Sex-Modified Effect of Hepatitis B Virus Infection on Mortality From Primary Liver Cancer
Sex and hepatitis B virus (HBV) infection are both important risk factors for primary liver cancer. However, their possible biologic interaction has not been well studied. The authors examined data from 89,789 subjects aged 25–69 years who participated in a 14-year cohort study (1992–2006) conducted...
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| Veröffentlicht in: | American journal of epidemiology 2009-04, Vol.169 (8), p.990-995 |
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| creator | Wang, Na Zheng, Yingjie Yu, Xinsen Lin, Wenyao Chen, Yue Jiang, Qingwu |
| description | Sex and hepatitis B virus (HBV) infection are both important risk factors for primary liver cancer. However, their possible biologic interaction has not been well studied. The authors examined data from 89,789 subjects aged 25–69 years who participated in a 14-year cohort study (1992–2006) conducted in Haimen, China. An age-stratified Cox proportional hazards model was used for multivariate analysis. The authors assessed the combined effect of sex and HBV infection on liver cancer mortality by calculating 3 interaction measures: the relative risk due to interaction, the attributable proportion of interaction, and the synergy index. There was a greater risk difference between hepatitis B surface antigen carriers and noncarriers among men than among women. After adjustment for potential confounders, the relative risk due to interaction, the attributable proportion of interaction, and the synergy index were 33.27 (95% confidence interval (CI): 22.54, 43.99), 0.59 (95% CI: 0.55, 0.63), and 2.49 (95% CI: 2.13, 2.90), respectively, suggesting a significant synergistic effect of the interaction between sex and HBV infection on liver cancer mortality. HBV infection had a larger impact on liver cancer mortality in men than in women, which may explain at least part of the sex difference in liver cancer risk. |
| doi_str_mv | 10.1093/aje/kwn418 |
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However, their possible biologic interaction has not been well studied. The authors examined data from 89,789 subjects aged 25–69 years who participated in a 14-year cohort study (1992–2006) conducted in Haimen, China. An age-stratified Cox proportional hazards model was used for multivariate analysis. The authors assessed the combined effect of sex and HBV infection on liver cancer mortality by calculating 3 interaction measures: the relative risk due to interaction, the attributable proportion of interaction, and the synergy index. There was a greater risk difference between hepatitis B surface antigen carriers and noncarriers among men than among women. After adjustment for potential confounders, the relative risk due to interaction, the attributable proportion of interaction, and the synergy index were 33.27 (95% confidence interval (CI): 22.54, 43.99), 0.59 (95% CI: 0.55, 0.63), and 2.49 (95% CI: 2.13, 2.90), respectively, suggesting a significant synergistic effect of the interaction between sex and HBV infection on liver cancer mortality. HBV infection had a larger impact on liver cancer mortality in men than in women, which may explain at least part of the sex difference in liver cancer risk.</description><identifier>ISSN: 0002-9262</identifier><identifier>EISSN: 1476-6256</identifier><identifier>DOI: 10.1093/aje/kwn418</identifier><identifier>PMID: 19224979</identifier><identifier>CODEN: AJEPAS</identifier><language>eng</language><publisher>Cary, NC: Oxford University Press</publisher><subject>Adult ; Age Factors ; Aged ; Alcohol Drinking - epidemiology ; Analysis. Health state ; Biological and medical sciences ; Cancer ; Carcinoma, Hepatocellular - mortality ; Carrier State - epidemiology ; China ; China - epidemiology ; cohort studies ; Comorbidity ; Epidemiology ; Female ; Gastroenterology. Liver. Pancreas. Abdomen ; Gender differences ; General aspects ; Hepatitis ; Hepatitis B - epidemiology ; Hepatitis B virus ; Human viral diseases ; Humans ; Infectious diseases ; Liver diseases ; liver neoplasms ; Liver Neoplasms - mortality ; Liver. Biliary tract. Portal circulation. Exocrine pancreas ; Longitudinal Studies ; Male ; Medical sciences ; Middle Aged ; Miscellaneous ; Mortality ; Public health. Hygiene ; Public health. Hygiene-occupational medicine ; Risk Assessment ; Risk factors ; sex ; Sex Distribution ; Sex Factors ; Smoking - epidemiology ; Tumors ; Viral diseases ; Viral hepatitis</subject><ispartof>American journal of epidemiology, 2009-04, Vol.169 (8), p.990-995</ispartof><rights>American Journal of Epidemiology © The Author 2009. Published by the Johns Hopkins Bloomberg School of Public Health. All rights reserved. For permissions, please e-mail: journals.permissions@oxfordjournals.org. 2009</rights><rights>2009 INIST-CNRS</rights><rights>American Journal of Epidemiology © The Author 2009. Published by the Johns Hopkins Bloomberg School of Public Health. All rights reserved. For permissions, please e-mail: journals.permissions@oxfordjournals.org.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c543t-4f3b0e87677516c000985ed274ea1f50975b13514348d883dc2d842d357cf9e73</citedby><cites>FETCH-LOGICAL-c543t-4f3b0e87677516c000985ed274ea1f50975b13514348d883dc2d842d357cf9e73</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,1578,27903,27904</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=21399804$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/19224979$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Wang, Na</creatorcontrib><creatorcontrib>Zheng, Yingjie</creatorcontrib><creatorcontrib>Yu, Xinsen</creatorcontrib><creatorcontrib>Lin, Wenyao</creatorcontrib><creatorcontrib>Chen, Yue</creatorcontrib><creatorcontrib>Jiang, Qingwu</creatorcontrib><title>Sex-Modified Effect of Hepatitis B Virus Infection on Mortality From Primary Liver Cancer</title><title>American journal of epidemiology</title><addtitle>Am J Epidemiol</addtitle><description>Sex and hepatitis B virus (HBV) infection are both important risk factors for primary liver cancer. However, their possible biologic interaction has not been well studied. The authors examined data from 89,789 subjects aged 25–69 years who participated in a 14-year cohort study (1992–2006) conducted in Haimen, China. An age-stratified Cox proportional hazards model was used for multivariate analysis. The authors assessed the combined effect of sex and HBV infection on liver cancer mortality by calculating 3 interaction measures: the relative risk due to interaction, the attributable proportion of interaction, and the synergy index. There was a greater risk difference between hepatitis B surface antigen carriers and noncarriers among men than among women. After adjustment for potential confounders, the relative risk due to interaction, the attributable proportion of interaction, and the synergy index were 33.27 (95% confidence interval (CI): 22.54, 43.99), 0.59 (95% CI: 0.55, 0.63), and 2.49 (95% CI: 2.13, 2.90), respectively, suggesting a significant synergistic effect of the interaction between sex and HBV infection on liver cancer mortality. HBV infection had a larger impact on liver cancer mortality in men than in women, which may explain at least part of the sex difference in liver cancer risk.</description><subject>Adult</subject><subject>Age Factors</subject><subject>Aged</subject><subject>Alcohol Drinking - epidemiology</subject><subject>Analysis. Health state</subject><subject>Biological and medical sciences</subject><subject>Cancer</subject><subject>Carcinoma, Hepatocellular - mortality</subject><subject>Carrier State - epidemiology</subject><subject>China</subject><subject>China - epidemiology</subject><subject>cohort studies</subject><subject>Comorbidity</subject><subject>Epidemiology</subject><subject>Female</subject><subject>Gastroenterology. Liver. Pancreas. Abdomen</subject><subject>Gender differences</subject><subject>General