Identification, Cloning, Expression, and Purification of Three Novel Human Calcium-independent Phospholipase A2 Family Members Possessing Triacylglycerol Lipase and Acylglycerol Transacylase Activities

Genetic knockout of hormone-sensitive lipase in mice has implicated the presence of other intracellular triacylglycerol (TAG) lipases mediating TAG hydrolysis in adipocytes. Despite intense interest in these TAG lipases, their molecular identities thus far are largely unknown. Sequence data base sea...

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Veröffentlicht in:	The Journal of biological chemistry 2004-11, Vol.279 (47), p.48968-48975
Hauptverfasser:	Jenkins, Christopher M, Mancuso, David J, Yan, Wei, Sims, Harold F, Gibson, Beverly, Gross, Richard W
Format:	Artikel
Sprache:	eng
Schlagworte:	3T3-L1 Cells Acyltransferases - metabolism Adipocytes - metabolism Amino Acid Motifs Amino Acid Sequence Animals Blotting, Western Calcium - metabolism Catalysis Cell Line Chromatography Cloning, Molecular Cytosol - metabolism Databases as Topic Diacylglycerol O-Acyltransferase Diglycerides - pharmacology DNA, Complementary - metabolism Electrophoresis, Polyacrylamide Gel Group VI Phospholipases A2 Humans Hydrolysis Insecta Lipase - metabolism Lipid Metabolism Liposarcoma - metabolism Membrane Proteins - chemistry Membrane Proteins - genetics Mice Molecular Sequence Data Naphthalenes - pharmacology Phosphodiesterase Inhibitors - pharmacology Phospholipases A - chemistry Phospholipases A - genetics Phospholipases A2 Polymerase Chain Reaction Protein Isoforms Proteins - chemistry Proteins - genetics Pyrones - pharmacology Recombinant Proteins - chemistry Sequence Homology, Amino Acid Subcellular Fractions Time Factors Triolein - pharmacology
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