Early maternal deprivation induces alterations in brain-derived neurotrophic factor expression in the developing rat hippocampus
The effects of maternal deprivation (MD) during early postnatal life on the brain-derived neurotrophic factor (BDNF) level were investigated in the present study. Wistar rats were assigned to either maternal deprivation or mother-reared control (MRC) groups. MD manipulation was achieved by separatin...
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| Veröffentlicht in: | Neuroscience letters 2004-11, Vol.372 (1), p.68-73 |
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| creator | Kuma, Hiromi Miki, Takanori Matsumoto, Yoshiki Gu, He Li, Hong-Peng Kusaka, Takashi Satriotomo, Irawan Okamoto, Hanayo Yokoyama, Toshifumi S. Bedi, Kuldip Onishi, Shoju Suwaki, Hiroshi Takeuchi, Yoshiki |
| description | The effects of maternal deprivation (MD) during early postnatal life on the brain-derived neurotrophic factor (BDNF) level were investigated in the present study. Wistar rats were assigned to either maternal deprivation or mother-reared control (MRC) groups. MD manipulation was achieved by separating rat pups from their mothers for 3
h a day during postnatal days (PND) 10–15. At 16, 20, 30, and 60 days of age, the level of BDNF mRNA in the hippocampal formation of each group was determined using real-time PCR analysis. Early postnatal maternal deprivation of rat pups resulted in a significant increase in body weight at 60 days of age. The expression of BDNF mRNA in the hippocampus was significantly decreased at 16 days of age, and increased at 30 and 60 days of age. These data indicate that even a brief period of maternal deprivation during early postnatal life can affect hippocampal BDNF expression. |
| doi_str_mv | 10.1016/j.neulet.2004.09.012 |
| format | Article |
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h a day during postnatal days (PND) 10–15. At 16, 20, 30, and 60 days of age, the level of BDNF mRNA in the hippocampal formation of each group was determined using real-time PCR analysis. Early postnatal maternal deprivation of rat pups resulted in a significant increase in body weight at 60 days of age. The expression of BDNF mRNA in the hippocampus was significantly decreased at 16 days of age, and increased at 30 and 60 days of age. These data indicate that even a brief period of maternal deprivation during early postnatal life can affect hippocampal BDNF expression.</description><identifier>ISSN: 0304-3940</identifier><identifier>EISSN: 1872-7972</identifier><identifier>DOI: 10.1016/j.neulet.2004.09.012</identifier><identifier>PMID: 15531090</identifier><identifier>CODEN: NELED5</identifier><language>eng</language><publisher>Shannon: Elsevier Ireland Ltd</publisher><subject>Animals ; Animals, Newborn ; BDNF mRNA ; Biological and medical sciences ; Brain-Derived Neurotrophic Factor - biosynthesis ; Brain-Derived Neurotrophic Factor - genetics ; Development ; Female ; Fundamental and applied biological sciences. Psychology ; Gene Expression Regulation, Developmental - physiology ; Hippocampus ; Hippocampus - growth & development ; Hippocampus - metabolism ; Maternal Deprivation ; Maternal separation ; Pregnancy ; Rats ; Rats, Wistar ; Real-time PCR ; Vertebrates: nervous system and sense organs</subject><ispartof>Neuroscience letters, 2004-11, Vol.372 (1), p.68-73</ispartof><rights>2004 Elsevier Ireland Ltd</rights><rights>2005 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c454t-9ea1bfc0900338054b70f37d7f28b24fc3e061f37721f9f692da5414e664c8973</citedby><cites>FETCH-LOGICAL-c454t-9ea1bfc0900338054b70f37d7f28b24fc3e061f37721f9f692da5414e664c8973</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0304394004011358$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65306</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=16258897$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/15531090$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Kuma, Hiromi</creatorcontrib><creatorcontrib>Miki, Takanori</creatorcontrib><creatorcontrib>Matsumoto, Yoshiki</creatorcontrib><creatorcontrib>Gu, He</creatorcontrib><creatorcontrib>Li, Hong-Peng</creatorcontrib><creatorcontrib>Kusaka, Takashi</creatorcontrib><creatorcontrib>Satriotomo, Irawan</creatorcontrib><creatorcontrib>Okamoto, Hanayo</creatorcontrib><creatorcontrib>Yokoyama, Toshifumi</creatorcontrib><creatorcontrib>S. Bedi, Kuldip</creatorcontrib><creatorcontrib>Onishi, Shoju</creatorcontrib><creatorcontrib>Suwaki, Hiroshi</creatorcontrib><creatorcontrib>Takeuchi, Yoshiki</creatorcontrib><title>Early maternal deprivation induces alterations in brain-derived neurotrophic factor expression in the developing rat hippocampus</title><title>Neuroscience letters</title><addtitle>Neurosci Lett</addtitle><description>The effects of maternal deprivation (MD) during early postnatal life on the brain-derived neurotrophic factor (BDNF) level were investigated in the present study. Wistar rats were assigned to either maternal deprivation or mother-reared control (MRC) groups. MD manipulation was achieved by separating rat pups from their mothers for 3