aspects</subject><subject>Hepatitis</subject><subject>Hepatitis B - epidemiology</subject><subject>Hepatitis B virus</subject><subject>Human viral diseases</subject><subject>Humans</subject><subject>Infectious diseases</subject><subject>Liver diseases</subject><subject>liver neoplasms</subject><subject>Liver Neoplasms - mortality</subject><subject>Liver. Biliary tract. Portal circulation. Exocrine pancreas</subject><subject>Longitudinal Studies</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Miscellaneous</subject><subject>Mortality</subject><subject>Public health. Hygiene</subject><subject>Public health. Hygiene-occupational medicine</subject><subject>Risk Assessment</subject><subject>Risk factors</subject><subject>sex</subject><subject>Sex Distribution</subject><subject>Sex Factors</subject><subject>Smoking - epidemiology</subject><subject>Tumors</subject><subject>Viral diseases</subject><subject>Viral hepatitis</subject><issn>0002-9262</issn><issn>1476-6256</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2009</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqF0U1rFDEcBvAgit1WL34ACUI9CGPz_nLUtXULWxRfinoJ2UwC2c5OtslMbb-9KbO04KGFQA758ST5PwC8wug9Rpoe2bU_uvjbM6yegBlmUjSCcPEUzBBCpNFEkD2wX8oaIYw1R8_BHtaEMC31DPz-7q-bs9TGEH0Lj0PwboApwIXf2iEOscCP8DzmscDT_vYsph7WdZbyYLs43MCTnDbwa44bm2_gMl75DOe2dz6_AM-C7Yp_udsPwM-T4x_zRbP88vl0_mHZOM7o0LBAV8grKaTkWLj6ZK24b4lk3uLAkZZ8hSnHjDLVKkVbR1rFSEu5dEF7SQ_A2yl3m9Pl6MtgNrE433W292ksRkgkec1-FBLEEWaaVPjmP7hOY-7rJwyhXHFFqajo3YRcTqVkH8x2GoLByNzWYmotZqql4te7xHG18e093fVQweEO2OJsF3IdYSx3jmCqtULs3qVx-_CFzeRiGfz1nbT5os6DSm4Wv_4YPf-mBT1fmE_0H9Akrwc</recordid><startdate>20090415</startdate><enddate>20090415</enddate><creator>Wang, Na</creator><creator>Zheng, Yingjie</creator><creator>Yu, Xinsen</creator><creator>Lin, Wenyao</creator><creator>Chen, Yue</creator><creator>Jiang, Qingwu</creator><general>Oxford University Press</general><general>Oxford Publishing Limited (England)</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QP</scope><scope>7T2</scope><scope>7TK</scope><scope>7U7</scope><scope>7U9</scope><scope>C1K</scope><scope>H94</scope><scope>K9.</scope><scope>NAPCQ</scope><scope>7X8</scope></search><sort><creationdate>20090415</creationdate><title>Sex-Modified Effect of Hepatitis B Virus Infection on Mortality From Primary Liver Cancer</title><author>Wang, Na ; Zheng, Yingjie ; Yu, Xinsen ; Lin, Wenyao ; Chen, Yue ; Jiang, Qingwu</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c543t-4f3b0e87677516c000985ed274ea1f50975b13514348d883dc2d842d357cf9e73</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2009</creationdate><topic>Adult</topic><topic>Age Factors</topic><topic>Aged</topic><topic>Alcohol Drinking - epidemiology</topic><topic>Analysis. Health state</topic><topic>Biological and medical sciences</topic><topic>Cancer</topic><topic>Carcinoma, Hepatocellular - mortality</topic><topic>Carrier State - epidemiology</topic><topic>China</topic><topic>China - epidemiology</topic><topic>cohort studies</topic><topic>Comorbidity</topic><topic>Epidemiology</topic><topic>Female</topic><topic>Gastroenterology. Liver. Pancreas. Abdomen</topic><topic>Gender differences</topic><topic>General aspects</topic><topic>Hepatitis</topic><topic>Hepatitis B - epidemiology</topic><topic>Hepatitis B virus</topic><topic>Human viral diseases</topic><topic>Humans</topic><topic>Infectious diseases</topic><topic>Liver diseases</topic><topic>liver neoplasms</topic><topic>Liver Neoplasms - mortality</topic><topic>Liver. Biliary tract. Portal circulation. Exocrine pancreas</topic><topic>Longitudinal Studies</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Miscellaneous</topic><topic>Mortality</topic><topic>Public health. Hygiene</topic><topic>Public health. Hygiene-occupational medicine</topic><topic>Risk Assessment</topic><topic>Risk factors</topic><topic>sex</topic><topic>Sex Distribution</topic><topic>Sex Factors</topic><topic>Smoking - epidemiology</topic><topic>Tumors</topic><topic>Viral diseases</topic><topic>Viral