Chemical form of dietary l-Carnitine affects plasma but not tissue Carnitine concentrations in male Sprague-Dawley rats
In Experiment 1, rats (n = 54) were randomly assigned to control or one of the four sources of l-Carnitine supplemented at either 100 or 200 μmol/kg/day and were allowed to acclimate for 14 days. Following a 12-h fast, plasma samples were obtained at 0, 5, 10, 15, 30, 60, 120, 240, 480 and 720 min a...
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| Veröffentlicht in: | Journal of animal physiology and animal nutrition 2009-04, Vol.93 (2), p.174-180 |
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| container_title | Journal of animal physiology and animal nutrition |
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| creator | Lambert, B.D Dobson, C.M Cherry, N.M Sanderford, M.G |
| description | In Experiment 1, rats (n = 54) were randomly assigned to control or one of the four sources of l-Carnitine supplemented at either 100 or 200 μmol/kg/day and were allowed to acclimate for 14 days. Following a 12-h fast, plasma samples were obtained at 0, 5, 10, 15, 30, 60, 120, 240, 480 and 720 min after l-Carnitine feeding and assayed for free l-Carnitine concentration. Plasma-free l-Carnitine levels were affected by time after treatment intake (p < 0.0001) and l-Carnitine source (p < 0.0001). The time x source interaction was not statistically significant (p = 0.99). In Experiment 2, rats (n = 54) were randomly assigned to control or one of the four sources of l-Carnitine at either 100 or 200 μmol/kg/day and were acclimated as in experiment 1. Rats were sacrificed 120 min after feeding. Samples of liver and skeletal muscle were obtained and assayed for free l-Carnitine concentration. Neither skeletal muscle (p = 0.44) or liver (p = 0.59) tissue concentrations of l-Carnitine were affected by any l-Carnitine source as compared with the control. We conclude that some differences exist in plasma concentrations of free l-Carnitine following ingestion of different chemical forms of l-Carnitine. It is unclear if these differences in the circulating concentration of free l-Carnitine translate into any physiological differences for the animal. In this study, chemical form of l-Carnitine had no effect on skeletal muscle or liver tissue concentrations of l-Carnitine in young male Wistar rats. |
| doi_str_mv | 10.1111/j.1439-0396.2007.00802.x |
| format | Article |
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Following a 12-h fast, plasma samples were obtained at 0, 5, 10, 15, 30, 60, 120, 240, 480 and 720 min after l-Carnitine feeding and assayed for free l-Carnitine concentration. Plasma-free l-Carnitine levels were affected by time after treatment intake (p < 0.0001) and l-Carnitine source (p < 0.0001). The time x source interaction was not statistically significant (p = 0.99). In Experiment 2, rats (n = 54) were randomly assigned to control or one of the four sources of l-Carnitine at either 100 or 200 μmol/kg/day and were acclimated as in experiment 1. Rats were sacrificed 120 min after feeding. Samples of liver and skeletal muscle were obtained and assayed for free l-Carnitine concentration. Neither skeletal muscle (p = 0.44) or liver (p = 0.59) tissue concentrations of l-Carnitine were affected by any l-Carnitine source as compared with the control. We conclude that some differences exist in plasma concentrations of free l-Carnitine following ingestion of different chemical forms of l-Carnitine. It is unclear if these differences in the circulating concentration of free l-Carnitine translate into any physiological differences for the animal. In this study, chemical form of l-Carnitine had no effect on skeletal muscle or liver tissue concentrations of l-Carnitine in young male Wistar rats.