h a day during postnatal days (PND) 10–15. At 16, 20, 30, and 60 days of age, the level of BDNF mRNA in the hippocampal formation of each group was determined using real-time PCR analysis. Early postnatal maternal deprivation of rat pups resulted in a significant increase in body weight at 60 days of age. The expression of BDNF mRNA in the hippocampus was significantly decreased at 16 days of age, and increased at 30 and 60 days of age. These data indicate that even a brief period of maternal deprivation during early postnatal life can affect hippocampal BDNF expression.</description><subject>Animals</subject><subject>Animals, Newborn</subject><subject>BDNF mRNA</subject><subject>Biological and medical sciences</subject><subject>Brain-Derived Neurotrophic Factor - biosynthesis</subject><subject>Brain-Derived Neurotrophic Factor - genetics</subject><subject>Development</subject><subject>Female</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Gene Expression Regulation, Developmental - physiology</subject><subject>Hippocampus</subject><subject>Hippocampus - growth & development</subject><subject>Hippocampus - metabolism</subject><subject>Maternal Deprivation</subject><subject>Maternal separation</subject><subject>Pregnancy</subject><subject>Rats</subject><subject>Rats, Wistar</subject><subject>Real-time PCR</subject><subject>Vertebrates: nervous system and sense organs</subject><issn>0304-3940</issn><issn>1872-7972</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2004</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kE2L1TAUhoMoznX0H4hko7vWkzRt2o0gw_gBA250HdLkxJtL2tSkvTg7f7oZe2F2rgJvnvPy8hDymkHNgHXvT_WMW8C15gCihqEGxp-QA-slr-Qg-VNygAZE1QwCrsiLnE8A0LJWPCdXrG0bBgMcyJ9bncI9nfSKadaBWlySP-vVx5n62W4GM9WhfP6LcsnomLSfK4uFQ0vLiBTXFJejN9Rps8ZE8feSMOe9g65HLLVnDHHx809amujRL0s0elq2_JI8czpkfHV5r8mPT7ffb75Ud98-f735eFcZ0Yq1GlCz0ZmyGZqmh1aMElwjrXS8H7lwpkHoWEkkZ25w3cCtbgUT2HXC9INsrsm7vXdJ8deGeVWTzwZD0DPGLatOQttxDgUUO2hSzDmhU8XIpNO9YqAezKuT2s2rB_MKBlXMl7M3l_5tnNA-Hl1UF-DtBdDZ6OCSno3Pj1zH234f-mHnsNg4e0wqG4-zQesTmlXZ6P-_5C8sHaZ7</recordid><startdate>20041130</startdate><enddate>20041130</enddate><creator>Kuma, Hiromi</creator><creator>Miki, Takanori</creator><creator>Matsumoto, Yoshiki</creator><creator>Gu, He</creator><creator>Li, Hong-Peng</creator><creator>Kusaka, Takashi</creator><creator>Satriotomo, Irawan</creator><creator>Okamoto, Hanayo</creator><creator>Yokoyama, Toshifumi</creator><creator>S. Bedi, Kuldip</creator><creator>Onishi, Shoju</creator><creator>Suwaki, Hiroshi</creator><creator>Takeuchi, Yoshiki</creator><general>Elsevier Ireland Ltd</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20041130</creationdate><title>Early maternal deprivation induces alterations in brain-derived neurotrophic factor expression in the developing rat hippocampus</title><author>Kuma, Hiromi ; Miki, Takanori ; Matsumoto, Yoshiki ; Gu, He ; Li, Hong-Peng ; Kusaka, Takashi ; Satriotomo, Irawan ; Okamoto, Hanayo ; Yokoyama, Toshifumi ; S. 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Psychology</topic><topic>Gene Expression Regulation, Developmental - physiology</topic><topic>Hippocampus</topic><topic>Hippocampus - growth & development</topic><topic>Hippocampus - metabolism</topic><topic>Maternal Deprivation</topic><topic>Maternal separation</topic><topic>Pregnancy</topic><topic>Rats</topic><topic>Rats, Wistar</topic><topic>Real-time PCR</topic><topic>Vertebrates: nervous system and sense organs</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Kuma, Hiromi</creatorcontrib><creatorcontrib>Miki, Takanori</creatorcontrib><creatorcontrib>Matsumoto, Yoshiki</creatorcontrib><creatorcontrib>Gu, He</creatorcontrib><creatorcontrib>Li, Hong-Peng</creatorcontrib><creatorcontrib>Kusaka, Takashi</creatorcontrib><creatorcontrib>Satriotomo, Irawan</creatorcontrib><creatorcontrib>Okamoto, Hanayo</creatorcontrib><creatorcontrib>Yokoyama, Toshifumi</creatorcontrib><creatorcontrib>S. 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h a day during postnatal days (PND) 10–15. At 16, 20, 30, and 60 days of age, the level of BDNF mRNA in the hippocampal formation of each group was determined using real-time PCR analysis. Early postnatal maternal deprivation of rat pups resulted in a significant increase in body weight at 60 days of age. The expression of BDNF mRNA in the hippocampus was significantly decreased at 16 days of age, and increased at 30 and 60 days of age. These data indicate that even a brief period of maternal deprivation during early postnatal life can affect hippocampal BDNF expression.</abstract><cop>Shannon</cop><pub>Elsevier Ireland Ltd</pub><pmid>15531090</pmid><doi>10.1016/j.neulet.2004.09.012</doi><tpages>6</tpages></addata></record> |
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| ispartof | Neuroscience letters, 2004-11, Vol.372 (1), p.68-73 |
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| subjects | Animals Animals, Newborn BDNF mRNA Biological and medical sciences Brain-Derived Neurotrophic Factor - biosynthesis Brain-Derived Neurotrophic Factor - genetics Development Female Fundamental and applied biological sciences. Psychology Gene Expression Regulation, Developmental - physiology Hippocampus Hippocampus - growth & development Hippocampus - metabolism Maternal Deprivation Maternal separation Pregnancy Rats Rats, Wistar Real-time PCR Vertebrates: nervous system and sense organs |
| title | Early maternal deprivation induces alterations in brain-derived neurotrophic factor expression in the developing rat hippocampus |
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