Sterol-responsive element-binding protein (SREBP) 2 down-regulates ATP-binding cassette transporter A1 in vascular endothelial cells: a novel role of SREBP in regulating cholesterol metabolism

ATP-binding cassette transporter A1 (ABCA1) is a pivotal regulator of cholesterol efflux from cells to apolipoproteins, whereas sterol-responsive element-binding protein 2 (SREBP2) is the key protein regulating cholesterol synthesis and uptake. We investigated the regulation of ABCA1 by SREBP2 in va...

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Veröffentlicht in:	The Journal of biological chemistry 2004-11, Vol.279 (47), p.48801-48807
Hauptverfasser:	Zeng, Lingfang, Liao, Hailing, Liu, Yi, Lee, Tzong-Shyuan, Zhu, Minjia, Wang, Xian, Stemerman, Michael B, Zhu, Yi, Shyy, John Y-J
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenosine Triphosphate - metabolism Adenoviridae - genetics ATP Binding Cassette Transporter 1 ATP-Binding Cassette Transporters - metabolism Blotting, Northern Blotting, Western Cells, Cultured Cholesterol - metabolism Chromatin Immunoprecipitation DNA-Binding Proteins - metabolism DNA-Binding Proteins - physiology Down-Regulation Endothelium, Vascular - cytology Endothelium, Vascular - metabolism Humans Mutation Oscillometry Plasmids - metabolism Promoter Regions, Genetic Protein Binding Protein Structure, Tertiary Receptors, LDL - metabolism Reverse Transcriptase Polymerase Chain Reaction RNA, Messenger - metabolism Sterol Regulatory Element Binding Protein 2 Sterols - metabolism Time Factors Transcription Factors - metabolism Transcription Factors - physiology Transcription, Genetic Transfection Umbilical Veins - cytology
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