Educational Level Influences Regional Cerebral Blood Flow in Patients with Alzheimer's Disease
We tested the hypothesis that educational level influences regional cerebral blood flow (rCBF) in Alzheimer's disease (AD) patients. The severity of AD was measured with the Cognitive Ability Screening Instrument (age and education adjusted). rCBF was assessed using (99m)Tc-hexamethylpropylenea...
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| Veröffentlicht in: | The Journal of nuclear medicine (1978) 2004-11, Vol.45 (11), p.1860-1863 |
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| container_title | The Journal of nuclear medicine (1978) |
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| creator | Chiu, Nan-Tsing Lee, Bi-Fang Hsiao, Sigmund Pai, Ming-Chyi |
| description | We tested the hypothesis that educational level influences regional cerebral blood flow (rCBF) in Alzheimer's disease (AD) patients.
The severity of AD was measured with the Cognitive Ability Screening Instrument (age and education adjusted). rCBF was assessed using (99m)Tc-hexamethylpropyleneamine oxime brain SPECT; differences in rCBF between groups with different educational levels were determined using statistical parametric mapping (SPM).
In matched low-education (< or =6 y; n = 29) and high-education (>6 y; n = 29) groups, SPM revealed 2 statistically significant clusters of voxels with higher rCBF in the high-education group: one in the left lateral inferior, middle, and superior temporal gyrus; another in the left medial temporal area to the left inferior frontal gyrus.
We provide biologic evidence that education may lead to relatively higher rCBF in specific areas in AD patients, which may explain the effects of education on clinical manifestations of AD. |
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The severity of AD was measured with the Cognitive Ability Screening Instrument (age and education adjusted). rCBF was assessed using (99m)Tc-hexamethylpropyleneamine oxime brain SPECT; differences in rCBF between groups with different educational levels were determined using statistical parametric mapping (SPM).
In matched low-education (< or =6 y; n = 29) and high-education (>6 y; n = 29) groups, SPM revealed 2 statistically significant clusters of voxels with higher rCBF in the high-education group: one in the left lateral inferior, middle, and superior temporal gyrus; another in the left medial temporal area to the left inferior frontal gyrus.
We provide biologic evidence that education may lead to relatively higher rCBF in specific areas in AD patients, which may explain the effects of education on clinical manifestations of AD.</description><identifier>ISSN: 0161-5505</identifier><identifier>EISSN: 1535-5667</identifier><identifier>PMID: 15534055</identifier><identifier>CODEN: JNMEAQ</identifier><language>eng</language><publisher>United States: Soc Nuclear Med</publisher><subject>Aged ; Alzheimer Disease - diagnostic imaging ; Alzheimer Disease - epidemiology ; Alzheimer Disease - physiopathology ; Brain - blood supply ; Brain - diagnostic imaging ; Cerebrovascular Circulation ; Educational Status ; Female ; Humans ; Male ; Radionuclide Imaging ; Risk Assessment - methods ; Risk Factors ; Statistics as Topic ; Taiwan - epidemiology</subject><ispartof>The Journal of nuclear medicine (1978), 2004-11, Vol.45 (11), p.1860-1863</ispartof><rights>Copyright Society of Nuclear Medicine Nov 2004</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/15534055$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Chiu, Nan-Tsing</creatorcontrib><creatorcontrib>Lee, Bi-Fang</creatorcontrib><creatorcontrib>Hsiao, Sigmund</creatorcontrib><creatorcontrib>Pai, Ming-Chyi</creatorcontrib><title>Educational Level Influences Regional Cerebral Blood Flow in Patients with Alzheimer's Disease</title><title>The Journal of nuclear medicine (1978)</title><addtitle>J Nucl Med</addtitle><description>We tested the hypothesis that educational level influences regional cerebral blood flow (rCBF) in Alzheimer's disease (AD) patients.
The severity of AD was measured with the Cognitive Ability Screening Instrument (age and education adjusted). rCBF was assessed using (99m)Tc-hexamethylpropyleneamine oxime brain SPECT; differences in rCBF between groups with different educational levels were determined using statistical parametric mapping (SPM).
In matched low-education (< or =6 y; n = 29) and high-education (>6 y; n = 29) groups, SPM revealed 2 statistically significant clusters of voxels with higher rCBF in the high-education group: one in the left lateral inferior, middle, and superior temporal gyrus; another in the left medial temporal area to the left inferior frontal gyrus.
