Cyclosporin A Inhibits Flow-mediated Activation of Endothelial Nitric-oxide Synthase by Altering Cholesterol Content in Caveolae

Fluid shear stress generated by blood flowing over the endothelium is a major determinant of arterial tone, vascular remodeling, and atherogenesis. Nitric oxide (NO) produced by endothelial NO synthase (eNOS) plays an essential role in regulation of vascular function and structure by blood flow. Alt...

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Veröffentlicht in:	The Journal of biological chemistry 2004-11, Vol.279 (47), p.48794-48800
Hauptverfasser:	Lungu, Andreea O, Jin, Zheng-Gen, Yamawaki, Hideyuki, Tanimoto, Tatsuo, Wong, Chelsea, Berk, Bradford C
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenoviridae - genetics Animals Aorta - metabolism beta-Cyclodextrins - pharmacology Blotting, Western Cattle Cell Membrane - metabolism Cells, Cultured Cholesterol - metabolism Cyclic AMP-Dependent Protein Kinases - chemistry Cyclosporine - pharmacology Detergents - pharmacology Endothelium, Vascular - enzymology Endothelium, Vascular - metabolism Enzyme Activation Immunoblotting Immunosuppressive Agents - pharmacology Kinetics Nitric Oxide - metabolism Nitric Oxide Synthase - metabolism Nitric Oxide Synthase Type III Phosphorylation Protein-Serine-Threonine Kinases - chemistry Proto-Oncogene Proteins - chemistry Proto-Oncogene Proteins c-akt Rabbits Serine - chemistry Stress, Mechanical Time Factors
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