The Dnmt1 DNA-(cytosine-C5)-methyltransferase Methylates DNA Processively with High Preference for Hemimethylated Target Sites

In the cell, Dnmt1 is the major enzyme in maintenance of the pattern of DNA methylation after DNA replication. Evidence suggests that the protein is located at the replication fork, where it could directly modify nascent DNA immediately after replication. To elucidate the potential mechanism of this...

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Veröffentlicht in:	The Journal of biological chemistry 2004-11, Vol.279 (46), p.48350-48359
Hauptverfasser:	Hermann, Andrea, Goyal, Rachna, Jeltsch, Albert
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Base Sequence DNA (Cytosine-5-)-Methyltransferase 1 DNA (Cytosine-5-)-Methyltransferases - metabolism DNA - chemistry DNA - metabolism DNA Methylation DNA Replication Enzyme Activation Mice Molecular Sequence Data Oligonucleotides - genetics Oligonucleotides - metabolism Sequence Alignment
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