NHERF (Na+/H+Exchanger Regulatory Factor) gene mutations in human breast cancer

Yeast two-hybrid screening was used to explore novel proteins that interact with a breast tumor or metastasis suppressor, SYK (spleen tyrosine kinase). The screening yielded NHERF (Na + /H + exchanger regulatory factor, also known as NHERF1 or EBP-50) that binds to the interdomain B of SYK. NHERF is...

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Veröffentlicht in:	Oncogene 2004-11, Vol.23 (53), p.8681-8687
Hauptverfasser:	Dai, Jia Le, Wang, Lei, Sahin, Aysegul A, Broemeling, Lyle D, Schutte, Mieke, Pan, Yong
Format:	Artikel
Sprache:	eng
Schlagworte:	Apoptosis Base Sequence Biological and medical sciences Breast cancer Breast carcinoma Breast Neoplasms - genetics Breast Neoplasms - metabolism Breast Neoplasms - pathology Cell Biology Cell physiology Cell transformation and carcinogenesis. Action of oncogenes and antioncogenes Conserved Sequence - genetics Disease Progression DNA methylation Enzyme Precursors - metabolism Estrogens Fundamental and applied biological sciences. Psychology Gynecology. Andrology. Obstetrics Human Genetics Humans Hydrogen Internal Medicine Intracellular Signaling Peptides and Proteins Loss of Heterozygosity - genetics Mammary gland diseases Medical sciences Medicine Medicine & Public Health Metastases Molecular and cellular biology Mutation Mutation - genetics Na+/H+-exchanging ATPase Neurofibromatosis Neurofibromatosis 2 Neurofibromin 2 Neurofibromin 2 - metabolism Oncology original-paper Phosphoproteins - chemistry Phosphoproteins - genetics Phosphoproteins - metabolism Protein Binding Protein Structure, Tertiary Protein-tyrosine kinase Protein-Tyrosine Kinases - metabolism Sodium-Hydrogen Exchangers Spleen Syk Kinase Syk protein Tumor cell lines Tumor Cells, Cultured Tumor suppressor genes Tumors
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