Dietary cycloinulooligosaccharides enhance intestinal immunoglobulin A production in mice
The purpose of this study was to elucidate the effects of dietary supplemented cycloinulooligosaccharides (CF) on the intestinal immune function and humoral immunity in BALB/c mice. The mice were orally administered with a control diet or a diet containing 5% CF for 6 weeks. The fecal IgA level, an...
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| Veröffentlicht in: | Bioscience, biotechnology, and biochemistry biotechnology, and biochemistry, 2009-03, Vol.73 (3), p.677-682 |
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| creator | Ishikawa, T.(Mitsui Norin Co. Ltd., Fujieda, Shizuoka (Japan). Food Research Lab.) Nanjo, F |
| description | The purpose of this study was to elucidate the effects of dietary supplemented cycloinulooligosaccharides (CF) on the intestinal immune function and humoral immunity in BALB/c mice. The mice were orally administered with a control diet or a diet containing 5% CF for 6 weeks. The fecal IgA level, an indicator of the intestinal immune response, was increased dramatically by 5% CF feeding, and casein-specific IgA in the feces was also significantly increased. The amounts of short-chain fatty acids (SCFA) in the cecal contents and feces were significantly higher in the 5% CF group than in the control group. On the other hand, CF administration had only a slight affect on the plasma IgA and IgG levels and no effect on the plasma IgE and IgM levels. These results indicate that dietary CF up-regulated the intestinal immune response, but not the humoral immune response. Furthermore, the dose-dependent effect of CF feeding on IgA and SCFA production was examined. Significant increases in the fecal IgA and SCFA levels were observed in the mice fed with 5% CF, but not in the 1% and 2.5% CF-fed groups, indicating that the amount of CF administered was an important factor for up-regulation of the intestinal immune function. |
| doi_str_mv | 10.1271/bbb.80733 |
| format | Article |
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Ltd., Fujieda, Shizuoka (Japan). Food Research Lab.) ; Nanjo, F</creator><creatorcontrib>Ishikawa, T.(Mitsui Norin Co. Ltd., Fujieda, Shizuoka (Japan). Food Research Lab.) ; Nanjo, F</creatorcontrib><description>The purpose of this study was to elucidate the effects of dietary supplemented cycloinulooligosaccharides (CF) on the intestinal immune function and humoral immunity in BALB/c mice. The mice were orally administered with a control diet or a diet containing 5% CF for 6 weeks. The fecal IgA level, an indicator of the intestinal immune response, was increased dramatically by 5% CF feeding, and casein-specific IgA in the feces was also significantly increased. The amounts of short-chain fatty acids (SCFA) in the cecal contents and feces were significantly higher in the 5% CF group than in the control group. On the other hand, CF administration had only a slight affect on the plasma IgA and IgG levels and no effect on the plasma IgE and IgM levels. These results indicate that dietary CF up-regulated the intestinal immune response, but not the humoral immune response. Furthermore, the dose-dependent effect of CF feeding on IgA and SCFA production was examined. Significant increases in the fecal IgA and SCFA levels were observed in the mice fed with 5% CF, but not in the 1% and 2.5% CF-fed groups, indicating that the amount of CF administered was an important factor for up-regulation of the intestinal immune function.