A Model of Net Amino Acid Absorption and Utilization by the Portal-Drained Viscera of the Lactating Dairy Cow
A more complete understanding of amino acid (AA) metabolism by the various tissues of the body is required to improve upon current systems for predicting the use of absorbed AA. The objective of this work was to construct and parameterize a model of net removal of AA by the portal-drained viscera (P...
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| Veröffentlicht in: | Journal of dairy science 2004-12, Vol.87 (12), p.4247-4268 |
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| creator | Hanigan, M.D. Reynolds, C.K. Humphries, D.J. Lupoli, B. Sutton, J.D. |
| description | A more complete understanding of amino acid (AA) metabolism by the various tissues of the body is required to improve upon current systems for predicting the use of absorbed AA. The objective of this work was to construct and parameterize a model of net removal of AA by the portal-drained viscera (PDV). Six cows were prepared with arterial, portal, and hepatic catheters and infused abomasally with 0, 200, 400, or 600g of casein daily. Casein infusion increased milk yield quadratically and tended to increase milk protein yield quadratically. Arterial concentrations of a number of essential AA increased linearly with respect to infusion amount. When infused casein was assumed to have a true digestion coefficient of 0.95, the minimum likely true digestion coefficient for noninfused duodenal protein was found to be 0.80. Net PDV use of AA appeared to be linearly related to total supply (arterial plus absorption), and extraction percentages ranged from 0.5 to 7.25% for essential AA. Prediction errors for portal vein AA concentrations ranged from 4 to 9% of the observed mean concentrations. Removal of AA by PDV represented approximately 33% of total postabsorptive catabolic use, including use during absorption but excluding use for milk protein synthesis, and was apparently adequate to support endogenous N losses in feces of 18.4 g/d. As 69% of this use was from arterial blood, increased PDV catabolism of AA in part represents increased absorption of AA in excess of amounts required by other body tissues. Based on the present model, increased anabolic use of AA in the mammary and other tissues would reduce the catabolic use of AA by the PDV. |
| doi_str_mv | 10.3168/jds.S0022-0302(04)73570-5 |
| format | Article |
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The objective of this work was to construct and parameterize a model of net removal of AA by the portal-drained viscera (PDV). Six cows were prepared with arterial, portal, and hepatic catheters and infused abomasally with 0, 200, 400, or 600g of casein daily. Casein infusion increased milk yield quadratically and tended to increase milk protein yield quadratically. Arterial concentrations of a number of essential AA increased linearly with respect to infusion amount. When infused casein was assumed to have a true digestion coefficient of 0.95, the minimum likely true digestion coefficient for noninfused duodenal protein was found to be 0.80. Net PDV use of AA appeared to be linearly related to total supply (arterial plus absorption), and extraction percentages ranged from 0.5 to 7.25% for essential AA. Prediction errors for portal vein AA concentrations ranged from 4 to 9% of the observed mean concentrations. Removal of AA by PDV represented approximately 33% of total postabsorptive catabolic use, including use during absorption but excluding use for milk protein synthesis, and was apparently adequate to support endogenous N losses in feces of 18.4 g/d. As 69% of this use was from arterial blood, increased PDV catabolism of AA in part represents increased absorption of AA in excess of amounts required by other body tissues. Based on the present model, increased anabolic use of AA in the mammary and other tissues would reduce the catabolic use of AA by the PDV.