Effects of local administration of clodronate on orthodontic tooth movement and root resorption in rats
Clodronate, a non-N-containing bisphosphonate, strongly inhibits bone resorption and also has anti-inflammatory properties. The purpose of this study was to examine the effect of the local administration of clodronate on orthodontic tooth movement. Both the right and left upper first molars of 26 7-...
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| Veröffentlicht in: | European journal of orthodontics 2004-10, Vol.26 (5), p.469-473 |
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| container_end_page | 473 |
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| container_issue | 5 |
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| container_title | European journal of orthodontics |
| container_volume | 26 |
| creator | Liu, Lin Igarashi, Kaoru Haruyama, Naoto Saeki, Shuichi Shinoda, Hisashi Mitani, Hideo |
| description | Clodronate, a non-N-containing bisphosphonate, strongly inhibits bone resorption and also has anti-inflammatory properties. The purpose of this study was to examine the effect of the local administration of clodronate on orthodontic tooth movement. Both the right and left upper first molars of 26 7-week-old male Wistar rats were moved buccally with a standardized expansion spring. Clodronate solution was injected into the sub-periosteum area adjacent to the left upper molar every third day during the experimental period. The right first molar served as the control. Local injection of clodronate caused a significant (P < 0.001) and dose-dependent reduction in tooth movement in the rats. The number of osteoclasts on the clodronate-injected side was significantly less (P < 0.01) than on the control side. Local clodronate also inhibited root resorption incident to tooth movement. These results suggest that localized use of clodronate could be a useful therapeutic adjunct in orthodontic treatment. |
| doi_str_mv | 10.1093/ejo/26.5.469 |
| format | Article |
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The purpose of this study was to examine the effect of the local administration of clodronate on orthodontic tooth movement. Both the right and left upper first molars of 26 7-week-old male Wistar rats were moved buccally with a standardized expansion spring. Clodronate solution was injected into the sub-periosteum area adjacent to the left upper molar every third day during the experimental period. The right first molar served as the control. Local injection of clodronate caused a significant (P < 0.001) and dose-dependent reduction in tooth movement in the rats. The number of osteoclasts on the clodronate-injected side was significantly less (P < 0.01) than on the control side. Local clodronate also inhibited root resorption incident to tooth movement. These results suggest that localized use of clodronate could be a useful therapeutic adjunct in orthodontic treatment.</description><identifier>ISSN: 0141-5387</identifier><identifier>EISSN: 1460-2210</identifier><identifier>DOI: 10.1093/ejo/26.5.469</identifier><identifier>PMID: 15536834</identifier><identifier>CODEN: EJOODK</identifier><language>eng</language><publisher>England: Oxford University Press</publisher><subject>Alveolar Process - drug effects ; Animals ; Clodronic Acid - pharmacology ; Dentistry ; Male ; Osteoclasts - drug effects ; Rats ; Rats, Wistar ; Root Resorption - drug therapy ; Tooth Movement Techniques</subject><ispartof>European journal of orthodontics, 2004-10, Vol.26 (5), p.469-473</ispartof><rights>Copyright Oxford University Press(England) Oct 2004</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c489t-a81df3f50c9308058868bc69503b32a0bc9d1d679c6fedecad02a5b221b63c703</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/15536834$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Liu, Lin</creatorcontrib><creatorcontrib>Igarashi, Kaoru</creatorcontrib><creatorcontrib>Haruyama, Naoto</creatorcontrib><creatorcontrib>Saeki, Shuichi</creatorcontrib><creatorcontrib>Shinoda, Hisashi</creatorcontrib><creatorcontrib>Mitani, Hideo</creatorcontrib><title>Effects of local administration of clodronate on orthodontic tooth movement and root resorption in rats</title><title>European journal of orthodontics</title><addtitle>Eur J Orthod</addtitle><description>Clodronate, a non-N-containing bisphosphonate, strongly inhibits bone resorption and also has anti-inflammatory properties. 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These results suggest that localized use of clodronate could be a useful therapeutic adjunct in orthodontic treatment.