Splenic rupture in a parental donor undergoing peripheral blood progenitor cell mobilization
Peripheral blood progenitor cells (PBPCs) are now widely used as a source of progenitor cells for allogeneic transplantation. Recombinant human granulocyte colony-stimulating factor is used to mobilize PBPCs for collection by leukapheresis. Although side effects of mobilization are generally benign,...
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| Veröffentlicht in: | Journal of pediatric hematology/oncology 2004-11, Vol.26 (11), p.761-763 |
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| container_end_page | 763 |
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| container_issue | 11 |
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| container_title | Journal of pediatric hematology/oncology |
| container_volume | 26 |
| creator | Dincer, Ayse P Gottschall, Jerome Margolis, David A |
| description | Peripheral blood progenitor cells (PBPCs) are now widely used as a source of progenitor cells for allogeneic transplantation. Recombinant human granulocyte colony-stimulating factor is used to mobilize PBPCs for collection by leukapheresis. Although side effects of mobilization are generally benign, adverse effects have been reported. The authors present a case of spontaneous splenic rupture, without splenomegaly, in a parental donor undergoing PBPC mobilization, review the literature regarding this adverse event, and explore issues regarding donor safety. |
| doi_str_mv | 10.1097/00043426-200411000-00015 |
| format | Article |
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Recombinant human granulocyte colony-stimulating factor is used to mobilize PBPCs for collection by leukapheresis. Although side effects of mobilization are generally benign, adverse effects have been reported. 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| fulltext | fulltext |
| identifier | ISSN: 1077-4114 |
| ispartof | Journal of pediatric hematology/oncology, 2004-11, Vol.26 (11), p.761-763 |
| issn | 1077-4114 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_67067358 |
| source | MEDLINE; Journals@Ovid Complete |
| subjects | Adult Granulocyte Colony-Stimulating Factor - adverse effects Hematopoietic Stem Cell Mobilization - adverse effects Humans Male Parents Peripheral Blood Stem Cell Transplantation Spleen - blood supply Spleen - pathology Splenic Rupture - etiology Tissue Donors |
| title | Splenic rupture in a parental donor undergoing peripheral blood progenitor cell mobilization |
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