Mitochondrial and nuclear DNA damage induced by 5-aminolevulinic acid

5-Aminolevulinic acid (ALA) is a heme precursor accumulated in plasma and in organs in acute intermittent porphyria (AIP), a disease associated with neuromuscular dysfunction and increased incidence of hepatocellular carcinoma (HCC). Liver biopsies of AIP patients showed odd-shaped mitochondria and...

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Veröffentlicht in:	Archives of biochemistry and biophysics 2004-12, Vol.432 (2), p.178-187
Hauptverfasser:	Onuki, Janice, Chen, Yiming, Teixeira, Priscila C., Schumacher, Robert I., Medeiros, Marisa H.G., Van Houten, Bennett, Di Mascio, Paolo
Format:	Artikel
Sprache:	eng
Schlagworte:	5-Aminolevulinic acid Acute intermittent porphyria Aminolevulinic Acid - pharmacology Animals Apoptosis - drug effects Cell Line Cell Nucleus - drug effects Cell Nucleus - ultrastructure Cell Survival - drug effects CHO Cells Cricetinae DNA - drug effects DNA - ultrastructure DNA Damage Dose-Response Relationship, Drug Fibroblasts - drug effects Fibroblasts - ultrastructure Hepatocellular carcinoma Hepatocytes - drug effects Hepatocytes - ultrastructure Humans Mitochondria - drug effects Mitochondria - physiology Mitochondria - ultrastructure Mitochondrial DNA damage PC12 Cells Quantitative polymerase chain reaction Rats
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