Thrombospondin Induces RhoA Inactivation through FAK-dependent Signaling to Stimulate Focal Adhesion Disassembly

Cells utilize dynamic interactions with the extracellular matrix to adapt to changing environmental conditions. Thrombospondin 1 (TSP1) induces focal adhesion disassembly and cell migration through a sequence (hep I) in its heparin-binding domain signaling through the calreticulin-low density lipopr...

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Veröffentlicht in:	The Journal of biological chemistry 2004-11, Vol.279 (47), p.48983-48992
Hauptverfasser:	Orr, Anthony Wayne, Pallero, Manuel Antonio, Xiong, Wen-Cheng, Murphy-Ullrich, Joanne E.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Blood Platelets - metabolism Calreticulin - metabolism Cattle Cell Movement Cells, Cultured Dimerization Endothelium, Vascular - metabolism Enzyme Activation Enzyme Inhibitors - pharmacology Fibroblasts - metabolism Focal Adhesion Kinase 1 Focal Adhesion Protein-Tyrosine Kinases GTP-Binding Protein alpha Subunit, Gi2 GTP-Binding Protein alpha Subunits, Gi-Go - metabolism Humans Immunoblotting Immunoprecipitation Kinetics Microscopy, Fluorescence Mitogen-Activated Protein Kinase 3 - metabolism Models, Biological Phosphatidylinositol 3-Kinases - metabolism Phosphorylation Protein Structure, Tertiary Protein-Tyrosine Kinases - metabolism Proto-Oncogene Proteins - metabolism rhoA GTP-Binding Protein - metabolism Signal Transduction Thrombospondins - physiology Time Factors Transfection
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