Effects of cyclooxygenase inhibition on anastomotic healing following large bowel resection in a rabbit model--a randomized, blinded, placebo-controlled trial
Purpose We performed an experimental study in a rabbit model to investigate the effects of a selective Cox-2 inhibitor (Valdecoxib) on anastomotic healing following large bowel resection after 1 week. Materials and methods Eighty New Zealand white rabbits were randomized into four groups and underwe...
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| Veröffentlicht in: | International journal of colorectal disease 2009-05, Vol.24 (5), p.551-557 |
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| container_title | International journal of colorectal disease |
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| creator | Neuss, Heiko Raue, Wieland Müller, Verena Weichert, Wilko Schwenk, Wolfgang Mall, Julian W |
| description | Purpose We performed an experimental study in a rabbit model to investigate the effects of a selective Cox-2 inhibitor (Valdecoxib) on anastomotic healing following large bowel resection after 1 week. Materials and methods Eighty New Zealand white rabbits were randomized into four groups and underwent a colon resection with end-to-end anastomosis. Group 1 (n = 20) was treated with Valdecoxib, group 2 with Metamizole (Novalgin®), group 3 with Resveratrol (specific Cox-1 inhibitor), or a placebo vehicle with similar volume (group 4). Anastomotic healing was tested at the seventh postoperative day by measurement of the bursting pressure in vitro. Immunohistochemical staining of the anastomotic site was performed with polyclonal antibodies (CD31). Results There were no significant differences in anastomotic dehiscence, bursting pressure, or vessel density between the treatment and control groups. Conclusion The application of Valdecoxib does not influence anastomotic healing or new vessel formation in the anastomotic region following large bowel resection. |
| doi_str_mv | 10.1007/s00384-009-0643-0 |
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Materials and methods Eighty New Zealand white rabbits were randomized into four groups and underwent a colon resection with end-to-end anastomosis. Group 1 (n = 20) was treated with Valdecoxib, group 2 with Metamizole (Novalgin®), group 3 with Resveratrol (specific Cox-1 inhibitor), or a placebo vehicle with similar volume (group 4). Anastomotic healing was tested at the seventh postoperative day by measurement of the bursting pressure in vitro. Immunohistochemical staining of the anastomotic site was performed with polyclonal antibodies (CD31). Results There were no significant differences in anastomotic dehiscence, bursting pressure, or vessel density between the treatment and control groups. Conclusion The application of Valdecoxib does not influence anastomotic healing or new vessel formation in the anastomotic region following large bowel resection.</description><identifier>ISSN: 0179-1958</identifier><identifier>EISSN: 1432-1262</identifier><identifier>DOI: 10.1007/s00384-009-0643-0</identifier><identifier>PMID: 19184064</identifier><identifier>CODEN: IJCDE6</identifier><language>eng</language><publisher>Berlin/Heidelberg: Berlin/Heidelberg : Springer-Verlag</publisher><subject>Anastomosis, Surgical - adverse effects ; Anastomotic healing ; Animal model ; Animals ; Biological and medical sciences ; Bursting pressure ; Cox-2 ; Creatinine - blood ; Cyclooxygenase Inhibitors - pharmacology ; Gastroenterology ; Gastroenterology. Liver. Pancreas. Abdomen ; Hepatology ; Internal Medicine ; Intestine, Large - blood supply ; Intestine, Large - pathology ; Intestine, Large - surgery ; Isoxazoles - pharmacology ; Medical sciences ; Medicine ; Medicine & Public Health ; Models, Animal ; Original Article ; Postoperative Complications - etiology ; Pressure ; Proctology ; prostaglandin synthase ; Rabbits ; Sulfonamides - pharmacology ; Surgery ; Wound Healing - drug effects</subject><ispartof>International journal of colorectal disease, 2009-05, Vol.24 (5), p.551-557</ispartof><rights>Springer-Verlag 2009</rights><rights>2009 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c423t-9c8b2598710e67ee478f183c11a88e27146eb6da3a98df0822d121bf2d44c7513</citedby><cites>FETCH-LOGICAL-c423t-9c8b2598710e67ee478f183c11a88e27146eb6da3a98df0822d121bf2d44c7513</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s00384-009-0643-0$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s00384-009-0643-0$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,780,784,27924,27925,41488,42557,51319</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=21300780$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/19184064$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Neuss, Heiko</creatorcontrib><creatorcontrib>Raue, Wieland</creatorcontrib><creatorcontrib>Müller, Verena</creatorcontrib><creatorcontrib>Weichert, Wilko</creatorcontrib><creatorcontrib>Schwenk, Wolfgang</creatorcontrib><creatorcontrib>Mall, Julian