Improved distinction of factor V wild-type and factor V Leiden using a novel prothrombin-based activated protein C resistance assay

A new prothrombin-based activated protein C resistance (APC-R) test is described. In this method, the patient sample is prediluted in a plasma depleted of factor V (FV). A reagent containing APC and a specific activator of FV is added. After an incubation period, clotting is initiated by the additio...

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Veröffentlicht in:	American journal of clinical pathology 2004-12, Vol.122 (6), p.836-842
Hauptverfasser:	WILMER, Marianne, STOCKER, Christoph, BÜHLER, Beatrice, CONELL, Brigitte, CALATZIS, Andreas
Format:	Artikel
Sprache:	eng
Schlagworte:	Biological and medical sciences Blood Coagulation Tests - methods Factor V - analysis Factor V - genetics Factor V Deficiency - blood Hematologic and hematopoietic diseases Humans Investigative techniques, diagnostic techniques (general aspects) Medical sciences Mutation Pathology. Cytology. Biochemistry. Spectrometry. Miscellaneous investigative techniques Platelet diseases and coagulopathies Protein C - metabolism Prothrombin - metabolism Sensitivity and Specificity
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