</description><identifier>ISSN: 0916-8451</identifier><identifier>EISSN: 1347-6947</identifier><identifier>DOI: 10.1271/bbb.80733</identifier><identifier>PMID: 19270367</identifier><language>eng</language><publisher>Tokyo: Japan Society for Bioscience, Biotechnology, and Agrochemistry</publisher><subject>ADMINISTRACION ORAL ; ADMINISTRATION ORALE ; Animals ; Antibodies - blood ; Biological and medical sciences ; BLOOD PLASMA ; Body Weight - drug effects ; cycloinulooligosaccharide ; Dietary Carbohydrates - pharmacology ; DOSAGE ; DOSE ; Dose-Response Relationship, Drug ; DOSIFICACION ; Eating - drug effects ; FAECES ; Fatty Acids, Volatile - biosynthesis ; Fatty Acids, Volatile - metabolism ; FECES ; Female ; Fundamental and applied biological sciences. Psychology ; gastrointestinal immune function ; HECES ; IgA ; Immunoglobulin A - biosynthesis ; Immunoglobulin A - blood ; Immunoglobulin A - metabolism ; IMMUNOGLOBULINE ; IMMUNOGLOBULINS ; INMUNOGLOBULINA ; INTESTIN ; INTESTINES ; Intestines - drug effects ; Intestines - immunology ; Intestines - metabolism ; INTESTINOS ; INULIN ; INULINA ; INULINE ; Mice ; Mice, Inbred BALB C ; OLIGOSACARIDOS ; OLIGOSACCHARIDE ; OLIGOSACCHARIDES ; Oligosaccharides - pharmacology ; ORAL ADMINISTRATION ; Organ Size - drug effects ; PLASMA SANGUIN ; PLASMA SANGUINEO ; prebiotics ; RAT ; RATA ; RATS ; short-chain fatty acids (SCFA)</subject><ispartof>Bioscience, biotechnology, and biochemistry, 2009-03, Vol.73 (3), p.677-682</ispartof><rights>2009 by Japan Society for Bioscience, Biotechnology, and Agrochemistry 2009</rights><rights>2009 INIST-CNRS</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c593t-287bd2c7d4633aabd2b3ffad1a5b0fd0cb5353482d50d37c65917cde410a9b3e3</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=21415700$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/19270367$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Ishikawa, T.(Mitsui Norin Co. Ltd., Fujieda, Shizuoka (Japan). Food Research Lab.)</creatorcontrib><creatorcontrib>Nanjo, F</creatorcontrib><title>Dietary cycloinulooligosaccharides enhance intestinal immunoglobulin A production in mice</title><title>Bioscience, biotechnology, and biochemistry</title><addtitle>Biosci Biotechnol Biochem</addtitle><description>The purpose of this study was to elucidate the effects of dietary supplemented cycloinulooligosaccharides (CF) on the intestinal immune function and humoral immunity in BALB/c mice. The mice were orally administered with a control diet or a diet containing 5% CF for 6 weeks. The fecal IgA level, an indicator of the intestinal immune response, was increased dramatically by 5% CF feeding, and casein-specific IgA in the feces was also significantly increased. The amounts of short-chain fatty acids (SCFA) in the cecal contents and feces were significantly higher in the 5% CF group than in the control group. On the other hand, CF administration had only a slight affect on the plasma IgA and IgG levels and no effect on the plasma IgE and IgM levels. These results indicate that dietary CF up-regulated the intestinal immune response, but not the humoral immune response. Furthermore, the dose-dependent effect of CF feeding on IgA and SCFA production was examined. Significant increases in the fecal IgA and SCFA levels were observed in the mice fed with 5% CF, but not in the 1% and 2.5% CF-fed groups, indicating that the amount of CF administered was an important factor for up-regulation of the intestinal immune function.</description><subject>ADMINISTRACION ORAL</subject><subject>ADMINISTRATION ORALE</subject><subject>Animals</subject><subject>Antibodies - blood</subject><subject>Biological and medical sciences</subject><subject>BLOOD PLASMA</subject><subject>Body Weight - drug effects</subject><subject>cycloinulooligosaccharide</subject><subject>Dietary Carbohydrates - pharmacology</subject><subject>DOSAGE</subject><subject>DOSE</subject><subject>Dose-Response Relationship, Drug</subject><subject>DOSIFICACION</subject><subject>Eating - drug effects</subject><subject>FAECES</subject><subject>Fatty Acids, Volatile - biosynthesis</subject><subject>Fatty Acids, Volatile - metabolism</subject><subject>FECES</subject><subject>Female</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>gastrointestinal