W</creatorcontrib><title>Effects of cyclooxygenase inhibition on anastomotic healing following large bowel resection in a rabbit model--a randomized, blinded, placebo-controlled trial</title><title>International journal of colorectal disease</title><addtitle>Int J Colorectal Dis</addtitle><addtitle>Int J Colorectal Dis</addtitle><description>Purpose We performed an experimental study in a rabbit model to investigate the effects of a selective Cox-2 inhibitor (Valdecoxib) on anastomotic healing following large bowel resection after 1 week. Materials and methods Eighty New Zealand white rabbits were randomized into four groups and underwent a colon resection with end-to-end anastomosis. Group 1 (n = 20) was treated with Valdecoxib, group 2 with Metamizole (Novalgin®), group 3 with Resveratrol (specific Cox-1 inhibitor), or a placebo vehicle with similar volume (group 4). Anastomotic healing was tested at the seventh postoperative day by measurement of the bursting pressure in vitro. Immunohistochemical staining of the anastomotic site was performed with polyclonal antibodies (CD31). Results There were no significant differences in anastomotic dehiscence, bursting pressure, or vessel density between the treatment and control groups. Conclusion The application of Valdecoxib does not influence anastomotic healing or new vessel formation in the anastomotic region following large bowel resection.</description><subject>Anastomosis, Surgical - adverse effects</subject><subject>Anastomotic healing</subject><subject>Animal model</subject><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>Bursting pressure</subject><subject>Cox-2</subject><subject>Creatinine - blood</subject><subject>Cyclooxygenase Inhibitors - pharmacology</subject><subject>Gastroenterology</subject><subject>Gastroenterology. Liver. Pancreas. Abdomen</subject><subject>Hepatology</subject><subject>Internal Medicine</subject><subject>Intestine, Large - blood supply</subject><subject>Intestine, Large - pathology</subject><subject>Intestine, Large - surgery</subject><subject>Isoxazoles - pharmacology</subject><subject>Medical sciences</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Models, Animal</subject><subject>Original Article</subject><subject>Postoperative Complications - etiology</subject><subject>Pressure</subject><subject>Proctology</subject><subject>prostaglandin synthase</subject><subject>Rabbits</subject><subject>Sulfonamides - pharmacology</subject><subject>Surgery</subject><subject>Wound Healing - drug effects</subject><issn>0179-1958</issn><issn>1432-1262</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2009</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><recordid>eNp9kc1u1DAUhSMEotPCA7ABCwlWGHwdT-wsq6r8SJVYQNeW41ynrpx4sDNqh4fhWXHIiEoskCz52j7nu9Y9VfUC2HtgTH7IjNVKUMZayhpRU_ao2oCoOQXe8MfVhoFsKbRbdVKd5nzLyrmR4ml1Ai0oUSyb6telc2jnTKIj9mBDjPeHASeTkfjpxnd-9nEiZZlyN8cxzt6SGzTBTwNxMYR4t1TBpAFJF-8wkIS5EBebLzaSTFcoZIw9BkqX89TH0f_E_h3pCqZfil0wFrtIbZzmVKjYkzl5E55VT5wJGZ8f97Pq-uPl94vP9Orrpy8X51fUCl7PtLWq49tWSWDYSEQhlQNVWwCjFHIJosGu6U1tWtU7pjjvgUPneC-ElVuoz6q3K3eX4o895lmPPlsMwUwY91k3kskyPFaEr_8R3sZ9msrfNIemkJhaRLCKbIo5J3R6l_xo0kED00tyek1Ol-T0kpxePC-P4H03Yv_gOEZVBG-OApOtCa7M0fr8V8dLayb_NOerLpenacD08MP_dX-1mpyJ2gypgK-_cVaY0ACItq5_AwQwu30</recordid><startdate>20090501</startdate><enddate>20090501</enddate><creator>Neuss, Heiko</creator><creator>Raue, Wieland</creator><creator>Müller, Verena</creator><creator>Weichert, Wilko</creator><creator>Schwenk, Wolfgang</creator><creator>Mall, Julian W</creator><general>Berlin/Heidelberg : Springer-Verlag</general><general>Springer-Verlag</general><general>Springer</general><general>Springer Nature B.V</general><scope>FBQ</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7T5</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>H94</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope></search><sort><creationdate>20090501</creationdate><title>Effects of cyclooxygenase inhibition on anastomotic healing following large bowel resection in a rabbit model--a randomized, blinded, placebo-controlled trial</title><author>Neuss, Heiko ; Raue, Wieland ; Müller, Verena ; Weichert, Wilko ; Schwenk, Wolfgang ; Mall, Julian W</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c423t-9c8b2598710e67ee478f183c11a88e27146eb6da3a98df0822d121bf2d44c7513</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2009</creationdate><topic>Anastomosis, Surgical - adverse effects</topic><topic>Anastomotic healing</topic><topic>Animal model</topic><topic>Animals</topic><topic>Biological and medical sciences</topic><topic>Bursting pressure</topic><topic>Cox-2</topic><topic>Creatinine - blood</topic><topic>Cyclooxygenase Inhibitors - pharmacology</topic><topic>Gastroenterology</topic><topic>Gastroenterology. Liver. Pancreas. Abdomen</topic><topic>Hepatology</topic><topic>Internal Medicine</topic><topic>Intestine, Large - blood supply</topic><topic>Intestine, Large - pathology</topic><topic>Intestine, Large - surgery</topic><topic>Isoxazoles - pharmacology</topic><topic>Medical sciences</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Models, Animal</topic><topic>Original Article</topic><topic>Postoperative Complications - etiology</topic><topic>Pressure</topic><topic>Proctology</topic><topic>prostaglandin synthase</topic><topic>Rabbits</topic><topic>Sulfonamides - pharmacology</topic><topic>Surgery</topic><topic>Wound Healing - drug effects</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Neuss, Heiko</creatorcontrib><creatorcontrib>Raue, Wieland</creatorcontrib><creatorcontrib>Müller, Verena</creatorcontrib><creatorcontrib>Weichert, Wilko</creatorcontrib><creatorcontrib>Schwenk, Wolfgang</creatorcontrib><creatorcontrib>Mall, Julian W</creatorcontrib><collection>AGRIS</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Immunology Abstracts</collection><collection>ProQuest Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>PML(ProQuest Medical Library)</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><jtitle>International journal of colorectal disease</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Neuss, Heiko</au><au>Raue, Wieland</au><au>Müller, Verena</au><au>Weichert, Wilko</au><au>Schwenk, Wolfgang</au><au>Mall, Julian W</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Effects of cyclooxygenase inhibition on anastomotic healing following large bowel resection in a rabbit model--a randomized, blinded, placebo-controlled trial</atitle><jtitle>International journal of colorectal disease</jtitle><stitle>Int J Colorectal Dis</stitle><addtitle>Int J Colorectal Dis</addtitle><date>2009-05-01</date><risdate>2009</risdate><volume>24</volume><issue>5</issue><spage>551</spage><epage>557</epage><pages>551-557</pages><issn>0179-1958</issn><eissn>1432-1262</eissn><coden>IJCDE6</coden><abstract>Purpose We performed an experimental study in a rabbit model to investigate the effects of a selective Cox-2 inhibitor (Valdecoxib) on anastomotic healing following large bowel resection after 1 week. Materials and methods Eighty New Zealand white rabbits were randomized into four groups and underwent a colon resection with end-to-end anastomosis. Group 1 (n = 20) was treated with Valdecoxib, group 2 with Metamizole (Novalgin®), group 3 with Resveratrol (specific Cox-1 inhibitor), or a placebo vehicle with similar volume (group 4). Anastomotic healing was tested at the seventh postoperative day by measurement of the bursting pressure in vitro. Immunohistochemical staining of the anastomotic site was performed with polyclonal antibodies (CD31). Results There were no significant differences in anastomotic dehiscence, bursting pressure, or vessel density between the treatment and control groups. Conclusion The application of Valdecoxib does not influence anastomotic healing or new vessel formation in the anastomotic region following large bowel resection.</abstract><cop>Berlin/Heidelberg</cop><pub>Berlin/Heidelberg : Springer-Verlag</pub><pmid>19184064</pmid><doi>10.1007/s00384-009-0643-0</doi><tpages>7</tpages></addata></record> |
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| subjects | Anastomosis, Surgical - adverse effects Anastomotic healing Animal model Animals Biological and medical sciences Bursting pressure Cox-2 Creatinine - blood Cyclooxygenase Inhibitors - pharmacology Gastroenterology Gastroenterology. Liver. Pancreas. Abdomen Hepatology Internal Medicine Intestine, Large - blood supply Intestine, Large - pathology Intestine, Large - surgery Isoxazoles - pharmacology Medical sciences Medicine Medicine & Public Health Models, Animal Original Article Postoperative Complications - etiology Pressure Proctology prostaglandin synthase Rabbits Sulfonamides - pharmacology Surgery Wound Healing - drug effects |
| title | Effects of cyclooxygenase inhibition on anastomotic healing following large bowel resection in a rabbit model--a randomized, blinded, placebo-controlled trial |
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