Antituberculosis drug resistance and associated risk factors in the European section of Turkey
We carried out this study in order to establish the prevalence of antituberculosis drug resistance in Mycobacterium tuberculosis strains and to determine risk factors for the development of resistance in Trakya region of Turkey. Pattern of drug resistance in 214 M. tuberculosis isolates from patient...
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| Veröffentlicht in: | Indian journal of chest diseases & allied sciences 2004-07, Vol.46 (3), p.171-177 |
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| container_title | Indian journal of chest diseases & allied sciences |
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| creator | Karabay, Oguz Otkun, Metin Akata, Filiz Karlikaya, Celal Tuğrul, Murat Dündar, Volkan |
| description | We carried out this study in order to establish the prevalence of antituberculosis drug resistance in Mycobacterium tuberculosis strains and to determine risk factors for the development of resistance in Trakya region of Turkey.
Pattern of drug resistance in 214 M. tuberculosis isolates from patients with tuberculosis treated at the regional tuberculosis dispensaries were included in the study.
Isolates of 105 (49.1%) were resistant to only one drug, and 62 (29.0%) were resistant to more than one drug. The total resistance rates to streptomycin, isoniazid, rifampicin, ethambutol and isoniazid + rifampicin were 29.0%, 27.1%, 21.5%, 10.3% and 11.6%, respectively. The secondary resistance rates in all drugs and combinations were higher than primary resistance rates (p |
| format | Article |
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Pattern of drug resistance in 214 M. tuberculosis isolates from patients with tuberculosis treated at the regional tuberculosis dispensaries were included in the study.
Isolates of 105 (49.1%) were resistant to only one drug, and 62 (29.0%) were resistant to more than one drug. The total resistance rates to streptomycin, isoniazid, rifampicin, ethambutol and isoniazid + rifampicin were 29.0%, 27.1%, 21.5%, 10.3% and 11.6%, respectively. The secondary resistance rates in all drugs and combinations were higher than primary resistance rates (p<0.001). Step wise logistic regression revealed that (i) non-compliance with treatment increases the chances of development of resistance by 15 times [p<0.00001, 95% confidence intervals (95% CI) : 4.16 to 56.70], and (ii) a regimen of inadequate treatment increases the chance of development of drug resistance by 10.5 times (p<0.01, 95% CI=2.66 to 49.80).
We propose that specially trained physicians should institute antituberculosis therapy and medication should be practiced under direct observation in this region.</description><identifier>ISSN: 0377-9343</identifier><identifier>PMID: 15553205</identifier><language>eng</language><publisher>India</publisher><subject>Adolescent ; Adult ; Aged ; Aged, 80 and over ; Antitubercular Agents - pharmacology ; Antitubercular Agents - therapeutic use ; Child ; Child, Preschool ; Drug Resistance, Bacterial ; Female ; Humans ; Male ; Microbial Sensitivity Tests ; Middle Aged ; Mycobacterium tuberculosis - drug effects ; Risk Factors ; Tuberculosis, Multidrug-Resistant - drug therapy ; Tuberculosis, Multidrug-Resistant - etiology ; Tuberculosis, Multidrug-Resistant - microbiology ; Tuberculosis, Pulmonary - drug therapy ; Tuberculosis, Pulmonary - etiology ; Tuberculosis, Pulmonary - microbiology ; Turkey</subject><ispartof>Indian journal of chest diseases & allied sciences, 2004-07, Vol.46 (3), p.171-177</ispartof><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,777,781</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/15553205$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Karabay, Oguz</creatorcontrib><creatorcontrib>Otkun, Metin</creatorcontrib><creatorcontrib>Akata, Filiz</creatorcontrib><creatorcontrib>Karlikaya, Celal</creatorcontrib><creatorcontrib>Tuğrul, Murat</creatorcontrib><creatorcontrib>Dündar, Volkan</creatorcontrib><title>Antituberculosis drug resistance and associated risk factors in the European section of Turkey</title><title>Indian journal of chest diseases & allied sciences</title><addtitle>Indian J Chest Dis Allied Sci</addtitle><description>We carried out this study in order to establish the prevalence of antituberculosis drug resistance in Mycobacterium tuberculosis strains and to determine risk factors for the development of resistance in Trakya region of Turkey.
