Collagen antibody-induced arthritis in mice: Development of a new arthritogenic 5-clone cocktail of monoclonal anti-type II collagen antibodies
A cocktail of 4 monoclonal anti-type II collagen antibodies recognizing conserved epitopes located within the CB11 fragment (CII 124-402) of type II collagen is currently used as an arthritogenic antibody preparation for inducing collagen antibody induced arthritis (CAIA). In order to increase the a...
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| Veröffentlicht in: | Journal of immunological methods 2009-03, Vol.343 (1), p.49-55 |
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| creator | Hutamekalin, Pilaiwanwadee Saito, Takayuki Yamaki, Kouya Mizutani, Nobuaki Brand, David D. Waritani, Takaki Terato, Kuniaki Yoshino, Shin |
| description | A cocktail of 4 monoclonal anti-type II collagen antibodies recognizing conserved epitopes located within the CB11 fragment (CII 124-402) of type II collagen is currently used as an arthritogenic antibody preparation for inducing collagen antibody induced arthritis (CAIA). In order to increase the arthritogenicity of this cocktail, we have developed 7 new monoclonal antibodies to anti-type II collagen from spleen cells of DBA/1J mice immunized with bovine type II collagen, and tested for their additional effect on the arthritogenicity over that of the current 4-clone cocktail. Three of the clones (CII-3, -5 and -6) bind to the LyC1 (CII 124-290) peptide of CB11 and 1 (CII-7) of the clones binds to CB9.7 (CII 898-1020), and highly cross-reacted with other species of type II collagen. This indicates that these clones recognize conserved epitopes within type II collagen, including mouse type II collagen. On the other hand, 2 other clones (CII-1 and -4) directed against CB9.7 and 1 clone (CII-2) against CB8 (CII 403-551) were less reactive with other species of type II collagen.
The arthritogenicity of the current 4-clone cocktail was significantly increased by addition of a fifth clone, CII-3. No effects were observed with other clones. The arthritogenicity of this new 5-clone cocktail was 2-fold greater than the current 4-clone cocktail in all strains of mice tested: the CIA-responder strain DBA/1J, the CIA-resistant BALB/c (H-2
d), the T-cell deficient C.B-17/l scid/scid and the CAIA-low responder C57BL/6 (H-2
b) strain. These results clearly indicated the importance of epitope specificity of arthritogenicity of autoantibodies to type II collagen. Due to its enhanced arthritogenicity, this 5-clone cocktail is capable of inducing a more consistent and severe arthritis with lower doses compared to the current 4-clone cocktail, and will provide an effective new reagent for inducing arthritis in various strains of CAIA low responder mice. |
| doi_str_mv | 10.1016/j.jim.2009.01.009 |
| format | Article |
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The arthritogenicity of the current 4-clone cocktail was significantly increased by addition of a fifth clone, CII-3. No effects were observed with other clones. The arthritogenicity of this new 5-clone cocktail was 2-fold greater than the current 4-clone cocktail in all strains of mice tested: the CIA-responder strain DBA/1J, the CIA-resistant BALB/c (H-2
d), the T-cell deficient C.B-17/l scid/scid and the CAIA-low responder C57BL/6 (H-2
b) strain. These results clearly indicated the importance of epitope specificity of arthritogenicity of autoantibodies to type II collagen. Due to its enhanced arthritogenicity, this 5-clone cocktail is capable of inducing a more consistent and severe arthritis with lower doses compared to the current 4-clone cocktail, and will provide an effective new reagent for inducing arthritis in various strains of CAIA low responder mice.