Phase 1 study of HPV16-specific immunotherapy with E6E7 fusion protein and ISCOMATRIX™ adjuvant in women with cervical intraepithelial neoplasia

: Persistent infection of cervical epithelium with “high risk” human papillomavirus (HPV) results in cervical intraepithelial neoplasia (CIN) from which squamous cancer of the cervix can arise. A study was undertaken to evaluate the safety and immunogenicity of an HPV16 immunotherapeutic consisting...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Vaccine 2004-11, Vol.23 (2), p.172-181
Hauptverfasser:	Frazer, Ian H., Quinn, Michael, Nicklin, Jim L., Tan, Jeffrey, Perrin, Lew C., Ng, Peng, O’Connor, Vivienne M., White, Olivia, Wendt, Ngaire, Martin, Juliet, Crowley, Jayne M., Edwards, Stirling J., McKenzie, Andrew W., Mitchell, Susan V., Maher, Darryl W., Pearse, Martin J., Basser, Russell L.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adjuvants, Immunologic Adolescent Adult Applied microbiology Biological and medical sciences Cancer Vaccines - immunology Cancer Vaccines - therapeutic use Cellular immunity Cervical cancer Cervical intraepithelial neoplasia Cervical Intraepithelial Neoplasia - immunology Cervical Intraepithelial Neoplasia - therapy Cervical Intraepithelial Neoplasia - virology Cholesterol - therapeutic use Delayed type hypersensitivity Drug Combinations Experimental design Female Fundamental and applied biological sciences. Psychology Histology Human papillomavirus Humans Hypersensitivity Immunization Immunogenicity Immunotherapy Infections Laboratories Lymphocytes Medical sciences Microbiology Middle Aged Miscellaneous Oncogene Proteins, Viral - genetics Papillomaviridae - immunology Papillomavirus E7 Proteins Papillomavirus Infections - immunology Papillomavirus Infections - therapy Papillomavirus Infections - virology Patients Phospholipids - therapeutic use Proteins Recombinant Fusion Proteins - immunology Recombinant Fusion Proteins - therapeutic use Repressor Proteins - genetics Saponins - therapeutic use Tumors Uterine Cervical Dysplasia - immunology Uterine Cervical Dysplasia - therapy Uterine Cervical Dysplasia - virology Vaccines Vaccines, antisera, therapeutical immunoglobulins and monoclonal antibodies (general aspects) Viral load Virology
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!