Conditional Inactivation of Glucocorticoid Receptor Gene in Dopamine-β-Hydroxylase Cells Impairs Chromaffin Cell Survival

Glucocorticoid hormones (GCs) have been thought to determine the fate of chromaffin cells from sympathoadrenal progenitor cells. The analysis of mice carrying a germ line deletion of the glucocorticoid receptor (GR) gene has challenged these previous results because the embryonic development of adre...

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Veröffentlicht in:	Endocrinology (Philadelphia) 2009-04, Vol.150 (4), p.1775-1781
Hauptverfasser:	Parlato, Rosanna, Otto, Christiane, Tuckermann, Jan, Stotz, Stefanie, Kaden, Sylvia, Gröne, Hermann-Josef, Unsicker, Klaus, Schütz, Günther
Format:	Artikel
Sprache:	eng
Schlagworte:	Adrenal glands Adrenal Glands - cytology Adrenal Glands - metabolism Adrenal medulla Adrenal Medulla - metabolism Adrenal Medulla - pathology Animals Apoptosis Biological and medical sciences Cell death Cell differentiation Cell survival Cell Survival - genetics Cells (biology) Cells, Cultured Chromaffin cells Chromaffin Cells - cytology Chromaffin Cells - metabolism Clonal deletion Deactivation Differentiation (biology) Dopamine Dopamine beta-Hydroxylase - metabolism Dopamine β-monooxygenase Embryogenesis Embryonic growth stage Epinephrine Fundamental and applied biological sciences. Psychology Gene deletion Glucocorticoid receptors Glucocorticoids Hormones Immunohistochemistry In Situ Nick-End Labeling Inactivation Mice Noradrenaline Norepinephrine Phenylethanolamine N-Methyltransferase - metabolism Progenitor cells Receptors Receptors, Glucocorticoid - genetics Receptors, Glucocorticoid - physiology Survival Sympathetic nervous system Synthesis Vertebrates: endocrinology
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