Melatonin reduces experimental subarachnoid hemorrhage-induced oxidative brain damage and neurological symptoms

: Oxidative stress has detrimental effects in several models of neurodegenerative diseases, including subarachnoid hemorrhage (SAH). This study investigated the putative neuroprotective effect of melatonin, a powerful antioxidant, in a rat model of SAH. Male Wistar albino rats were divided as contr...

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Veröffentlicht in:	Journal of pineal research 2009-04, Vol.46 (3), p.324-332
Hauptverfasser:	Ersahin, Mehmet, Toklu, Hale Z., Çetinel, Şule, Yüksel, Meral, Yeğen, Berrak Ç., Şener, Göksel
Format:	Artikel
Sprache:	eng
Schlagworte:	Analysis of Variance Animals antioxidant Antioxidants - pharmacology Antioxidants - therapeutic use Basilar Artery - ultrastructure Biological and medical sciences Brain - drug effects Brain - metabolism Brain - pathology Disease Models, Animal Fundamental and applied biological sciences. Psychology lipid peroxidation Lipid Peroxidation - drug effects Male Medical sciences melatonin Melatonin - pharmacology Melatonin - therapeutic use Microscopy, Electron, Transmission Neurologic Examination Neurology Neuroprotective Agents - pharmacology Neuroprotective Agents - therapeutic use Oxidative Stress - drug effects Rats Rats, Wistar subarachnoid hemorrhage Subarachnoid Hemorrhage - drug therapy Subarachnoid Hemorrhage - pathology Vascular diseases and vascular malformations of the nervous system Vertebrates: endocrinology
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