</description><identifier>ISSN: 0022-0302</identifier><identifier>EISSN: 1525-3198</identifier><identifier>DOI: 10.3168/jds.S0022-0302(04)73570-5</identifier><identifier>PMID: 15545389</identifier><identifier>CODEN: JDSCAE</identifier><language>eng</language><publisher>Savoy, IL: Elsevier Inc</publisher><subject>amino acids ; Animal productions ; Animals ; Biological and medical sciences ; Caseins - blood ; Caseins - metabolism ; Caseins - pharmacokinetics ; cattle ; Cattle - physiology ; Dose-Response Relationship, Drug ; Feces - chemistry ; Female ; Food industries ; Fundamental and applied biological sciences. Psychology ; Intestinal Absorption - drug effects ; Lactation - metabolism ; Lactation - physiology ; Milk - chemistry ; Milk - drug effects ; Milk - secretion ; Milk and cheese industries. Ice creams ; Milk Proteins - analysis ; Milk Proteins - metabolism ; Models, Biological ; net removal ; Portal System ; Portal Vein - metabolism ; portal-drained viscera ; Splanchnic Circulation ; Terrestrial animal productions ; Vertebrates ; Viscera - blood supply ; Viscera - metabolism</subject><ispartof>Journal of dairy science, 2004-12, Vol.87 (12), p.4247-4268</ispartof><rights>2004 American Dairy Science Association</rights><rights>2005 INIST-CNRS</rights><rights>Copyright American Dairy Science Association Dec 2004</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c515t-a8b9ccd2f3a564bf9b36343eacd3d2532330b0faa55de9af7ae92da9a6ed3a2d3</citedby><cites>FETCH-LOGICAL-c515t-a8b9ccd2f3a564bf9b36343eacd3d2532330b0faa55de9af7ae92da9a6ed3a2d3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.3168/jds.S0022-0302(04)73570-5$$EHTML$$P50$$Gelsevier$$Hfree_for_read</linktohtml><link.rule.ids>314,780,784,3550,27924,27925,45995</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=16302064$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/15545389$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Hanigan, M.D.</creatorcontrib><creatorcontrib>Reynolds, C.K.</creatorcontrib><creatorcontrib>Humphries, D.J.</creatorcontrib><creatorcontrib>Lupoli, B.</creatorcontrib><creatorcontrib>Sutton, J.D.</creatorcontrib><title>A Model of Net Amino Acid Absorption and Utilization by the Portal-Drained Viscera of the Lactating Dairy Cow</title><title>Journal of dairy science</title><addtitle>J Dairy Sci</addtitle><description>A more complete understanding of amino acid (AA) metabolism by the various tissues of the body is required to improve upon current systems for predicting the use of absorbed AA. The objective of this work was to construct and parameterize a model of net removal of AA by the portal-drained viscera (PDV). Six cows were prepared with arterial, portal, and hepatic catheters and infused abomasally with 0, 200, 400, or 600g of casein daily. Casein infusion increased milk yield quadratically and tended to increase milk protein yield quadratically. Arterial concentrations of a number of essential AA increased linearly with respect to infusion amount. When infused casein was assumed to have a true digestion coefficient of 0.95, the minimum likely true digestion coefficient for noninfused duodenal protein was found to be 0.80. Net PDV use of AA appeared to be linearly related to total supply (arterial plus absorption), and extraction percentages ranged from 0.5 to 7.25% for essential AA. Prediction errors for portal vein AA concentrations ranged from 4 to 9% of the observed mean concentrations. Removal of AA by PDV represented approximately 33% of total postabsorptive catabolic use, including use during absorption but excluding use for milk protein synthesis, and was apparently adequate to support endogenous N losses in feces of 18.4 g/d. As 69% of this use was from arterial blood, increased PDV catabolism of AA in part represents increased absorption of AA in excess of amounts required by other body tissues. Based on the present model, increased anabolic use of AA in the mammary and other tissues would reduce the catabolic use of AA by the PDV.</description><subject>amino acids</subject><subject>Animal productions</subject><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>Caseins - blood</subject><subject>Caseins - metabolism</subject><subject>Caseins - pharmacokinetics</subject><subject>cattle</subject><subject>Cattle - physiology</subject><subject>Dose-Response Relationship, Drug</subject><subject>Feces - chemistry</subject><subject>Female</subject><subject>Food industries</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Intestinal Absorption - drug effects</subject><subject>Lactation - metabolism</subject><subject>Lactation - physiology</subject><subject>Milk - chemistry</subject><subject>Milk - drug