We provide biologic evidence that education may lead to relatively higher rCBF in specific areas in AD patients, which may explain the effects of education on clinical manifestations of AD.</description><subject>Aged</subject><subject>Alzheimer Disease - diagnostic imaging</subject><subject>Alzheimer Disease - epidemiology</subject><subject>Alzheimer Disease - physiopathology</subject><subject>Brain - blood supply</subject><subject>Brain - diagnostic imaging</subject><subject>Cerebrovascular Circulation</subject><subject>Educational Status</subject><subject>Female</subject><subject>Humans</subject><subject>Male</subject><subject>Radionuclide Imaging</subject><subject>Risk Assessment - methods</subject><subject>Risk Factors</subject><subject>Statistics as Topic</subject><subject>Taiwan - epidemiology</subject><issn>0161-5505</issn><issn>1535-5667</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2004</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><recordid>eNpd0FFLwzAQB_AgipvTryDBB_WlkKRJ2jzOuelgoIi-WtL2umak6Uxah356O6YvPt3B_3cHd0doTEUsIiFlcozGhEoaCUHECJ2FsCGEyDRNT9GIChFzIsQYvc_LvtCdaZ22eAWfYPHSVbYHV0DAL7A-JDPwkPuhubNtW-KFbXfYOPw8TILrAt6ZrsZT-12DacDfBHxvAugA5-ik0jbAxW-doLfF_HX2GK2eHpaz6SqqmVRdJGKVFFXOEybLUhINPEkkLZSUvIhzBjQtGFFDrtM8TxWoklWCMp4zwlRMaTxB14e9W99-9BC6rDGhAGu1g7YPmUyIZJImA7z6Bzdt74cTQ8aoYpwovt92-Yv6vIEy23rTaP-V_b1tALcHUJt1vTMeMtcXFrTf641ruMgozWgqSfwDRGt2cQ</recordid><startdate>20041101</startdate><enddate>20041101</enddate><creator>Chiu, Nan-Tsing</creator><creator>Lee, Bi-Fang</creator><creator>Hsiao, Sigmund</creator><creator>Pai, Ming-Chyi</creator><general>Soc Nuclear Med</general><general>Society of Nuclear Medicine</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>3V.</scope><scope>4T-</scope><scope>7RV</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>88I</scope><scope>8AF</scope><scope>8AO</scope><scope>8FD</scope><scope>8FE</scope><scope>8FG</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>ARAPS</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BGLVJ</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>KB0</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M2P</scope><scope>M7P</scope><scope>M7Z</scope><scope>NAPCQ</scope><scope>P5Z</scope><scope>P62</scope><scope>P64</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>Q9U</scope><scope>S0X</scope><scope>7X8</scope></search><sort><creationdate>20041101</creationdate><title>Educational Level Influences Regional Cerebral Blood Flow in Patients with Alzheimer's Disease</title><author>Chiu, Nan-Tsing ; 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The severity of AD was measured with the Cognitive Ability Screening Instrument (age and education adjusted). rCBF was assessed using (99m)Tc-hexamethylpropyleneamine oxime brain SPECT; differences in rCBF between groups with different educational levels were determined using statistical parametric mapping (SPM).
In matched low-education (< or =6 y; n = 29) and high-education (>6 y; n = 29) groups, SPM revealed 2 statistically significant clusters of voxels with higher rCBF in the high-education group: one in the left lateral inferior, middle, and superior temporal gyrus; another in the left medial temporal area to the left inferior frontal gyrus.
We provide biologic evidence that education may lead to relatively higher rCBF in specific areas in AD patients, which may explain the effects of education on clinical manifestations of AD.</abstract><cop>United States</cop><pub>Soc Nuclear Med</pub><pmid>15534055</pmid><tpages>4</tpages></addata></record> |
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| subjects | Aged Alzheimer Disease - diagnostic imaging Alzheimer Disease - epidemiology Alzheimer Disease - physiopathology Brain - blood supply Brain - diagnostic imaging Cerebrovascular Circulation Educational Status Female Humans Male Radionuclide Imaging Risk Assessment - methods Risk Factors Statistics as Topic Taiwan - epidemiology |
| title | Educational Level Influences Regional Cerebral Blood Flow in Patients with Alzheimer's Disease |
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