Pattern of drug resistance in 214 M. tuberculosis isolates from patients with tuberculosis treated at the regional tuberculosis dispensaries were included in the study.
Isolates of 105 (49.1%) were resistant to only one drug, and 62 (29.0%) were resistant to more than one drug. The total resistance rates to streptomycin, isoniazid, rifampicin, ethambutol and isoniazid + rifampicin were 29.0%, 27.1%, 21.5%, 10.3% and 11.6%, respectively. The secondary resistance rates in all drugs and combinations were higher than primary resistance rates (p<0.001). Step wise logistic regression revealed that (i) non-compliance with treatment increases the chances of development of resistance by 15 times [p<0.00001, 95% confidence intervals (95% CI) : 4.16 to 56.70], and (ii) a regimen of inadequate treatment increases the chance of development of drug resistance by 10.5 times (p<0.01, 95% CI=2.66 to 49.80).
We propose that specially trained physicians should institute antituberculosis therapy and medication should be practiced under direct observation in this region.</description><subject>Adolescent</subject><subject>Adult</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Antitubercular Agents - pharmacology</subject><subject>Antitubercular Agents - therapeutic use</subject><subject>Child</subject><subject>Child, Preschool</subject><subject>Drug Resistance, Bacterial</subject><subject>Female</subject><subject>Humans</subject><subject>Male</subject><subject>Microbial Sensitivity Tests</subject><subject>Middle Aged</subject><subject>Mycobacterium tuberculosis - drug effects</subject><subject>Risk Factors</subject><subject>Tuberculosis, Multidrug-Resistant - drug therapy</subject><subject>Tuberculosis, Multidrug-Resistant - etiology</subject><subject>Tuberculosis, Multidrug-Resistant - microbiology</subject><subject>Tuberculosis, Pulmonary - drug therapy</subject><subject>Tuberculosis, Pulmonary - etiology</subject><subject>Tuberculosis, Pulmonary - microbiology</subject><subject>Turkey</subject><issn>0377-9343</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2004</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNo10DtPwzAUBeAMIFoKfwF5Yotkx69mrKrykCqxlJXoxr4B09QOfgz990SiTOcMn85wrqol5VrXLRd8Ud2m9E1pI0XLbqoFk1Lyhspl9bHx2eXSYzRlDMklYmP5JBHnmsEbJOAtgZSCcZDRkujSkQxgcoiJOE_yF5JdiWFC8CShyS54EgZyKPGI57vqeoAx4f0lV9X70-6wfan3b8-v282-nlgjcs2VBaHWa2a5XltmpOqttS1QipYLxZTqG8mgV5wzDoNC0K0yanZy6Adj-ap6_NudYvgpmHJ3csngOILHUFKnNNVCCD3Dhwss_QltN0V3gnju_h_hv1YdXaY</recordid><startdate>200407</startdate><enddate>200407</enddate><creator>Karabay, Oguz</creator><creator>Otkun, Metin</creator><creator>Akata, Filiz</creator><creator>Karlikaya, Celal</creator><creator>Tuğrul, Murat</creator><creator>Dündar, Volkan</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7X8</scope></search><sort><creationdate>200407</creationdate><title>Antituberculosis drug resistance and associated risk factors in the European section of Turkey</title><author>Karabay, Oguz ; Otkun, Metin ; Akata, Filiz ; Karlikaya, Celal ; Tuğrul, Murat ; Dündar, Volkan</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-p124t-36da46881d378d1c56bddd9a00ed346166b251ab63313af6ea796c6c565fbfcd3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2004</creationdate><topic>Adolescent</topic><topic>Adult</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Antitubercular Agents - pharmacology</topic><topic>Antitubercular Agents - therapeutic use</topic><topic>Child</topic><topic>Child, Preschool</topic><topic>Drug Resistance, Bacterial</topic><topic>Female</topic><topic>Humans</topic><topic>Male</topic><topic>Microbial Sensitivity Tests</topic><topic>Middle Aged</topic><topic>Mycobacterium tuberculosis - drug effects</topic><topic>Risk