hepatitis</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Wang, Na</creatorcontrib><creatorcontrib>Zheng, Yingjie</creatorcontrib><creatorcontrib>Yu, Xinsen</creatorcontrib><creatorcontrib>Lin, Wenyao</creatorcontrib><creatorcontrib>Chen, Yue</creatorcontrib><creatorcontrib>Jiang, Qingwu</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Health and Safety Science Abstracts (Full archive)</collection><collection>Neurosciences Abstracts</collection><collection>Toxicology Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Environmental Sciences and Pollution Management</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Premium</collection><collection>MEDLINE - Academic</collection><jtitle>American journal of epidemiology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Wang, Na</au><au>Zheng, Yingjie</au><au>Yu, Xinsen</au><au>Lin, Wenyao</au><au>Chen, Yue</au><au>Jiang, Qingwu</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Sex-Modified Effect of Hepatitis B Virus Infection on Mortality From Primary Liver Cancer</atitle><jtitle>American journal of epidemiology</jtitle><addtitle>Am J Epidemiol</addtitle><date>2009-04-15</date><risdate>2009</risdate><volume>169</volume><issue>8</issue><spage>990</spage><epage>995</epage><pages>990-995</pages><issn>0002-9262</issn><eissn>1476-6256</eissn><coden>AJEPAS</coden><abstract>Sex and hepatitis B virus (HBV) infection are both important risk factors for primary liver cancer. However, their possible biologic interaction has not been well studied. The authors examined data from 89,789 subjects aged 25–69 years who participated in a 14-year cohort study (1992–2006) conducted in Haimen, China. An age-stratified Cox proportional hazards model was used for multivariate analysis. The authors assessed the combined effect of sex and HBV infection on liver cancer mortality by calculating 3 interaction measures: the relative risk due to interaction, the attributable proportion of interaction, and the synergy index. There was a greater risk difference between hepatitis B surface antigen carriers and noncarriers among men than among women. After adjustment for potential confounders, the relative risk due to interaction, the attributable proportion of interaction, and the synergy index were 33.27 (95% confidence interval (CI): 22.54, 43.99), 0.59 (95% CI: 0.55, 0.63), and 2.49 (95% CI: 2.13, 2.90), respectively, suggesting a significant synergistic effect of the interaction between sex and HBV infection on liver cancer mortality. HBV infection had a larger impact on liver cancer mortality in men than in women, which may explain at least part of the sex difference in liver cancer risk.</abstract><cop>Cary, NC</cop><pub>Oxford University Press</pub><pmid>19224979</pmid><doi>10.1093/aje/kwn418</doi><tpages>6</tpages><oa>free_for_read</oa></addata></record> |
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| source | Oxford University Press Journals All Titles (1996-Current); MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; Alma/SFX Local Collection |
| subjects | Adult Age Factors Aged Alcohol Drinking - epidemiology Analysis. Health state Biological and medical sciences Cancer Carcinoma, Hepatocellular - mortality Carrier State - epidemiology China China - epidemiology cohort studies Comorbidity Epidemiology Female Gastroenterology. Liver. Pancreas. Abdomen Gender differences General aspects Hepatitis Hepatitis B - epidemiology Hepatitis B virus Human viral diseases Humans Infectious diseases Liver diseases liver neoplasms Liver Neoplasms - mortality Liver. Biliary tract. Portal circulation. Exocrine pancreas Longitudinal Studies Male Medical sciences Middle Aged Miscellaneous Mortality Public health. Hygiene Public health. Hygiene-occupational medicine Risk Assessment Risk factors sex Sex Distribution Sex Factors Smoking - epidemiology Tumors Viral diseases Viral hepatitis |
| title | Sex-Modified Effect of Hepatitis B Virus Infection on Mortality From Primary Liver Cancer |
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