from the International Peripheral T-cell Lymphoma Project |
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