A Fluorescent Probe of Polyamine Transport Accumulates into Intracellular Acidic Vesicles via a Two-step Mechanism

Mammalian polyamine carriers have not yet been molecularly identified. The fluoroprobe Spd-C 2 -BODIPY faithfully reports polyamine transport and accumulates almost exclusively in polyamine-sequestering vesicles (PSVs). Polyamines might thus be imported first by a plasma membrane carrier and then se...

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Veröffentlicht in:	The Journal of biological chemistry 2004-11, Vol.279 (47), p.49355-49366
Hauptverfasser:	Soulet, Denis, Gagnon, Bruno, Rivest, Serge, Audette, Marie, Poulin, Richard
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biological Transport Boron Compounds - pharmacology CHO Cells Cricetinae Endocytosis Endosomes - metabolism Fluorescent Dyes - pharmacology Golgi Apparatus - metabolism Image Processing, Computer-Assisted Lysosomes - metabolism Macrolides - pharmacology Microscopy, Confocal Microscopy, Fluorescence Models, Biological Models, Chemical Monensin - metabolism Mutation Polyamines - chemistry Protons Spermidine - analogs & derivatives Spermidine - pharmacology Time Factors Vacuolar Proton-Translocating ATPases - chemistry
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