Impact of engagement of FcepsilonRI and CC chemokine receptor 1 on mast cell activation and motility

CC chemokines participate in the recruitment and activation of immune cells through CC chemokine receptors (CCRs). Here, we report that cross-talk between CCR1-mediated signaling pathway and FcepsilonRI-mediated signaling pathway affects degranulation positively but affects chemotaxis of mast cells...

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Veröffentlicht in:	The Journal of biological chemistry 2004-11, Vol.279 (46), p.48443-48448
Hauptverfasser:	Toda, Masako, Dawson, Maria, Nakamura, Takao, Munro, Peter M G, Richardson, Ricardo Micheler, Bailly, Maryse, Ono, Santa Jeremy
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals cdc42 GTP-Binding Protein - metabolism Cell Degranulation - physiology Cell Line, Tumor Cell Movement - physiology Chemokines, CC - immunology Enzyme Activation Humans Intracellular Signaling Peptides and Proteins Mast Cells - immunology Mast Cells - ultrastructure Protein-Serine-Threonine Kinases - antagonists & inhibitors Protein-Serine-Threonine Kinases - metabolism rac GTP-Binding Proteins - metabolism Rats Receptors, CCR1 Receptors, Chemokine - genetics Receptors, Chemokine - immunology Receptors, IgE - immunology rho GTP-Binding Proteins - antagonists & inhibitors rho GTP-Binding Proteins - metabolism rho-Associated Kinases Signal Transduction - physiology
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