Genetic polymorphisms of L-type calcium channel alpha1C and alpha1D subunit genes are associated with sensitivity to the antihypertensive effects of L-type dihydropyridine calcium-channel blockers

The response of blood pressure (BP) to L-type dihydropyridine calcium-channel blockers (dCCBs) differs among individuals. A pharmacogenomic analysis was undertaken in 161 patients with essential hypertension who were treated with dCCBs to study whether genetic polymorphisms of the calcium channel al...

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Veröffentlicht in:	Circulation journal : official journal of the Japanese Circulation Society 2009-04, Vol.73 (4), p.732-740
Hauptverfasser:	Kamide, Kei, Yang, Jin, Matayoshi, Tetsutaro, Takiuchi, Shin, Horio, Takeshi, Yoshii, Masayoshi, Miwa, Yoshikazu, Yasuda, Hisayo, Yoshihara, Fumiki, Nakamura, Satoko, Nakahama, Hajime, Miyata, Toshiyuki, Kawano, Yuhei
Format:	Artikel
Sprache:	eng
Schlagworte:	Aged Alleles Calcium Channel Blockers - administration & dosage Calcium Channels, L-Type - genetics Dihydropyridines - administration & dosage Female Humans Hypertension - drug therapy Hypertension - genetics Hypertension - physiopathology Male Middle Aged Polymorphism, Single Nucleotide
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