Factors</topic><topic>Tuberculosis, Multidrug-Resistant - drug therapy</topic><topic>Tuberculosis, Multidrug-Resistant - etiology</topic><topic>Tuberculosis, Multidrug-Resistant - microbiology</topic><topic>Tuberculosis, Pulmonary - drug therapy</topic><topic>Tuberculosis, Pulmonary - etiology</topic><topic>Tuberculosis, Pulmonary - microbiology</topic><topic>Turkey</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Karabay, Oguz</creatorcontrib><creatorcontrib>Otkun, Metin</creatorcontrib><creatorcontrib>Akata, Filiz</creatorcontrib><creatorcontrib>Karlikaya, Celal</creatorcontrib><creatorcontrib>Tuğrul, Murat</creatorcontrib><creatorcontrib>Dündar, Volkan</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>MEDLINE - Academic</collection><jtitle>Indian journal of chest diseases & allied sciences</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Karabay, Oguz</au><au>Otkun, Metin</au><au>Akata, Filiz</au><au>Karlikaya, Celal</au><au>Tuğrul, Murat</au><au>Dündar, Volkan</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Antituberculosis drug resistance and associated risk factors in the European section of Turkey</atitle><jtitle>Indian journal of chest diseases & allied sciences</jtitle><addtitle>Indian J Chest Dis Allied Sci</addtitle><date>2004-07</date><risdate>2004</risdate><volume>46</volume><issue>3</issue><spage>171</spage><epage>177</epage><pages>171-177</pages><issn>0377-9343</issn><abstract>We carried out this study in order to establish the prevalence of antituberculosis drug resistance in Mycobacterium tuberculosis strains and to determine risk factors for the development of resistance in Trakya region of Turkey.
Pattern of drug resistance in 214 M. tuberculosis isolates from patients with tuberculosis treated at the regional tuberculosis dispensaries were included in the study.
Isolates of 105 (49.1%) were resistant to only one drug, and 62 (29.0%) were resistant to more than one drug. The total resistance rates to streptomycin, isoniazid, rifampicin, ethambutol and isoniazid + rifampicin were 29.0%, 27.1%, 21.5%, 10.3% and 11.6%, respectively. The secondary resistance rates in all drugs and combinations were higher than primary resistance rates (p<0.001). Step wise logistic regression revealed that (i) non-compliance with treatment increases the chances of development of resistance by 15 times [p<0.00001, 95% confidence intervals (95% CI) : 4.16 to 56.70], and (ii) a regimen of inadequate treatment increases the chance of development of drug resistance by 10.5 times (p<0.01, 95% CI=2.66 to 49.80).
We propose that specially trained physicians should institute antituberculosis therapy and medication should be practiced under direct observation in this region.</abstract><cop>India</cop><pmid>15553205</pmid><tpages>7</tpages></addata></record> |
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| ispartof | Indian journal of chest diseases & allied sciences, 2004-07, Vol.46 (3), p.171-177 |
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| subjects | Adolescent Adult Aged Aged, 80 and over Antitubercular Agents - pharmacology Antitubercular Agents - therapeutic use Child Child, Preschool Drug Resistance, Bacterial Female Humans Male Microbial Sensitivity Tests Middle Aged Mycobacterium tuberculosis - drug effects Risk Factors Tuberculosis, Multidrug-Resistant - drug therapy Tuberculosis, Multidrug-Resistant - etiology Tuberculosis, Multidrug-Resistant - microbiology Tuberculosis, Pulmonary - drug therapy Tuberculosis, Pulmonary - etiology Tuberculosis, Pulmonary - microbiology Turkey |
| title | Antituberculosis drug resistance and associated risk factors in the European section of Turkey |
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