</description><identifier>ISSN: 0931-2439</identifier><identifier>EISSN: 1439-0396</identifier><identifier>DOI: 10.1111/j.1439-0396.2007.00802.x</identifier><identifier>PMID: 19320930</identifier><language>eng</language><publisher>Oxford, UK: Oxford, UK : Blackwell Publishing Ltd</publisher><subject>Acetyl- l-carnitine ; Animals ; Carnitine - blood ; Carnitine - chemistry ; Carnitine - metabolism ; Diet ; Dose-Response Relationship, Drug ; l-Carnitine (free base) ; l-Carnitine fumarate ; l-Carnitine hydrochloride ; l-Carnitine l-tartrate ; Liver - metabolism ; Male ; Muscle, Skeletal - metabolism ; Rats ; Rats, Sprague-Dawley</subject><ispartof>Journal of animal physiology and animal nutrition, 2009-04, Vol.93 (2), p.174-180</ispartof><rights>2008 The Authors. Journal compilation © 2008 Blackwell Verlag GmbH</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4282-4e7db5e85e8c92e04e3eae92f28307ee2aaf10bf9acf56c09e54d45b92e9e74e3</citedby><cites>FETCH-LOGICAL-c4282-4e7db5e85e8c92e04e3eae92f28307ee2aaf10bf9acf56c09e54d45b92e9e74e3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fj.1439-0396.2007.00802.x$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fj.1439-0396.2007.00802.x$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,777,781,1412,27905,27906,45555,45556</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/19320930$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Lambert, B.D</creatorcontrib><creatorcontrib>Dobson, C.M</creatorcontrib><creatorcontrib>Cherry, N.M</creatorcontrib><creatorcontrib>Sanderford, M.G</creatorcontrib><title>Chemical form of dietary l-Carnitine affects plasma but not tissue Carnitine concentrations in male Sprague-Dawley rats</title><title>Journal of animal physiology and animal nutrition</title><addtitle>J Anim Physiol Anim Nutr (Berl)</addtitle><description>In Experiment 1, rats (n = 54) were randomly assigned to control or one of the four sources of l-Carnitine supplemented at either 100 or 200 μmol/kg/day and were allowed to acclimate for 14 days. Following a 12-h fast, plasma samples were obtained at 0, 5, 10, 15, 30, 60, 120, 240, 480 and 720 min after l-Carnitine feeding and assayed for free l-Carnitine concentration. Plasma-free l-Carnitine levels were affected by time after treatment intake (p < 0.0001) and l-Carnitine source (p < 0.0001). The time x source interaction was not statistically significant (p = 0.99). In Experiment 2, rats (n = 54) were randomly assigned to control or one of the four sources of l-Carnitine at either 100 or 200 μmol/kg/day and were acclimated as in experiment 1. Rats were sacrificed 120 min after feeding. Samples of liver and skeletal muscle were obtained and assayed for free l-Carnitine concentration. Neither skeletal muscle (p = 0.44) or liver (p = 0.59) tissue concentrations of l-Carnitine were affected by any l-Carnitine source as compared with the control. We conclude that some differences exist in plasma concentrations of free l-Carnitine following ingestion of different chemical forms of l-Carnitine. It is unclear if these differences in the circulating concentration of free l-Carnitine translate into any physiological differences for the animal. In this study, chemical form of l-Carnitine had no effect on skeletal muscle or liver tissue concentrations of l-Carnitine in young male Wistar rats.</description><subject>Acetyl- l-carnitine</subject><subject>Animals</subject><subject>Carnitine - blood</subject><subject>Carnitine - chemistry</subject><subject>Carnitine - metabolism</subject><subject>Diet</subject><subject>Dose-Response Relationship, Drug</subject><subject>l-Carnitine (free base)</subject><subject>l-Carnitine fumarate</subject><subject>l-Carnitine hydrochloride</subject><subject>l-Carnitine l-tartrate</subject><subject>Liver - metabolism</subject><subject>Male</subject><subject>Muscle, Skeletal - metabolism</subject><subject>Rats</subject><subject>Rats, Sprague-Dawley</subject><issn>0931-2439</issn><issn>1439-0396</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2009</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkF1vFCEUhonR2LX6F5Qr72Y8wMwwk3ijq3bdNNWkVhNvCMMeKut8rMBkt_9e1tm0txISCOd5D_AQQhnkLI0325wVoslANFXOAWQOUAPPD4_I4r7wmCygESzj6eCMPAthC8BkCdVTcsYawVMRFmS__IW9M7qjdvQ9HS3dOIza39EuW2o_uOgGpNpaNDHQXadDr2k7RTqMkUYXwoT0gTPjYHCIXkc3DoG6gfa6Q3q98_p2wuyD3nd4R1M5PCdPrO4Cvjit5-Tm08dvy1V2-eXi8_LdZWYKXvOsQLlpS6zTNA1HKFCgxoZbXguQiFxry6C1jTa2rAw0WBabomwT26BM9Dl5Pffd-fHPhCGq3gWDXacHHKegKglSCl4lsJ5B48cQPFq1865PIhQDdZSuturoVh3dqqN09U-6OqToy9MdU9vj5iF4spyAtzOwd-n__91Yrb9epU2KZ3PchYiH-7j2v9PzhSzVj6sLVa9_rr6vV5V6n_hXM2_1qPStd0HdXHNgAlgFhZRc_AXShKq1</recordid><startdate>200904</startdate><enddate>200904</enddate><creator>Lambert, B.D</creator><creator>Dobson, C.M</creator><creator>Cherry, N.M</creator><creator>Sanderford, M.G</creator><general>Oxford, UK : Blackwell Publishing Ltd</general><general>Blackwell