3,3',5-Triiodo-L-thyronine up-regulation of Na,K-ATPase activity and cell surface expression in alveolar epithelial cells is Src kinase- and phosphoinositide 3-kinase-dependent

We previously reported that thyroid hormone, 3,3',5-triiodo-l-thyronine (T3), increased Na,K-ATPase activity of adult rat alveolar epithelial cells in a transcription-independent manner via increased cell surface expression of the alpha(1) and beta(1) subunits of Na,K-ATPase. Now we sought to i...

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Veröffentlicht in:	The Journal of biological chemistry 2004-11, Vol.279 (46), p.47589-47600
Hauptverfasser:	Lei, Jianxun, Mariash, Cary N, Ingbar, David H
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Cells, Cultured Cyclic AMP-Dependent Protein Kinases - antagonists & inhibitors Cyclic AMP-Dependent Protein Kinases - metabolism Enzyme Activation Epithelial Cells - cytology Epithelial Cells - metabolism Male Phosphatidylinositol 3-Kinases - genetics Phosphatidylinositol 3-Kinases - metabolism Phosphoinositide-3 Kinase Inhibitors Protein Kinase C - antagonists & inhibitors Protein Kinase C - metabolism Protein Kinase Inhibitors - metabolism Protein Subunits - genetics Protein Subunits - metabolism Protein-Serine-Threonine Kinases - metabolism Proto-Oncogene Proteins - metabolism Proto-Oncogene Proteins c-akt Pulmonary Alveoli - cytology Pulmonary Alveoli - metabolism Rats Rats, Sprague-Dawley Signal Transduction - physiology Sodium-Potassium-Exchanging ATPase - metabolism src-Family Kinases - antagonists & inhibitors src-Family Kinases - genetics src-Family Kinases - metabolism Triiodothyronine - metabolism Up-Regulation
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