</description><identifier>ISSN: 0022-1759</identifier><identifier>EISSN: 1872-7905</identifier><identifier>DOI: 10.1016/j.jim.2009.01.009</identifier><identifier>PMID: 19330909</identifier><identifier>CODEN: JIMMBG</identifier><language>eng</language><publisher>Amsterdam: Elsevier B.V</publisher><subject>Animals ; Antibodies, Anti-Idiotypic - immunology ; Antibodies, Monoclonal - administration & dosage ; Antibodies, Monoclonal - immunology ; Arthritis, Experimental - immunology ; Arthritogenic epitope ; Arthritogenicity ; Biological and medical sciences ; CAIA ; Cattle ; CIA ; Collagen Type II - immunology ; Disease Models, Animal ; Epitopes - analysis ; Epitopes - immunology ; Fundamental and applied biological sciences. Psychology ; Fundamental immunology ; Hybridomas - immunology ; Male ; Mice ; Mice, Inbred BALB C ; Mice, Inbred C57BL ; Mice, Inbred DBA ; Molecular immunology ; Monoclonal antibody ; Rheumatoid arthritis ; Species Specificity ; Techniques</subject><ispartof>Journal of immunological methods, 2009-03, Vol.343 (1), p.49-55</ispartof><rights>2009 Elsevier B.V.</rights><rights>2009 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c478t-7047126d95caff14ab2d5b3d3f947b319a1dc45cf3250218753cf5c9c9c54f2e3</citedby><cites>FETCH-LOGICAL-c478t-7047126d95caff14ab2d5b3d3f947b319a1dc45cf3250218753cf5c9c9c54f2e3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.jim.2009.01.009$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3550,27924,27925,45995</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=21270446$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/19330909$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Hutamekalin, Pilaiwanwadee</creatorcontrib><creatorcontrib>Saito, Takayuki</creatorcontrib><creatorcontrib>Yamaki, Kouya</creatorcontrib><creatorcontrib>Mizutani, Nobuaki</creatorcontrib><creatorcontrib>Brand, David D.</creatorcontrib><creatorcontrib>Waritani, Takaki</creatorcontrib><creatorcontrib>Terato, Kuniaki</creatorcontrib><creatorcontrib>Yoshino, Shin</creatorcontrib><title>Collagen antibody-induced arthritis in mice: Development of a new arthritogenic 5-clone cocktail of monoclonal anti-type II collagen antibodies</title><title>Journal of immunological methods</title><addtitle>J Immunol Methods</addtitle><description>A cocktail of 4 monoclonal anti-type II collagen antibodies recognizing conserved epitopes located within the CB11 fragment (CII 124-402) of type II collagen is currently used as an arthritogenic antibody preparation for inducing collagen antibody induced arthritis (CAIA). In order to increase the arthritogenicity of this cocktail, we have developed 7 new monoclonal antibodies to anti-type II collagen from spleen cells of DBA/1J mice immunized with bovine type II collagen, and tested for their additional effect on the arthritogenicity over that of the current 4-clone cocktail. Three of the clones (CII-3, -5 and -6) bind to the LyC1 (CII 124-290) peptide of CB11 and 1 (CII-7) of the clones binds to CB9.7 (CII 898-1020), and highly cross-reacted with other species of type II collagen. This indicates that these clones recognize conserved epitopes within type II collagen, including mouse type II collagen. On the other hand, 2 other clones (CII-1 and -4) directed against CB9.7 and 1 clone (CII-2) against CB8 (CII 403-551) were less reactive with other species of type II collagen.
The arthritogenicity of the current 4-clone cocktail was significantly increased by addition of a fifth clone, CII-3. No effects were observed with other clones. The arthritogenicity of this new 5-clone cocktail was 2-fold greater than the current 4-clone cocktail in all strains of mice tested: the CIA-responder strain DBA/1J, the CIA-resistant BALB/c (H-2
d), the T-cell deficient C.B-17/l scid/scid and the CAIA-low responder C57BL/6 (H-2
b) strain. These results clearly indicated the importance of epitope specificity of arthritogenicity of autoantibodies to type II collagen. Due to its enhanced arthritogenicity, this 5-clone cocktail is capable of inducing a more consistent and severe arthritis with lower doses compared to the current 4-clone cocktail, and will provide an effective new reagent for inducing arthritis in various strains of CAIA low responder mice.