Anti–MSP1 Block 2 Antibodies Are Effective at Parasite Killing in an Allele-Specific Manner by Monocyte-Mediated Antibody-Dependent Cellular Inhibition

We investigated whether anti–merozoite surface protein-1 (MSP1) block 2 antibodies mediate the monocyte-dependent antibody-mediated cellular inhibition (ADCI) of Plasmodium falciparum. This study was performed because soluble molecules have been shown to trigger ADCI and because MSP1 block 2 is rele...

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Veröffentlicht in:	The Journal of infectious diseases 2009-04, Vol.199 (8), p.1151-1154
Hauptverfasser:	Galamo, Corine Demanga, Jafarshad, Ali, Blanc, Catherine, Druilhe, Pierre
Format:	Artikel
Sprache:	eng
Schlagworte:	Alleles Animals Antibodies Antibodies, Protozoan - immunology Antibody Specificity Antigens Antigens, Protozoan - immunology Enzyme-Linked Immunosorbent Assay Epitopes Erythrocytes Humans Malaria Merozoite Surface Protein 1 - immunology Merozoites Monocytes Monocytes - physiology Parasites Plasmodium falciparum Plasmodium falciparum - immunology Proteins Recombinant Proteins - immunology Schizonts
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