</description><subject>Alveolar Process - drug effects</subject><subject>Animals</subject><subject>Clodronic Acid - pharmacology</subject><subject>Dentistry</subject><subject>Male</subject><subject>Osteoclasts - drug effects</subject><subject>Rats</subject><subject>Rats, Wistar</subject><subject>Root Resorption - drug therapy</subject><subject>Tooth Movement Techniques</subject><issn>0141-5387</issn><issn>1460-2210</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2004</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkUFrFDEYhkOp2LV661lCD56c7ZdkkkmOZWmtUPCgguwlZJJMO-tMsk2yov_erLtU8OIp8Ob5Xnh5ELogsCSg2JXfxCsqlnzZCnWCFqQV0FBK4BQtgLSk4Ux2Z-hVzhsAYLLtXqIzwjkTkrUL9HAzDN6WjOOAp2jNhI2bxzDmkkwZY9jndoouxWCKx_sglcfoYiijxSXG8ojn-MPPPhRsgsOpRjj5HNP2z_0YcG3Kr9GLwUzZvzm-5-jr7c2X1V1z_-nDx9X1fWNbqUpjJHEDGzhYxUACl1LI3grFgfWMGuitcsSJTlkxeOetcUAN7-veXjDbATtH7w692xSfdj4XPY_Z-mkywcdd1qIDoYD8H6TAiaJUVfDyH3ATdynUEZWRiitB2gq9P0A2xZyTH_Q2jbNJvzQBvdekqyZNhea6aqr422Pnrp-9-wsfvVSgOQBVhP_5_G_S97qAdVzffVtrQdefV-yW6TX7DZwxngQ</recordid><startdate>20041001</startdate><enddate>20041001</enddate><creator>Liu, Lin</creator><creator>Igarashi, Kaoru</creator><creator>Haruyama, Naoto</creator><creator>Saeki, Shuichi</creator><creator>Shinoda, Hisashi</creator><creator>Mitani, Hideo</creator><general>Oxford University Press</general><general>Oxford Publishing Limited (England)</general><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QP</scope><scope>K9.</scope><scope>7X8</scope></search><sort><creationdate>20041001</creationdate><title>Effects of local administration of clodronate on orthodontic tooth movement and root resorption in rats</title><author>Liu, Lin ; Igarashi, Kaoru ; Haruyama, Naoto ; Saeki, Shuichi ; Shinoda, Hisashi ; Mitani, Hideo</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c489t-a81df3f50c9308058868bc69503b32a0bc9d1d679c6fedecad02a5b221b63c703</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2004</creationdate><topic>Alveolar Process - drug effects</topic><topic>Animals</topic><topic>Clodronic Acid - pharmacology</topic><topic>Dentistry</topic><topic>Male</topic><topic>Osteoclasts - drug effects</topic><topic>Rats</topic><topic>Rats, Wistar</topic><topic>Root Resorption - drug therapy</topic><topic>Tooth Movement Techniques</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Liu, Lin</creatorcontrib><creatorcontrib>Igarashi, Kaoru</creatorcontrib><creatorcontrib>Haruyama, Naoto</creatorcontrib><creatorcontrib>Saeki, Shuichi</creatorcontrib><creatorcontrib>Shinoda, Hisashi</creatorcontrib><creatorcontrib>Mitani, Hideo</creatorcontrib><collection>Istex</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>MEDLINE - Academic</collection><jtitle>European journal of orthodontics</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Liu, Lin</au><au>Igarashi, Kaoru</au><au>Haruyama, Naoto</au><au>Saeki, Shuichi</au><au>Shinoda, Hisashi</au><au>Mitani, Hideo</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Effects of local administration of clodronate on orthodontic tooth movement and root resorption in rats</atitle><jtitle>European journal of orthodontics</jtitle><addtitle>Eur J Orthod</addtitle><date>2004-10-01</date><risdate>2004</risdate><volume>26</volume><issue>5</issue><spage>469</spage><epage>473</epage><pages>469-473</pages><issn>0141-5387</issn><eissn>1460-2210</eissn><coden>EJOODK</coden><abstract>Clodronate, a non-N-containing bisphosphonate, strongly inhibits bone resorption and also has anti-inflammatory properties. The purpose of this study was to examine the effect of the local administration of clodronate on orthodontic tooth movement. Both the right and left upper first molars of 26 7-week-old male Wistar rats were moved buccally with a standardized expansion spring. Clodronate solution was injected into the sub-periosteum area adjacent to the left upper molar every third day during the experimental period. The right first molar served as the control. Local injection of clodronate caused a significant (P < 0.001) and dose-dependent reduction in tooth movement in the rats. The number of osteoclasts on the clodronate-injected side was significantly less (P < 0.01) than on the control side. Local clodronate also inhibited root resorption incident to tooth movement. These results suggest that localized use of clodronate could be a useful therapeutic adjunct in orthodontic treatment.</abstract><cop>England</cop><pub>Oxford University Press</pub><pmid>15536834</pmid><doi>10.1093/ejo/26.5.469</doi><tpages>5</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | European journal of orthodontics, 2004-10, Vol.26 (5), p.469-473 |
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| language | eng |
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| source | MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; Oxford University Press Journals All Titles (1996-Current) |
| subjects | Alveolar Process - drug effects Animals Clodronic Acid - pharmacology Dentistry Male Osteoclasts - drug effects Rats Rats, Wistar Root Resorption - drug therapy Tooth Movement Techniques |
| title | Effects of local administration of clodronate on orthodontic tooth movement and root resorption in rats |
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