Systemic and Peritoneal Angiogenic Response After Laparoscopic or Conventional Colon Resection in Cancer Patients: A Prospective, Randomized Trial
Angiogenesis is essential for wound healing. Vascular endothelial growth factor and endostatin are both endogenous angiogenic factors thought to be involved in the initiation and termination of angiogenesis. The aim of this study was to assess the local and systemic angiogenic profile in patients un...
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| Veröffentlicht in: | Diseases of the colon & rectum 2004-10, Vol.47 (10), p.1670-1674 |
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| container_title | Diseases of the colon & rectum |
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| creator | Wu, F P. K Hoekman, K Sietses, C von Blomberg, B M. E Meijer, S Bonjer, H J Cuesta, M A |
| description | Angiogenesis is essential for wound healing. Vascular endothelial growth factor and endostatin are both endogenous angiogenic factors thought to be involved in the initiation and termination of angiogenesis. The aim of this study was to assess the local and systemic angiogenic profile in patients undergoing laparoscopic or open surgery for colon cancer.
Patients with primary colon carcinoma were prospectively randomized to curative laparoscopic (n = 12) or conventional (n = 14) resection. Vascular endothelial growth factor and endostatin levels in serum and wound fluid were investigated.
In both groups vascular endothelial growth factor levels in wound fluid were significantly higher than postoperative serum levels, whereas endostatin levels in wound fluid were lower than serum levels and decreased progressively after surgery. The vascular endothelial growth factor levels in wound fluid measured at Day 4 were significantly higher in the laparoscopy group than in the laparotomy patients.
Wound healing is associated with a strong local increase in pro-angiogenic factors and a decrease in antiangiogenic factors. The investigation of locally produced factors offered greater insight into the process of angiogenesis during wound healing than could be acquired from the circulation. |
| doi_str_mv | 10.1007/s10350-004-0660-6 |
| format | Article |
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Patients with primary colon carcinoma were prospectively randomized to curative laparoscopic (n = 12) or conventional (n = 14) resection. Vascular endothelial growth factor and endostatin levels in serum and wound fluid were investigated.
In both groups vascular endothelial growth factor levels in wound fluid were significantly higher than postoperative serum levels, whereas endostatin levels in wound fluid were lower than serum levels and decreased progressively after surgery. The vascular endothelial growth factor levels in wound fluid measured at Day 4 were significantly higher in the laparoscopy group than in the laparotomy patients.
Wound healing is associated with a strong local increase in pro-angiogenic factors and a decrease in antiangiogenic factors. The investigation of locally produced factors offered greater insight into the process of angiogenesis during wound healing than could be acquired from the circulation.</description><identifier>ISSN: 0012-3706</identifier><identifier>EISSN: 1530-0358</identifier><identifier>DOI: 10.1007/s10350-004-0660-6</identifier><identifier>PMID: 15540297</identifier><identifier>CODEN: DICRAG</identifier><language>eng</language><publisher>Secaucus, NJ: The ASCRS</publisher><subject>Aged ; Biological and medical sciences ; Colonic Neoplasms - surgery ; Endostatins - blood ; Female ; Gastroenterology. Liver. Pancreas. Abdomen ; Humans ; Laparoscopy ; Laparotomy ; Male ; Medical sciences ; Middle Aged ; Neovascularization, Physiologic ; Prospective Studies ; Stomach. Duodenum. Small intestine. Colon. Rectum. Anus ; Tumors ; Vascular Endothelial Growth Factor A - blood ; Wound Healing</subject><ispartof>Diseases of the colon & rectum, 2004-10, Vol.47 (10), p.1670-1674</ispartof><rights>The ASCRS 2004</rights><rights>2004 INIST-CNRS</rights><rights>Copyright Springer-Verlag 2004</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3995-cd33556884f0397b7e48e84cec15c06a9ec01587a42a14a2db936b21ce4ad7193</citedby><cites>FETCH-LOGICAL-c3995-cd33556884f0397b7e48e84cec15c06a9ec01587a42a14a2db936b21ce4ad7193</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27901,27902</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=16245243$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/15540297$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Wu, F P. K</creatorcontrib><creatorcontrib>Hoekman, K</creatorcontrib><creatorcontrib>Sietses, C</creatorcontrib><creatorcontrib>von Blomberg, B M. E</creatorcontrib><creatorcontrib>Meijer, S</creatorcontrib><creatorcontrib>Bonjer, H J</creatorcontrib><creatorcontrib>Cuesta, M A</creatorcontrib><title>Systemic and Peritoneal Angiogenic Response After Laparoscopic or Conventional Colon Resection in Cancer Patients: A Prospective, Randomized Trial</title><title>Diseases of the colon & rectum</title><addtitle>Dis Colon Rectum</addtitle><description>Angiogenesis is essential for wound healing. Vascular endothelial growth factor and endostatin are both endogenous angiogenic factors thought to be involved in the initiation and termination of angiogenesis. The aim of this study was to assess the local and systemic angiogenic profile in patients undergoing laparoscopic or open surgery for colon cancer.