effects</subject><subject>Milk - secretion</subject><subject>Milk and cheese industries. Ice creams</subject><subject>Milk Proteins - analysis</subject><subject>Milk Proteins - metabolism</subject><subject>Models, Biological</subject><subject>net removal</subject><subject>Portal System</subject><subject>Portal Vein - metabolism</subject><subject>portal-drained viscera</subject><subject>Splanchnic Circulation</subject><subject>Terrestrial animal productions</subject><subject>Vertebrates</subject><subject>Viscera - blood supply</subject><subject>Viscera - metabolism</subject><issn>0022-0302</issn><issn>1525-3198</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2004</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNqNkUuP0zAUhS0EYsrAX0AGidcig59JvIw6vKTykGDYWje2M3WVxB07ZVR-PU5bMRIrVtaVv3Pu0T0IPaPkgtOyfrux6eI7IYwVhBP2mog3FZcVKeQ9tKCSyYJTVd9Hi7_IGXqU0iaPlBH5EJ1RKYXktVqgocGfg3U9Dh3-4ibcDH4MuDHe4qZNIW4nH0YMo8VXk-_9bzjM7R5Pa4e_hThBX1xG8KOz-KdPxkWYrebfFZgp4-M1vgQf93gZbh-jBx30yT05vefo6v27H8uPxerrh0_LZlUYSeVUQN0qYyzrOMhStJ1qeckFd2Ast0xyxjlpSQcgpXUKugqcYhYUlM5yYJafo5dH320MNzuXJj3M2foeRhd2SZcVqQSt6ww-_wfchF0cczZNlayZkqXKkDpCJoaUouv0NvoB4l5ToudCdC5EHwrR87U1EfpQiJZZ-_S0YNcOzt4pTw1k4MUJgGSg7yKMxqc7rsyGpBSZe3Xk1v56feuj02mAvs-2dF5fV5oyLZioMrk8ki5f-Jd3USfj3WiczSozaRv8fwT_A8u5t7U</recordid><startdate>20041201</startdate><enddate>20041201</enddate><creator>Hanigan, M.D.</creator><creator>Reynolds, C.K.</creator><creator>Humphries, D.J.</creator><creator>Lupoli, B.</creator><creator>Sutton, J.D.</creator><general>Elsevier Inc</general><general>Am Dairy Sci Assoc</general><general>American Dairy Science Association</general><scope>6I.</scope><scope>AAFTH</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X2</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8FE</scope><scope>8FG</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABJCF</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>ATCPS</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>BGLVJ</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>L6V</scope><scope>M0K</scope><scope>M0S</scope><scope>M1P</scope><scope>M7S</scope><scope>PATMY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>PTHSS</scope><scope>PYCSY</scope><scope>S0X</scope><scope>7X8</scope></search><sort><creationdate>20041201</creationdate><title>A Model of Net Amino Acid Absorption and Utilization by the Portal-Drained Viscera of the Lactating Dairy Cow</title><author>Hanigan, M.D. ; Reynolds, C.K. ; Humphries, D.J. ; Lupoli, B. ; Sutton, J.D.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c515t-a8b9ccd2f3a564bf9b36343eacd3d2532330b0faa55de9af7ae92da9a6ed3a2d3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2004</creationdate><topic>amino acids</topic><topic>Animal productions</topic><topic>Animals</topic><topic>Biological and medical sciences</topic><topic>Caseins - blood</topic><topic>Caseins - metabolism</topic><topic>Caseins - pharmacokinetics</topic><topic>cattle</topic><topic>Cattle - physiology</topic><topic>Dose-Response Relationship, Drug</topic><topic>Feces - chemistry</topic><topic>Female</topic><topic>Food industries</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Intestinal Absorption - drug effects</topic><topic>Lactation - metabolism</topic><topic>Lactation - physiology</topic><topic>Milk - chemistry</topic><topic>Milk - drug effects</topic><topic>Milk - secretion</topic><topic>Milk and cheese industries. Ice creams</topic><topic>Milk Proteins - analysis</topic><topic>Milk Proteins - metabolism</topic><topic>Models, Biological</topic><topic>net removal</topic><topic>Portal System</topic><topic>Portal Vein - metabolism</topic><topic>portal-drained viscera</topic><topic>Splanchnic Circulation</topic><topic>Terrestrial animal productions</topic><topic>Vertebrates</topic><topic>Viscera - blood supply</topic><topic>Viscera - metabolism</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Hanigan, M.D.</creatorcontrib><creatorcontrib>Reynolds, C.K.</creatorcontrib><creatorcontrib>Humphries, D.J.</creatorcontrib><creatorcontrib>Lupoli, B.</creatorcontrib><creatorcontrib>Sutton, J.D.