Publishing Ltd</general><scope>FBQ</scope><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>200904</creationdate><title>Chemical form of dietary l-Carnitine affects plasma but not tissue Carnitine concentrations in male Sprague-Dawley rats</title><author>Lambert, B.D ; Dobson, C.M ; Cherry, N.M ; Sanderford, M.G</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4282-4e7db5e85e8c92e04e3eae92f28307ee2aaf10bf9acf56c09e54d45b92e9e74e3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2009</creationdate><topic>Acetyl- l-carnitine</topic><topic>Animals</topic><topic>Carnitine - blood</topic><topic>Carnitine - chemistry</topic><topic>Carnitine - metabolism</topic><topic>Diet</topic><topic>Dose-Response Relationship, Drug</topic><topic>l-Carnitine (free base)</topic><topic>l-Carnitine fumarate</topic><topic>l-Carnitine hydrochloride</topic><topic>l-Carnitine l-tartrate</topic><topic>Liver - metabolism</topic><topic>Male</topic><topic>Muscle, Skeletal - metabolism</topic><topic>Rats</topic><topic>Rats, Sprague-Dawley</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Lambert, B.D</creatorcontrib><creatorcontrib>Dobson, C.M</creatorcontrib><creatorcontrib>Cherry, N.M</creatorcontrib><creatorcontrib>Sanderford, M.G</creatorcontrib><collection>AGRIS</collection><collection>Istex</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of animal physiology and animal nutrition</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Lambert, B.D</au><au>Dobson, C.M</au><au>Cherry, N.M</au><au>Sanderford, M.G</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Chemical form of dietary l-Carnitine affects plasma but not tissue Carnitine concentrations in male Sprague-Dawley rats</atitle><jtitle>Journal of animal physiology and animal nutrition</jtitle><addtitle>J Anim Physiol Anim Nutr (Berl)</addtitle><date>2009-04</date><risdate>2009</risdate><volume>93</volume><issue>2</issue><spage>174</spage><epage>180</epage><pages>174-180</pages><issn>0931-2439</issn><eissn>1439-0396</eissn><abstract>In Experiment 1, rats (n = 54) were randomly assigned to control or one of the four sources of l-Carnitine supplemented at either 100 or 200 μmol/kg/day and were allowed to acclimate for 14 days. Following a 12-h fast, plasma samples were obtained at 0, 5, 10, 15, 30, 60, 120, 240, 480 and 720 min after l-Carnitine feeding and assayed for free l-Carnitine concentration. Plasma-free l-Carnitine levels were affected by time after treatment intake (p < 0.0001) and l-Carnitine source (p < 0.0001). The time x source interaction was not statistically significant (p = 0.99). In Experiment 2, rats (n = 54) were randomly assigned to control or one of the four sources of l-Carnitine at either 100 or 200 μmol/kg/day and were acclimated as in experiment 1. Rats were sacrificed 120 min after feeding. Samples of liver and skeletal muscle were obtained and assayed for free l-Carnitine concentration. Neither skeletal muscle (p = 0.44) or liver (p = 0.59) tissue concentrations of l-Carnitine were affected by any l-Carnitine source as compared with the control. We conclude that some differences exist in plasma concentrations of free l-Carnitine following ingestion of different chemical forms of l-Carnitine. It is unclear if these differences in the circulating concentration of free l-Carnitine translate into any physiological differences for the animal. In this study, chemical form of l-Carnitine had no effect on skeletal muscle or liver tissue concentrations of l-Carnitine in young male Wistar rats.</abstract><cop>Oxford, UK</cop><pub>Oxford, UK : Blackwell Publishing Ltd</pub><pmid>19320930</pmid><doi>10.1111/j.1439-0396.2007.00802.x</doi><tpages>7</tpages></addata></record> |
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| source | MEDLINE; Wiley Online Library Journals Frontfile Complete |
| subjects | Acetyl- l-carnitine Animals Carnitine - blood Carnitine - chemistry Carnitine - metabolism Diet Dose-Response Relationship, Drug l-Carnitine (free base) l-Carnitine fumarate l-Carnitine hydrochloride l-Carnitine l-tartrate Liver - metabolism Male Muscle, Skeletal - metabolism Rats Rats, Sprague-Dawley |
| title | Chemical form of dietary l-Carnitine affects plasma but not tissue Carnitine concentrations in male Sprague-Dawley rats |
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