</description><subject>Animals</subject><subject>Antibodies, Anti-Idiotypic - immunology</subject><subject>Antibodies, Monoclonal - administration & dosage</subject><subject>Antibodies, Monoclonal - immunology</subject><subject>Arthritis, Experimental - immunology</subject><subject>Arthritogenic epitope</subject><subject>Arthritogenicity</subject><subject>Biological and medical sciences</subject><subject>CAIA</subject><subject>Cattle</subject><subject>CIA</subject><subject>Collagen Type II - immunology</subject><subject>Disease Models, Animal</subject><subject>Epitopes - analysis</subject><subject>Epitopes - immunology</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Fundamental immunology</subject><subject>Hybridomas - immunology</subject><subject>Male</subject><subject>Mice</subject><subject>Mice, Inbred BALB C</subject><subject>Mice, Inbred C57BL</subject><subject>Mice, Inbred DBA</subject><subject>Molecular immunology</subject><subject>Monoclonal antibody</subject><subject>Rheumatoid arthritis</subject><subject>Species Specificity</subject><subject>Techniques</subject><issn>0022-1759</issn><issn>1872-7905</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2009</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkUGP0zAQhSMEYrsLP4AL8gVuCWM7jms4rcoClVbiAmfLccbgktjFThf1V_CXcWgBcQH58CTrmzej96rqCYWGAu1e7JqdnxoGoBqgTZF71YquJaulAnG_WgEwVlMp1EV1mfMOACh08LC6oIpzUKBW1fdNHEfzCQMxYfZ9HI61D8PB4kBMmj8nP_tMfCCTt_iSvMY7HON-wjCT6IghAb_94mIx8ZaI2o4xILHRfpmNHxduiiEuv2b8uaWej3sk221h_t7tMT-qHjgzZnx81qvq45ubD5t39e37t9vN9W1tW7meawmtpKwblLDGOdqang2i5wN3qpU9p8rQwbbCOs4EsJKJ4NYJq8oTrWPIr6rnJ999il8PmGc9-Wyx3BMwHrLuJEixFuy_IAMuO8W7AtITaFPMOaHT--Qnk46agl7q0jtd6tJLXRqoLlJmnp7ND_2Ew5-Jcz8FeHYGTLZmdMkE6_NvjlFWkmiX5a9OHJbM7jwmna3HUGr0Ce2sh-j_ccYPbpW0UA</recordid><startdate>20090331</startdate><enddate>20090331</enddate><creator>Hutamekalin, Pilaiwanwadee</creator><creator>Saito, Takayuki</creator><creator>Yamaki, Kouya</creator><creator>Mizutani, Nobuaki</creator><creator>Brand, David D.</creator><creator>Waritani, Takaki</creator><creator>Terato, Kuniaki</creator><creator>Yoshino, Shin</creator><general>Elsevier B.V</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QO</scope><scope>7T5</scope><scope>8FD</scope><scope>F1W</scope><scope>FR3</scope><scope>H94</scope><scope>H99</scope><scope>L.F</scope><scope>L.G</scope><scope>P64</scope><scope>7X8</scope></search><sort><creationdate>20090331</creationdate><title>Collagen antibody-induced arthritis in mice: Development of a new arthritogenic 5-clone cocktail of monoclonal anti-type II collagen antibodies</title><author>Hutamekalin, Pilaiwanwadee ; Saito, Takayuki ; Yamaki, Kouya ; Mizutani, Nobuaki ; Brand, David D. ; Waritani, Takaki ; Terato, Kuniaki ; Yoshino, Shin</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c478t-7047126d95caff14ab2d5b3d3f947b319a1dc45cf3250218753cf5c9c9c54f2e3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2009</creationdate><topic>Animals</topic><topic>Antibodies, Anti-Idiotypic - immunology</topic><topic>Antibodies, Monoclonal - administration & dosage</topic><topic>Antibodies, Monoclonal - immunology</topic><topic>Arthritis, Experimental - immunology</topic><topic>Arthritogenic epitope</topic><topic>Arthritogenicity</topic><topic>Biological and medical sciences</topic><topic>CAIA</topic><topic>Cattle</topic><topic>CIA</topic><topic>Collagen Type II - immunology</topic><topic>Disease Models, Animal</topic><topic>Epitopes - analysis</topic><topic>Epitopes - immunology</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Fundamental immunology</topic><topic>Hybridomas - immunology</topic><topic>Male</topic><topic>Mice</topic><topic>Mice, Inbred BALB C</topic><topic>Mice, Inbred C57BL</topic><topic>Mice, Inbred DBA</topic><topic>Molecular immunology</topic><topic>Monoclonal antibody</topic><topic>Rheumatoid arthritis</topic><topic>Species Specificity</topic><topic>Techniques</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Hutamekalin, Pilaiwanwadee</creatorcontrib><creatorcontrib>Saito, Takayuki</creatorcontrib><creatorcontrib>Yamaki, Kouya</creatorcontrib><creatorcontrib>Mizutani, Nobuaki</creatorcontrib><creatorcontrib>Brand, David D.