</creatorcontrib><collection>ScienceDirect Open Access Titles</collection><collection>Elsevier:ScienceDirect:Open Access</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Agricultural Science Collection</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Technology Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Materials Science & Engineering Collection</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>Agricultural & Environmental Science Collection</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>Technology Collection</collection><collection>Natural Science Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>ProQuest Engineering Collection</collection><collection>Agricultural Science Database</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Engineering Database</collection><collection>Environmental Science Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>Engineering Collection</collection><collection>Environmental Science Collection</collection><collection>SIRS Editorial</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of dairy science</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Hanigan, M.D.</au><au>Reynolds, C.K.</au><au>Humphries, D.J.</au><au>Lupoli, B.</au><au>Sutton, J.D.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>A Model of Net Amino Acid Absorption and Utilization by the Portal-Drained Viscera of the Lactating Dairy Cow</atitle><jtitle>Journal of dairy science</jtitle><addtitle>J Dairy Sci</addtitle><date>2004-12-01</date><risdate>2004</risdate><volume>87</volume><issue>12</issue><spage>4247</spage><epage>4268</epage><pages>4247-4268</pages><issn>0022-0302</issn><eissn>1525-3198</eissn><coden>JDSCAE</coden><abstract>A more complete understanding of amino acid (AA) metabolism by the various tissues of the body is required to improve upon current systems for predicting the use of absorbed AA. The objective of this work was to construct and parameterize a model of net removal of AA by the portal-drained viscera (PDV). Six cows were prepared with arterial, portal, and hepatic catheters and infused abomasally with 0, 200, 400, or 600g of casein daily. Casein infusion increased milk yield quadratically and tended to increase milk protein yield quadratically. Arterial concentrations of a number of essential AA increased linearly with respect to infusion amount. When infused casein was assumed to have a true digestion coefficient of 0.95, the minimum likely true digestion coefficient for noninfused duodenal protein was found to be 0.80. Net PDV use of AA appeared to be linearly related to total supply (arterial plus absorption), and extraction percentages ranged from 0.5 to 7.25% for essential AA. Prediction errors for portal vein AA concentrations ranged from 4 to 9% of the observed mean concentrations. Removal of AA by PDV represented approximately 33% of total postabsorptive catabolic use, including use during absorption but excluding use for milk protein synthesis, and was apparently adequate to support endogenous N losses in feces of 18.4 g/d. As 69% of this use was from arterial blood, increased PDV catabolism of AA in part represents increased absorption of AA in excess of amounts required by other body tissues. Based on the present model, increased anabolic use of AA in the mammary and other tissues would reduce the catabolic use of AA by the PDV.</abstract><cop>Savoy, IL</cop><pub>Elsevier Inc</pub><pmid>15545389</pmid><doi>10.3168/jds.S0022-0302(04)73570-5</doi><tpages>22</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | Journal of dairy science, 2004-12, Vol.87 (12), p.4247-4268 |
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| subjects | amino acids Animal productions Animals Biological and medical sciences Caseins - blood Caseins - metabolism Caseins - pharmacokinetics cattle Cattle - physiology Dose-Response Relationship, Drug Feces - chemistry Female Food industries Fundamental and applied biological sciences. Psychology Intestinal Absorption - drug effects Lactation - metabolism Lactation - physiology Milk - chemistry Milk - drug effects Milk - secretion Milk and cheese industries. Ice creams Milk Proteins - analysis Milk Proteins - metabolism Models, Biological net removal Portal System Portal Vein - metabolism portal-drained viscera Splanchnic Circulation Terrestrial animal productions Vertebrates Viscera - blood supply Viscera - metabolism |
| title | A Model of Net Amino Acid Absorption and Utilization by the Portal-Drained Viscera of the Lactating Dairy Cow |
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