Genistein Acutely Stimulates Nitric Oxide Synthesis in Vascular Endothelial Cells by a Cyclic Adenosine 5′-Monophosphate-Dependent Mechanism

Genistein may improve vascular function, but the mechanism of this effect is unclear. We tested the hypothesis that genistein directly regulates vascular function through stimulation of endothelial nitric oxide synthesis. Genistein activated endothelial nitric oxide synthase (eNOS) in intact bovine...

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Veröffentlicht in:	Endocrinology (Philadelphia) 2004-12, Vol.145 (12), p.5532-5539
Hauptverfasser:	Liu, Dongmin, Homan, Laurie L, Dillon, Joseph S
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenosine monophosphate AKT protein AMP Animals Aorta Aorta - cytology Biological and medical sciences Cattle Cell activation Cyclic AMP - metabolism Cyclic AMP-Dependent Protein Kinases - metabolism Endothelial cells Endothelium, Vascular - cytology Endothelium, Vascular - drug effects Endothelium, Vascular - enzymology Enzyme Inhibitors - pharmacology Estrogen receptors Estrogens Extracellular Signal-Regulated MAP Kinases - metabolism Fundamental and applied biological sciences. Psychology Genistein Genistein - pharmacology Humans Kinases MAP kinase MAP Kinase Signaling System - drug effects Nitric oxide Nitric Oxide - metabolism Nitric Oxide Synthase - antagonists & inhibitors Nitric Oxide Synthase - metabolism Nitric Oxide Synthase Type III Nitric-oxide synthase Phosphatidylinositol 3-Kinases - metabolism Phosphorylation Phytoestrogens Protein biosynthesis Protein kinase A Protein synthesis Protein-Serine-Threonine Kinases - metabolism Protein-Tyrosine Kinases - metabolism Proteins Proto-Oncogene Proteins - metabolism Proto-Oncogene Proteins c-akt Transcription Transcription activation Tyrosine Umbilical vein Umbilical Veins - cytology Vertebrates: endocrinology Xenoestrogens
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