TNF-α antibodies and osteoprotegerin decrease systemic bone loss associated with inflammation through distinct mechanisms in collagen-induced arthritis

Introduction: Rheumatoid arthritis (RA) is associated with focal and systemic bone loss involving cytokines such as RANKL and TNF-α. RANK-L promotes focal and systemic osteoporosis, whereas osteoprotegerin (OPG) inhibits bone resorption. Although anti-TNF-α antibodies (anti-TNF-α Ab) decrease joint...

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Veröffentlicht in:	Bone (New York, N.Y.) N.Y.), 2004-11, Vol.35 (5), p.1200-1207
Hauptverfasser:	Saidenberg-Kermanac'h, N., Corrado, A., Lemeiter, D., deVernejoul, M.C., Boissier, M.C., Cohen-Solal, M.E.
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acids - urine Animals Anti-TNF-α Antibodies - immunology Antibodies - pharmacology Arthritis, Experimental - complications Arthritis, Experimental - drug therapy Arthritis, Experimental - pathology Biological and medical sciences Bone Density - drug effects Bone loss Bone Resorption - drug therapy Bone Resorption - etiology Collagen-induced arthritis Diseases of the osteoarticular system Femur - chemistry Femur - drug effects Femur - pathology Glycoproteins - pharmacology Inflammation - complications Inflammation - drug therapy Inflammatory joint diseases Male Medical sciences Mice Mice, Inbred DBA Osteogenesis - drug effects Osteoprotegerin Receptors, Cytoplasmic and Nuclear Receptors, Tumor Necrosis Factor Tumor Necrosis Factor-alpha - antagonists & inhibitors Tumor Necrosis Factor-alpha - immunology
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