Patients with primary colon carcinoma were prospectively randomized to curative laparoscopic (n = 12) or conventional (n = 14) resection. Vascular endothelial growth factor and endostatin levels in serum and wound fluid were investigated.
In both groups vascular endothelial growth factor levels in wound fluid were significantly higher than postoperative serum levels, whereas endostatin levels in wound fluid were lower than serum levels and decreased progressively after surgery. The vascular endothelial growth factor levels in wound fluid measured at Day 4 were significantly higher in the laparoscopy group than in the laparotomy patients.
Wound healing is associated with a strong local increase in pro-angiogenic factors and a decrease in antiangiogenic factors. The investigation of locally produced factors offered greater insight into the process of angiogenesis during wound healing than could be acquired from the circulation.</description><subject>Aged</subject><subject>Biological and medical sciences</subject><subject>Colonic Neoplasms - surgery</subject><subject>Endostatins - blood</subject><subject>Female</subject><subject>Gastroenterology. Liver. Pancreas. Abdomen</subject><subject>Humans</subject><subject>Laparoscopy</subject><subject>Laparotomy</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Neovascularization, Physiologic</subject><subject>Prospective Studies</subject><subject>Stomach. Duodenum. Small intestine. Colon. Rectum. 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E ; Meijer, S ; Bonjer, H J ; Cuesta, M A</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3995-cd33556884f0397b7e48e84cec15c06a9ec01587a42a14a2db936b21ce4ad7193</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2004</creationdate><topic>Aged</topic><topic>Biological and medical sciences</topic><topic>Colonic Neoplasms - surgery</topic><topic>Endostatins - blood</topic><topic>Female</topic><topic>Gastroenterology. Liver. Pancreas. Abdomen</topic><topic>Humans</topic><topic>Laparoscopy</topic><topic>Laparotomy</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Neovascularization, Physiologic</topic><topic>Prospective Studies</topic><topic>Stomach. Duodenum. Small intestine. Colon. Rectum. Anus</topic><topic>Tumors</topic><topic>Vascular Endothelial Growth Factor A - blood</topic><topic>Wound Healing</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Wu, F P. K</creatorcontrib><creatorcontrib>Hoekman, K</creatorcontrib><creatorcontrib>Sietses, C</creatorcontrib><creatorcontrib>von Blomberg, B M. 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Patients with primary colon carcinoma were prospectively randomized to curative laparoscopic (n = 12) or conventional (n = 14) resection. Vascular endothelial growth factor and endostatin levels in serum and wound fluid were investigated.
In both groups vascular endothelial growth factor levels in wound fluid were significantly higher than postoperative serum levels, whereas endostatin levels in wound fluid were lower than serum levels and decreased progressively after surgery. The vascular endothelial growth factor levels in wound fluid measured at Day 4 were significantly higher in the laparoscopy group than in the laparotomy patients.
Wound healing is associated with a strong local increase in pro-angiogenic factors and a decrease in antiangiogenic factors. The investigation of locally produced factors offered greater insight into the process of angiogenesis during wound healing than could be acquired from the circulation.</abstract><cop>Secaucus, NJ</cop><pub>The ASCRS</pub><pmid>15540297</pmid><doi>10.1007/s10350-004-0660-6</doi><tpages>5</tpages></addata></record> |
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| identifier | ISSN: 0012-3706 |
| ispartof | Diseases of the colon & rectum, 2004-10, Vol.47 (10), p.1670-1674 |
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| source | Journals@Ovid Ovid Autoload; MEDLINE; SpringerLink Journals |
| subjects | Aged Biological and medical sciences Colonic Neoplasms - surgery Endostatins - blood Female Gastroenterology. Liver. Pancreas. Abdomen Humans Laparoscopy Laparotomy Male Medical sciences Middle Aged Neovascularization, Physiologic Prospective Studies Stomach. Duodenum. Small intestine. Colon. Rectum. Anus Tumors Vascular Endothelial Growth Factor A - blood Wound Healing |
| title | Systemic and Peritoneal Angiogenic Response After Laparoscopic or Conventional Colon Resection in Cancer Patients: A Prospective, Randomized Trial |
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