Effects of venlafaxine on p90Rsk activity in rat C6-gliomas and brain

The intracellular actions of the antidepressant, venlafaxine, were studied in C6-gliomas using a phosphoproteomics approach. Long-term pre-treatment of C6-gliomas with venlafaxine followed by an acute challenge with isoproterenol (a β-adrenoceptor agonist), resulted in increased p90Rsk phosphorylati...

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Veröffentlicht in:	Neuroscience letters 2004-11, Vol.372 (1), p.99-103
Hauptverfasser:	Khawaja, Xavier Z., Storm, Stephen, Liang, Jin-Jun
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biological and medical sciences Brain - drug effects Brain - metabolism C6-glioma Cell Line, Tumor Cyclohexanols - pharmacology Dose-Response Relationship, Drug Fundamental and applied biological sciences. Psychology Glioma - metabolism Male p90Rsk Phosphoproteomics Rat brain Rats Rats, Sprague-Dawley Ribosomal Protein S6 Kinases, 90-kDa - metabolism Signal transduction Venlafaxine Hydrochloride Vertebrates: nervous system and sense organs β-Adrenergic receptors
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