Enhancement of the efficacy of an antagonist of an extracellular receptor by attachment to the surface of a biocompatible carrier

In order to improve the in vitro and in vivo efficacy of an integrin antagonist (IA) of the extracellular domain of the alphavbeta3 integrin, a receptor upregulated on tumor neovasculature, the IA was attached to the surface of a dextran-coated liposome (DCL). IA-DCLs were characterized in vitro, an...

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Veröffentlicht in:	Pharmaceutical research 2004-10, Vol.21 (10), p.1880-1885
Hauptverfasser:	Wartchow, Charles A, Alters, Susan E, Garzone, Pamela D, Li, Lingyun, Choi, Steven, DeChene, Neal E, Doede, Tina, Huang, Linong, Pease, John S, Shen, Zhimin, Knox, Susan J, Cleland, Jeffrey L
Format:	Artikel
Sprache:	eng
Schlagworte:	Angiogenesis Angiogenesis Inhibitors - administration & dosage Angiogenesis Inhibitors - pharmacology Animals Antineoplastic Agents - administration & dosage Antineoplastic Agents - pharmacokinetics Antineoplastic Agents - pharmacology Apoptosis Biocompatibility Biocompatible Materials Cell Adhesion - drug effects Cell growth Cell Proliferation - drug effects Cholesterol Dextrans Drug Carriers Drug Compounding Drug Delivery Systems Endothelial Cells - drug effects Half-Life Humans In Situ Nick-End Labeling Integrin alphaVbeta3 - antagonists & inhibitors Liposomes Melanoma Melanoma - drug therapy Melanoma - pathology Mice Neoplasm Transplantation Neoplasms, Experimental - drug therapy Peptides Pharmacokinetics Polyethylene glycol Tissue Distribution
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