Chemoenzymatic and microbial dynamic kinetic resolutions
This review tracks a decade of dynamic kinetic resolution developments with a biocatalytic inclination using enzymatic/microbial means for the resolution part followed by the racemization reactions either by means of enzymatic or chemocatalyst. These fast developments are due to the ability of the b...
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| Veröffentlicht in: | Chirality (New York, N.Y.) N.Y.), 2009-04, Vol.21 (4), p.449-467 |
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| container_title | Chirality (New York, N.Y.) |
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| creator | Kamaruddin, Azlina Harun Uzir, Mohamad Hekarl Aboul-Enein, Hassan Y. Halim, Hairul Nazirah Abdul |
| description | This review tracks a decade of dynamic kinetic resolution developments with a biocatalytic inclination using enzymatic/microbial means for the resolution part followed by the racemization reactions either by means of enzymatic or chemocatalyst. These fast developments are due to the ability of the biocatalysts to significantly reduce the number of synthetic steps which are common for conventional synthesis. Future developments in novel reactions and products of dynamic kinetic resolutions should consider factors that are needed to be extracted at the early synthetic stage to avoid inhibition at scale‐up stage have been highlighted. Chirality, 2009. © 2008 Wiley‐Liss, Inc. |
| doi_str_mv | 10.1002/chir.20619 |
| format | Article |
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| ispartof | Chirality (New York, N.Y.), 2009-04, Vol.21 (4), p.449-467 |
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| language | eng |
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| source | MEDLINE; Wiley Online Library All Journals |
| subjects | Alcohols - chemistry biocatalysts Carboxylic Acids - chemistry Catalysis Chemistry, Organic - methods chemocatalysts chiral resoluion dynamic kinetic resolution Enzymes - chemistry Esterification Esters - chemistry Fenoprofen - chemistry Fungal Proteins - chemistry Hydrolysis Ibuprofen - chemistry Kinetics Molecular Structure Naproxen - chemistry Stereoisomerism Suprofen - chemistry |
| title | Chemoenzymatic and microbial dynamic kinetic resolutions |
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