immune function</subject><subject>HECES</subject><subject>IgA</subject><subject>Immunoglobulin A - biosynthesis</subject><subject>Immunoglobulin A - blood</subject><subject>Immunoglobulin A - metabolism</subject><subject>IMMUNOGLOBULINE</subject><subject>IMMUNOGLOBULINS</subject><subject>INMUNOGLOBULINA</subject><subject>INTESTIN</subject><subject>INTESTINES</subject><subject>Intestines - drug effects</subject><subject>Intestines - immunology</subject><subject>Intestines - metabolism</subject><subject>INTESTINOS</subject><subject>INULIN</subject><subject>INULINA</subject><subject>INULINE</subject><subject>Mice</subject><subject>Mice, Inbred BALB C</subject><subject>OLIGOSACARIDOS</subject><subject>OLIGOSACCHARIDE</subject><subject>OLIGOSACCHARIDES</subject><subject>Oligosaccharides - pharmacology</subject><subject>ORAL ADMINISTRATION</subject><subject>Organ Size - drug effects</subject><subject>PLASMA SANGUIN</subject><subject>PLASMA SANGUINEO</subject><subject>prebiotics</subject><subject>RAT</subject><subject>RATA</subject><subject>RATS</subject><subject>short-chain fatty acids (SCFA)</subject><issn>0916-8451</issn><issn>1347-6947</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2009</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqF0UtLHTEUB_AglXrVLvoBWmaj0MVonpOZpdinCLpoF12Fk8dcUzKJTWYo99sbvbd2U3AREsLvnBz-QegtwWeESnKutT7rsWRsD60I47LtBi5foRUeSNf2XJADdFjKL4zrhSCv0QEZqMSskyv086N3M-RNYzYmJB-XkFLw61TAmDvI3rrSuHgH0bjGx9mV2UcIjZ-mJaZ1SHoJPjYXzX1OdjGzT7GyZvLGHaP9EUJxb3b7Efrx-dP3y6_t9c2Xb5cX160RA5tb2kttqZGWd4wB1LNm4wiWgNB4tNhowQTjPbUCWyZNJwYijXWcYBg0c-wInW771hF-L3VANfliXAgQXVqK6iQWddEXIcVcYCpIhR-20ORUSnajus9-qiEpgtVj4KoGrp4Cr_b9rumiJ2f_yV3CFZzsABQDYcw1Sl-eHSWcCIlxdXzrfBxTnuBPysGqGTYh5b9F7H_vv9uWjZAUrHNVV7e0fnRtSXrKHgBfq6TB</recordid><startdate>20090323</startdate><enddate>20090323</enddate><creator>Ishikawa, T.(Mitsui Norin Co. 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Food Research Lab.) ; Nanjo, F</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c593t-287bd2c7d4633aabd2b3ffad1a5b0fd0cb5353482d50d37c65917cde410a9b3e3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2009</creationdate><topic>ADMINISTRACION ORAL</topic><topic>ADMINISTRATION ORALE</topic><topic>Animals</topic><topic>Antibodies - blood</topic><topic>Biological and medical sciences</topic><topic>BLOOD PLASMA</topic><topic>Body Weight - drug effects</topic><topic>cycloinulooligosaccharide</topic><topic>Dietary Carbohydrates - pharmacology</topic><topic>DOSAGE</topic><topic>DOSE</topic><topic>Dose-Response Relationship, Drug</topic><topic>DOSIFICACION</topic><topic>Eating - drug effects</topic><topic>FAECES</topic><topic>Fatty Acids, Volatile - biosynthesis</topic><topic>Fatty Acids, Volatile - metabolism</topic><topic>FECES</topic><topic>Female</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>gastrointestinal immune function</topic><topic>HECES</topic><topic>IgA</topic><topic>Immunoglobulin A - biosynthesis</topic><topic>Immunoglobulin A - blood</topic><topic>Immunoglobulin A - metabolism</topic><topic>IMMUNOGLOBULINE</topic><topic>IMMUNOGLOBULINS</topic><topic>INMUNOGLOBULINA</topic><topic>INTESTIN</topic><topic>INTESTINES</topic><topic>Intestines - drug effects</topic><topic>Intestines - immunology</topic><topic>Intestines - metabolism</topic><topic>INTESTINOS</topic><topic>INULIN</topic><topic>INULINA</topic><topic>INULINE</topic><topic>Mice</topic><topic>Mice, Inbred BALB C</topic><topic>OLIGOSACARIDOS</topic><topic>OLIGOSACCHARIDE</topic><topic>OLIGOSACCHARIDES</topic><topic>Oligosaccharides - pharmacology</topic><topic>ORAL ADMINISTRATION</topic><topic>Organ Size - drug effects</topic><topic>PLASMA SANGUIN</topic><topic>PLASMA SANGUINEO</topic><topic>prebiotics</topic><topic>RAT</topic><topic>RATA</topic><topic>RATS</topic><topic>short-chain fatty acids (SCFA)</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Ishikawa, T.