Severe disease expression of cardiac troponin C and T mutations in patients with idiopathic dilated cardiomyopathy

We performed genetic investigations of cardiac troponin T (TNNT2) and troponin C (TNNC1) in 235 consecutive patients with idiopathic dilated cardiomyopathy (DCM) to evaluate prevalence of mutations and associated disease expression in affected families. Recently, mutations in sarcomeric genes have b...

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Veröffentlicht in:	Journal of the American College of Cardiology 2004-11, Vol.44 (10), p.2033-2040
Hauptverfasser:	Mogensen, Jens, Murphy, Ross T., Shaw, Tony, Bahl, Ajay, Redwood, Charles, Watkins, Hugh, Burke, Margaret, Elliott, Perry M., McKenna, William J.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adolescent Adult Age Amino acids Cardiology Cardiomyopathy Cardiomyopathy, Dilated - blood Cardiomyopathy, Dilated - diagnostic imaging Cardiomyopathy, Dilated - genetics Cardiomyopathy, Dilated - pathology Cloning Cohort Studies Deoxyribonucleic acid DNA Echocardiography England - epidemiology Female Heart failure Humans Male Middle Aged Mutation Pedigree Prevalence Proteins Severity of Illness Index Studies Troponin C - genetics Troponin T - genetics Values
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