An improved method for detection of replication-competent retrovirus in retrovirus vector products

Contamination by replication-competent retrovirus (RCR) is one of the most important safety issues of retrovirus vector products for gene therapy clinical research. To improve the sensitivity of RCR detection and to shorten the assay period, we have developed a novel RCR detection method (infectivit...

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Veröffentlicht in:	Biologicals 2004-09, Vol.32 (3), p.139-146
Hauptverfasser:	Uchida, Eriko, Sato, Koei, Iwata, Akiko, Ishii-Watabe, Akiko, Mizuguchi, Hiroyuki, Hikata, Mikio, Murata, Mitsuhiro, Yamaguchi, Teruhide, Hayakawa, Takao
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Cats Cell Line Consumer Product Safety Genetic Vectors - analysis Humans Mice Moloney murine leukemia virus Reverse Transcriptase Polymerase Chain Reaction - methods Tumor Virus Infections - prevention & control Virus Replication
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