(Mitsui Norin Co. Ltd., Fujieda, Shizuoka (Japan). Food Research Lab.)</creatorcontrib><creatorcontrib>Nanjo, F</creatorcontrib><collection>AGRIS</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Biotechnology Research Abstracts</collection><collection>Immunology Abstracts</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Bioscience, biotechnology, and biochemistry</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Ishikawa, T.(Mitsui Norin Co. Ltd., Fujieda, Shizuoka (Japan). Food Research Lab.)</au><au>Nanjo, F</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Dietary cycloinulooligosaccharides enhance intestinal immunoglobulin A production in mice</atitle><jtitle>Bioscience, biotechnology, and biochemistry</jtitle><addtitle>Biosci Biotechnol Biochem</addtitle><date>2009-03-23</date><risdate>2009</risdate><volume>73</volume><issue>3</issue><spage>677</spage><epage>682</epage><pages>677-682</pages><issn>0916-8451</issn><eissn>1347-6947</eissn><abstract>The purpose of this study was to elucidate the effects of dietary supplemented cycloinulooligosaccharides (CF) on the intestinal immune function and humoral immunity in BALB/c mice. The mice were orally administered with a control diet or a diet containing 5% CF for 6 weeks. The fecal IgA level, an indicator of the intestinal immune response, was increased dramatically by 5% CF feeding, and casein-specific IgA in the feces was also significantly increased. The amounts of short-chain fatty acids (SCFA) in the cecal contents and feces were significantly higher in the 5% CF group than in the control group. On the other hand, CF administration had only a slight affect on the plasma IgA and IgG levels and no effect on the plasma IgE and IgM levels. These results indicate that dietary CF up-regulated the intestinal immune response, but not the humoral immune response. Furthermore, the dose-dependent effect of CF feeding on IgA and SCFA production was examined. Significant increases in the fecal IgA and SCFA levels were observed in the mice fed with 5% CF, but not in the 1% and 2.5% CF-fed groups, indicating that the amount of CF administered was an important factor for up-regulation of the intestinal immune function.</abstract><cop>Tokyo</cop><pub>Japan Society for Bioscience, Biotechnology, and Agrochemistry</pub><pmid>19270367</pmid><doi>10.1271/bbb.80733</doi><tpages>6</tpages><oa>free_for_read</oa></addata></record> |
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| source | J-STAGE Free; MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; Oxford University Press Journals All Titles (1996-Current); Freely Accessible Japanese Titles; Free Full-Text Journals in Chemistry |
| subjects | ADMINISTRACION ORAL ADMINISTRATION ORALE Animals Antibodies - blood Biological and medical sciences BLOOD PLASMA Body Weight - drug effects cycloinulooligosaccharide Dietary Carbohydrates - pharmacology DOSAGE DOSE Dose-Response Relationship, Drug DOSIFICACION Eating - drug effects FAECES Fatty Acids, Volatile - biosynthesis Fatty Acids, Volatile - metabolism FECES Female Fundamental and applied biological sciences. Psychology gastrointestinal immune function HECES IgA Immunoglobulin A - biosynthesis Immunoglobulin A - blood Immunoglobulin A - metabolism IMMUNOGLOBULINE IMMUNOGLOBULINS INMUNOGLOBULINA INTESTIN INTESTINES Intestines - drug effects Intestines - immunology Intestines - metabolism INTESTINOS INULIN INULINA INULINE Mice Mice, Inbred BALB C OLIGOSACARIDOS OLIGOSACCHARIDE OLIGOSACCHARIDES Oligosaccharides - pharmacology ORAL ADMINISTRATION Organ Size - drug effects PLASMA SANGUIN PLASMA SANGUINEO prebiotics RAT RATA RATS short-chain fatty acids (SCFA) |
| title | Dietary cycloinulooligosaccharides enhance intestinal immunoglobulin A production in mice |
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