The Role of Inter-Alpha Inhibitor Proteins in the Diagnosis of Neonatal Sepsis
We evaluated Inter-alpha inhibitor proteins (IaIp) as a diagnostic marker in neonatal sepsis. Samples were collected from 573 neonates who were examined for suspected sepsis. IaIp level was significantly lower in the septic group (121 ± 71 mg/L) than in the non-septic group (322 ± 91 mg/L). The opti...
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| Veröffentlicht in: | The Journal of pediatrics 2009-04, Vol.154 (4), p.620-622.e1 |
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| container_end_page | 622.e1 |
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| container_issue | 4 |
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| container_title | The Journal of pediatrics |
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| creator | Chaaban, Hala, MD Singh, Kultar, MD Huang, Juliza Siryaporn, Ed Lim, Yow-Pin, MD, PhD Padbury, James F., MD |
| description | We evaluated Inter-alpha inhibitor proteins (IaIp) as a diagnostic marker in neonatal sepsis. Samples were collected from 573 neonates who were examined for suspected sepsis. IaIp level was significantly lower in the septic group (121 ± 71 mg/L) than in the non-septic group (322 ± 91 mg/L). The optimal cutoff value with the receiver operating characteristic curve was ≤177 mg/L (sensitivity, 89.5%; specificity, 99%; positive predictive value, 95%; negative predictive value, 98%) with area under the curve of 0.94. IaIp is a more reliable diagnostic marker for neonatal sepsis than other available tests. |
| doi_str_mv | 10.1016/j.jpeds.2008.10.008 |
| format | Article |
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Samples were collected from 573 neonates who were examined for suspected sepsis. IaIp level was significantly lower in the septic group (121 ± 71 mg/L) than in the non-septic group (322 ± 91 mg/L). The optimal cutoff value with the receiver operating characteristic curve was ≤177 mg/L (sensitivity, 89.5%; specificity, 99%; positive predictive value, 95%; negative predictive value, 98%) with area under the curve of 0.94. 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| source | MEDLINE; ScienceDirect Journals (5 years ago - present) |
| subjects | Alpha-Globulins - metabolism Bacterial diseases Bacterial sepsis Biological and medical sciences Biomarkers - blood Case-Control Studies Female General aspects Human bacterial diseases Humans Infant, Newborn Infectious diseases Male Medical sciences Pediatrics Reproducibility of Results Sensitivity and Specificity Sepsis - diagnosis |
| title | The Role of Inter-Alpha Inhibitor Proteins in the Diagnosis of Neonatal Sepsis |
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