Silencing T-bet Defines a Critical Role in the Differentiation of Autoreactive T Lymphocytes

As a means of developing therapies that target the pathogenic T cells in multiple sclerosis (MS) without compromising the immune system or eliciting systemic side effects, we investigated the use of T-bet-specific antisense oligonucleotides and small interfering RNAs (siRNA) to silence T-bet express...

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Veröffentlicht in:	Immunity (Cambridge, Mass.) Mass.), 2004-11, Vol.21 (5), p.719-731
Hauptverfasser:	Lovett-Racke, Amy E., Rocchini, Anne E., Choy, Judy, Northrop, Sara C., Hussain, Rehana Z., Ratts, Robert B., Sikder, Devanjan, Racke, Michael K.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Autoimmune diseases Cell Differentiation Deoxyribonucleic acid Disease DNA DNA-Binding Proteins - genetics Encephalomyelitis, Autoimmune, Experimental - immunology Encephalomyelitis, Autoimmune, Experimental - therapy Genes Interferon-gamma - genetics Interleukin-12 - pharmacology Lymphocytes Mice Oligonucleotides, Antisense - pharmacology Proteins Receptors, Interleukin - genetics Receptors, Interleukin-12 RNA, Small Interfering - pharmacology STAT1 Transcription Factor STAT4 Transcription Factor Studies T cell receptors T-Box Domain Proteins T-Lymphocytes - cytology Trans-Activators - genetics Transcription factors Transcription Factors - genetics Transcription Factors - physiology
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