</creatorcontrib><creatorcontrib>Waritani, Takaki</creatorcontrib><creatorcontrib>Terato, Kuniaki</creatorcontrib><creatorcontrib>Yoshino, Shin</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Biotechnology Research Abstracts</collection><collection>Immunology Abstracts</collection><collection>Technology Research Database</collection><collection>ASFA: Aquatic Sciences and Fisheries Abstracts</collection><collection>Engineering Research Database</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ASFA: Marine Biotechnology Abstracts</collection><collection>Aquatic Science & Fisheries Abstracts (ASFA) Marine Biotechnology Abstracts</collection><collection>Aquatic Science & Fisheries Abstracts (ASFA) Professional</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of immunological methods</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Hutamekalin, Pilaiwanwadee</au><au>Saito, Takayuki</au><au>Yamaki, Kouya</au><au>Mizutani, Nobuaki</au><au>Brand, David D.</au><au>Waritani, Takaki</au><au>Terato, Kuniaki</au><au>Yoshino, Shin</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Collagen antibody-induced arthritis in mice: Development of a new arthritogenic 5-clone cocktail of monoclonal anti-type II collagen antibodies</atitle><jtitle>Journal of immunological methods</jtitle><addtitle>J Immunol Methods</addtitle><date>2009-03-31</date><risdate>2009</risdate><volume>343</volume><issue>1</issue><spage>49</spage><epage>55</epage><pages>49-55</pages><issn>0022-1759</issn><eissn>1872-7905</eissn><coden>JIMMBG</coden><abstract>A cocktail of 4 monoclonal anti-type II collagen antibodies recognizing conserved epitopes located within the CB11 fragment (CII 124-402) of type II collagen is currently used as an arthritogenic antibody preparation for inducing collagen antibody induced arthritis (CAIA). In order to increase the arthritogenicity of this cocktail, we have developed 7 new monoclonal antibodies to anti-type II collagen from spleen cells of DBA/1J mice immunized with bovine type II collagen, and tested for their additional effect on the arthritogenicity over that of the current 4-clone cocktail. Three of the clones (CII-3, -5 and -6) bind to the LyC1 (CII 124-290) peptide of CB11 and 1 (CII-7) of the clones binds to CB9.7 (CII 898-1020), and highly cross-reacted with other species of type II collagen. This indicates that these clones recognize conserved epitopes within type II collagen, including mouse type II collagen. On the other hand, 2 other clones (CII-1 and -4) directed against CB9.7 and 1 clone (CII-2) against CB8 (CII 403-551) were less reactive with other species of type II collagen.
The arthritogenicity of the current 4-clone cocktail was significantly increased by addition of a fifth clone, CII-3. No effects were observed with other clones. The arthritogenicity of this new 5-clone cocktail was 2-fold greater than the current 4-clone cocktail in all strains of mice tested: the CIA-responder strain DBA/1J, the CIA-resistant BALB/c (H-2
d), the T-cell deficient C.B-17/l scid/scid and the CAIA-low responder C57BL/6 (H-2
b) strain. These results clearly indicated the importance of epitope specificity of arthritogenicity of autoantibodies to type II collagen. Due to its enhanced arthritogenicity, this 5-clone cocktail is capable of inducing a more consistent and severe arthritis with lower doses compared to the current 4-clone cocktail, and will provide an effective new reagent for inducing arthritis in various strains of CAIA low responder mice.</abstract><cop>Amsterdam</cop><pub>Elsevier B.V</pub><pmid>19330909</pmid><doi>10.1016/j.jim.2009.01.009</doi><tpages>7</tpages></addata></record> |
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| subjects | Animals Antibodies, Anti-Idiotypic - immunology Antibodies, Monoclonal - administration & dosage Antibodies, Monoclonal - immunology Arthritis, Experimental - immunology Arthritogenic epitope Arthritogenicity Biological and medical sciences CAIA Cattle CIA Collagen Type II - immunology Disease Models, Animal Epitopes - analysis Epitopes - immunology Fundamental and applied biological sciences. Psychology Fundamental immunology Hybridomas - immunology Male Mice Mice, Inbred BALB C Mice, Inbred C57BL Mice, Inbred DBA Molecular immunology Monoclonal antibody Rheumatoid arthritis Species Specificity Techniques |
| title | Collagen antibody-induced arthritis in mice: Development of a new arthritogenic 5-clone cocktail of monoclonal anti-type II collagen antibodies |
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